Most of my research efforts in the past few years have been focused on the biology of intestinal epithelia, including drug absorption, inflammation and cancer. My area of study in Dr. McCormick’s Laboratory at the Mucosal Immunology Lab is the functionality of transporter proteins, such as MRP, P-gp and BCRP in intestinal epithelial cells during infection by pathogenic bacteria. We believe that the understanding of how endogenous small molecules, such as the inflammatory mediators derived from the arachidonic acid cascade, are released by the epithelia during infection and inflammation may lead to controlling some of the pathological consequences of these conditions. Furthermore, we look at the potential for direct intervention upon these efflux pathways in the context of the Multi Drug Resistance phenotype of intestinal cancer.
BioSketch:
2004 - present: Postdoctoral Fellow
Mucosal Immunology/Microbiology
Massachusetts General Hospital/Harvard Medical School, Boston, MA
2002 - 2004: Research Associate
Welsh School of Pharmacy, Drug Delivery Group, Cardiff University, Cardiff, UK
Responsibilities: LC-MS/MS identification and analysis of eicosanoids involved in inflammatory events in vitro.
