Massachusetts General Hospital

The Gomez-Isla lab focuses on the development and characterization of transgenic mouse models of Alzheimer's disease and on testing novel therapeutic strategies. Research is also conducted with human brain tissue from individuals who suffered Alzheimer's disease while alive.

Dr. Gomez-Isla’s clinical research focuses on cognitively intact individuals across the age spectrum in order to search for molecular mechanisms responsible for individual vulnerability or resilience to this type of dementia.

Principal Investigator

Teresa Gomez-Isla, MD

• Associate Professor,
  Harvard Medical School
• Neurologist,
  Massachusetts General Hospital

 Research Lab Members

• Beatriz Perez-Nievas Gomez, PhD
• Leticia Fernandez-Carballo, PhD
• Marta Marquire Sayagues, MD
• Isabel Barroeta, MD
• Elena Galea, PhD

Updated 7/11/2012

Genetic cross-interaction between APOE and PRNP 

In this work, we investigated for the first time, APOE and PRNP genotypes simultaneously in 474 AD and 175 sporadic CJD (sCJD) patients compared to a common control population of 335 subjects. Differences in genotype distribution between patients and control subjects were studied by logistic regression analysis using age and gender as covariates.

Updated 7/11/2012

Read about and apply for residency, fellowship and observership programs at http://www.massgeneral.org/neurology/education/.

Apply for temporary positions (summer interns) through the Bulfinch Temporary Service Web site at http://www.massgeneral.org/careers/temporary.aspx. Search for all opportunities using ID# 2200484.

All applicants should register with the Mass General Careers Web site at http://www.massgeneral.org/careers/viewall.aspx. Request a list of current open positions at mghmind-jobs@partners.org.

1. Rapidly Progressive Dementia: Experience in a Tertiary Care Medical Center. Sala I, Marquié M, Sánchez-Saudinós MB, Sánchez-Valle R, Alcolea D, Gómez-Ansón B, Gómez-Isla T, Blesa R, Lleó A. Alzheimer Dis Assoc Disord. 2011 Oct 13. [Epub ahead of print]
2. Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease. DaRocha-Souto B, Coma M, Pérez-Nievas BG, Scotton TC, Siao M, Sánchez-Ferrer P, Hashimoto T, Fan Z, Hudry E, Barroeta I, Serenó L, Rodríguez M, Sánchez MB, Hyman BT, Gómez-Isla T. Neurobiol Dis. 2012 Jan;45(1):425-37. Epub 2011 Sep 13.
3. Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer's and Creutzfeldt-Jakob diseases. Calero O, Bullido MJ, Clarimón J, Frank-García A, Martínez-Martín P, Lleó A, Rey MJ, Rábano A, Blesa R, Gómez-Isla T, Valdivieso F, de Pedro-Cuesta J, Ferrer I, Calero M. PLoS One. 2011;6(7):e22090. Epub 2011 Jul 20.
4. Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease. Serrano-Pozo A, Mielke ML, Gómez-Isla T, Betensky RA, Growdon JH, Frosch MP, Hyman BT. Am J Pathol. 2011 Sep;179(3):1373-84. Epub 2011 Jul 21.
5. Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice. DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T. J Neuropathol Exp Neurol. 2011 May;70(5):360-76.

Updated 7/11/2012

MassGeneral Institute for Neurodegenerative Disease

Phone: 617-726-1278
Fax: 617-724-1480
Email: mghmind@partners.org

Public Transportation Access: yes
Disabled Access: yes

How to Apply for Positions

How to apply for jobs: Send an e-mail to mghmind-jobs@partners.org to receive an automated e-mail with full instructions for all types of positions.

Fundraising Contact

Contact Shawn Fitzgibbons in the Mass General Development office at 617-643-0447 or sfitzgibbons@partners.org.

Administration

Anne B. Young, MD, PhD
Director, Massgeneral Institute for Neurodegenerative Disease 
Professor of Neurology, Harvard Medical School

Directions to MIND Research labs (PDF)

Clinical Appointments, Consultations & Clinical Trials

ALS (Amyotrophic Lateral Sclerosis) Multidisciplinary Clinic
Phone: 617-724-3914

Dystonia Clinic
Phone:  617-643-6997

Frontotemporal Disorders Unit
Phone: 617-726-1728

Huntington's Disease Clinic
Phone: 617-724-9234

Memory Disorders Unit
Phone: 617-726-1728
Alzheimers, Dementia with Lewy Bodys, Frontotemporal dementia, Pick's Disease

Movement Disorders Unit
Phone: 617-726-5532
Dystonia, Huntingtons, Parkinsons

Parkinson Disease and Movement Disorders Clinic
Phone: 617-726-5532