Gomperts Lab

The Gomperts lab investigates Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease


Dr. Gomperts' basic science interests focus on understanding how dopamine cells and cells of the hippocampus communicate with one another and with their target regions to guide behaviors.

Dr. Gomperts' clinical interests are cognitive impairment and dementias, such as dementia with Lewy bodies and Alzheimer's disease, as well as movement disorders such as Parkinson's disease. His clinical research interests include the development of blood and imaging biomakers for cognitive impairment in dementia with Lewy bodies and Parkinson's disease.

Group Members


Principal Investigator

Stephen N. Gomperts, MD, PhD

  • Instructor in Neurology 
    Harvard Medical School
  • Assistant in Neurology,
    Massachusetts General Hospital



Lab Members

  • Kevin Neville, PhD
  • Daniel Graziano, Tech II

Research Projects

Could brain amyloid deposition be a factor in early onset dementia in patients with dementia with Lewy bodies (DLB)?

In this clinical study we sought to confirm the hypothesis that brain amyloid deposition, an early feature of Dementia with Lewy Bodies, may account, in part, for its early dementia.We also to determine whether amyloid accumulation contributes to cognitive impairment and dementia in the broad range of parkinsonian diseases. Many patients with Parkinson's disease develop PD with dementia (PDD), a syndrome that overlaps clinically and pathologically with dementia with Lewy bodies; PDD and DLB differ chiefly in the relative timing of dementia and parkinsonism.

Research Positions

Request a list of currently open positions at mghneurologyjobs@partners.org.

Read about and apply for residency, fellowship and observership programs at http://www.massgeneral.org/neurology/education/.

All applicants should register with the Mass General Careers Web site at http://www.massgeneral.org/careers/viewall.aspx.


View all publications on Pubmed

  1. Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia.
    Gomperts SN, Locascio JJ, Rentz D, Santarlasci A, Marquie M, Johnson KA, Growdon JH.
    Neurology. 2013 Jan 1;80(1):85-91. doi: 10.1212/WNL.0b013e31827b1a07. Epub 2012 Dec 12.
    PMID: 23243071 [PubMed - indexed for MEDLINE]
  2. Brain amyloid and cognition in Lewy body diseases.
    Gomperts SN, Locascio JJ, Marquie M, Santarlasci AL, Rentz DM, Maye J, Johnson KA, Growdon JH.
    Mov Disord. 2012 Jul;27(8):965-73. doi: 10.1002/mds.25048. Epub 2012 Jun 12.
    PMID: 22693110 [PubMed - indexed for MEDLINE] Free PMC Article
  3. Micro-drive array for chronic in vivo recording: tetrode assembly.
    Nguyen DP, Layton SP, Hale G, Gomperts SN, Davidson TJ, Kloosterman F, Wilson MA.
    J Vis Exp. 2009 Apr 22;(26). doi:pii: 1098. 10.3791/1098.
    PMID: 19387422 [PubMed - indexed for MEDLINE] Free PMC Article
    Related citations


Contact Us

MassGeneral Institute for Neurodegenerative Disease

Building 114, Charlestown Navy Yard

114 16th Street, Room 2003Mailcode: CNY B114-2-2003 Charlestown, MA 02129
  • Near Public Transit
  • Accessible
  • Phone: 617-726-2000
  • Fax: 617-724-1480

How to Apply for Positions

How to apply for jobs: Send an e-mail to mghneurologyjobs@partners.org to receive an automated e-mail with full instructions for all types of positions.

Fundraising Contact

Contact Krista McCabe in the Mass General Development office at 617-726-1392 or KMCCABE@PARTNERS.ORG.


Anne B. Young, MD, PhD
Director, Massgeneral Institute for Neurodegenerative Disease 
Professor of Neurology, Harvard Medical School

Clinical Appointments, Consultations & Clinical Trials

Please visit the main Neurology Service Contact page for all other contact information.

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