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Publications by Principal Investigator
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Recent Publications (last 5 years)
Bobby Cherayil, MD
1. Cherayil, B.J., McCormick, B.A., and Bosley, J. Salmonella -dependent regulation of inducible nitric oxide synthase expression in macrophages by the invasins SipB, SipC and SipD, and the effector SopE2. Infect. Immun. 2000; 68: 5567-5574.
2. Cherayil, B.J. and Antos, D. Inducible nitric oxide synthase and Salmonella infection. Microbes Infect. 2001; 3: 771-776.
3. Cherayil, B.J. and Walker, W.A. Ontogeny of the host response to enteric microbial infection. In Microbial Pathogens and the Intestinal Cell, Gail Hecht, Editor, ASM Press, Washington, D.C. 2003.
4. Li, Q. and Cherayil, B.J. The role of Toll-like receptor 4 in macrophage activation and tolerance during Salmonella infection. Infect. Immun. 2003; 71: 4873-4882
5. Cherayil, B.J. How not to get bugged by bugs: mechanisms of cellular tolerance to
microorganisms. Curr.Opin. Gastroenterol. 2003; 19: 572-577.
6. Claud, E.C., Lu, L., Anton, P., Savidge, T., Walker, W.A. and Cherayil, B.J. Developmentally-regulated IkB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. Proc. Natl. Acad. Sci. USA. 2004; 101: 7404-7408.
7. Li, Q., Cherayil, B.J. Toll-like receptor 4 mutation impairs the macrophage TNFa response to peptidoglycan. Biochem. Biophys. Res. Comm. 2004; 325: 91-96.
8. Huang, F.C., Werne, A., Li, Q., Galyov, E.E., Walker, W.A., and Cherayil, B.J. Cooperative interactions between flagellin and SopE2 in the epithelial IL-8 response to Salmonella. Infect. Immun. 2004; 72: 5052-5062.
9. Rhee SJ, Walker WA, and Cherayil BJ. Developmentally-regulated intestinal expression of IFNg and its target genes and the age-specific response to enteric Salmonella infection. J Immunol 2005; 175: 1127-1136.
10. Cariappa A, Mazo IB, Chase C, Shi HN, Liu H, Li Q, Rose H, Leung H, Cherayil BJ, Russell P, von Andrian U and Pillai S. Perisinusoidal B cells in the bone marrow mediate T-independent IgM responses to blood-borne microbes. Immunity 2005; 23: 397-407.
Verena Göbel, MD
1. Rämet M, Pearson A, Manfruelli P, Li X, Koziel H, Göbel V, Chung E, Krieger M, Ezekowitz RA. Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria. Immunity 2001; 15: 1027-1038.
2. Göbel V, Barrett PL, Hall DH, Fleming JT. Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1. Dev Cell 2004; 6: 865-873.
3. Barrett PL, Fleming JT, Göbel V. Targeted gene alteration in Caenorhabditis elegans by gene conversion. Nat Genetics 2004; 36: 1231-1237.
4. Barrett PL, Fleming JT, Göbel V. Targeting and altering genes by geneconversion. A practical guide. (in press) Wormbook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.7.1, http://www.wormbook.org
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Ciarán P. Kelly, MD
1. Warny M, Keates AC, Keates S, Castagliuolo I, Zachs JK, Aboudola S, Qamar A, Pothoulakis C, LaMont JT, Kelly CP. p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis. J Clin Invest 2000;105:1147-1156.
2. Michetti M, Kelly CP, Kraehenbuhl J-P, Bouzourene H, Michetti P. Gastric mucosal alpha(4)beta(7)-integrin-positive CD4 T lymphocytes and immune protection against helicobacter infection in mice. Gastroenterology 2000;119:109-118.
3. Keates AC, Castagliuolo I, Cruickshank WW, Qiu B, Arseneau K, Brazer W, Kelly CP. Interleukin-16 is up-regulated in Crohn’s disease and participates in TNBS colitis in mice. Gastroenterology 2000;119:972-982.
4. Kyne L, Warny M, Qamar A, Kelly CP. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. New Eng J Med 2000;342:390-397.
5. Kyne L, Warny M, Qamar A, Kelly CP. Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea. Lancet 2001;357:189-193.
6. Qamar A, Aboudola S, Warny M, Michetti P, Pothoulakis C, JT LaMont, Kelly CP. Saccharomyces boulardii stimulates an intestinal IgA immune response to Clostridium difficile toxin A in mice. Infection & Immunity 2001;69:2762-2765.
7. Warny M, Aboudola S, Robson SC, Sevigny J, Communi D, Soltoff SP, Kelly CP. P2Y6 Nucleotide Receptor Mediates Monocyte Interleukin-8 Production in Response to UDP or Lipopolysaccharide. J Biol Chem. 2001;276:26051-56.
8. Keates AC, Keates S, Kwon JH, Arseneau KO, Law DJ, Bai L, Merchant JL, Wang TC, Kelly CP. ZBP-89, Sp1 and Fuclear Factor-_B regulate Epithelial Neutrophil-Activating peptide-78 gene expression in Caco-2 human colonic epithelial cells. J Biol Chem 2001;276:43713-43722.
9. Zhao D, Keates AC, Kuhnt-Moore S, Moyer MP, Kelly CP, Pothoulakis C. Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes. J Biol Chem 2001;276:44464-44471.
10. Keates S, Sougioultzis S, Keates AC, Zhao D, Peek RM Jr, Shaw LM, Kelly CP. cag+ H. pylori induce transactivation of the EGF receptor in AGS gastric epithelial cells. J Biol Chem 2001; 276:48127-48134.
11. Tendler DA, Aboudola S, Zacks JK, O’Brien MJ, Kelly CP. Prolapsing mucosal polyps: an underrecognized form of colonic polyp. Am J Gastroenterol 2002;97:370-6.
12. Kyne L, Hamel MB, Polavaram R, Kelly CP. Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clinical Infectious Diseases 2002;34:346-53.
13. Farrell RJ, Menconi MJ, Keates AC, Kelly CP. P-glycoprotein-170 inhibition reduces cortisol and cyclosporin efflux from human intestinal epithelial cells and T-lymphocytes. Aliment Pharmacol Ther 2002;16:1021-1031.
14. Banerjee S, Medina-Fatimi A, Nichols R, Tendler D, Michetti M, Simon J, Kelly CP, Monath TP, Michetti P. Safety and efficacy of low dose Escherichia coli enterotoxin adjuvant for urease based oral immunisation against Helicobacter pylori in healthy volunteers. Gut 2002;51:634-40.
15. Sougioultzis S, Lee CK, Alsahli M, Banerjee S, Cadoz M, Schrader R, Guy B, Bedford P, Monath TP, Kelly CP, Michetti P. Safety and efficacy of E. coli enterotoxin adjuvant for urease-based rectal immunization against Helicobacter pylori. Vaccine 2002;21:194-201.
16. Kyne L, Sougioultzis S, McFarland LV, Kelly CP. Underlying disease severity as a major risk factor for nosocomial Clostridium difficile diarrhea. Infection Control and Hospital Epidemiology 2002;23:653-659.
17. Aboudola S, Kotloff KL, Kyne K, Warny M, Kelly EC, Sougioultzis S, Giannasca PJ, Monath TP, Kelly CP. Clostridium difficile vaccine and IgG antibody response to toxin A. Infect Immun 2003;71:1608-10.
18. Zaman MM, Gelrud A, Junaidi O, Regan MM, Warny M, Shea JC, Kelly C, O'Sullivan BP, Freedman SD. Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered. Clin Diagn Lab Immunol. 2004;11:819-24.
19. Drudy D, Calabi E, Kyne L, Sougioultzis S, Kelly E, Fairweather N, Kelly C. Human antibody response to surface layer proteins in Clostridium difficile infection. FEMS Immunology & Medical Microbiology 2004;41: 237-42.
20. Anton PM, O’Brien M, Kokkotou E, Einsenstein B, Michaelis A, Rothstein D, Paraschos S, Kelly CP, Pothoulakis C. Rifalazil treats and prevents relapse of Clostridium difficile – associated diarrhea in hamsters. Antimicrob Agents Chemother 2004;48: 3975-9.
21. Sougioultzis S, Kyne L, Drudy D, Keates S, Maroo S, Pothoulakis C, Giannasca PJ, Lee CK, Warny M, Monath TP, Kelly CP. Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea. Gastroenterology. 2005;128:764-70.
22. Keates S, Keates AC, Nath S, Peek RM, Jr, Kelly CP. Transactivation of the EGFR by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells. Gut 2005; 54(10):1363-9. Gut online publication as 10.1136/gut.2005.066977.
23. Kwon JH, Keates AC, Anton-Gay P, Botero M, Goldsmith JD, Kelly CP. Topical antisense oligonucleotide therapy against LIX, an enterocyte-expressed CXC chemokine, reduces murine colitis. Am J Physiol Gastrointest Liver Physiol 2005;289(6):G1075-83.
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Beth McCormick, PhD
1. Wood, MW, Jones, MA, Watson, PR, Siber, AM, McCormick, BA, Rosqvist, R, Wallis, TS, and Galyov, EE. The secreted effector protein of Salmonella, SopA, is translocated into eucaryotic cells and influences the induction of enteritis. Cellular Microbiol. 2000; 2:293-304.
2. Cherayil, BJ, McCormick, BA, and Bosley, J. Salmonella-dependent regulation of inducible nitric oxide synthase expression in macrophages by the invasins SipB, SipC, and SipD, and the effector SopE2. Infect. Immun. 2000; 68:5567- 5574.
3. Lee, CA, Silva, M, Siber, AM, Kelly, AJ, Galyov, EE, and McCormick, BA. A secreted Salmonella protein induces a proinflammatory response in epithelial cells which promotes neutrophil migration. Proc. Natl. Acad. Sci. USA 2000; 97:12283-12288.
4. Criss, AK, Ahlgren, DM, Jou, T-S, McCormick, BA., and Casanova, JE. The GTPase Rac1 selectively regulates Salmonella invasion at the apical plasma membrane of polarized epithelial cells. J. Cell Sci. 2001; 114: 1331-1341.
5. Fernandez, I, Maurelli, AT, Silva, M, Siber, AM, Schuch, R, W. Allan Walker, and McCormick, BA. Cadaverine prevents the escape of Shigella flexneri from out of the phagolysosme: A connection between bacterial dissemination and neutrophil transepithelial signaling. J. Infect. Dis. 2001; 184: 743-753.
6. Criss, A, Silva, M, Casanova, J, and McCormick, BA. Regulation of Salmonella- induced neutrophil transmigration by epithelial ADP-ribosylation factor 6. J. Biol. Chem. 2001; 276: 48431-48439.
7. Kohler, H, Rodriques, SP, and McCormick, BA. Shigella flexneri interactions with the basolateral membrane domain of polarized model intestinal epithelium: Role of lipopolysaccharide in cell invasion and in activation of the mitogen- activated protein kinase ERK. Infect. Immun. 2002;70: 1150-1158.
8. Takanori S, Köhler, H, Gu, X, McCormick, BA and Reinecker H-C. Shigella flexneri regulates tight junction associated proteins in human intestinal epithelial cells. Cell. Microbiol. 2002; 4: 367-381.
9. Kohler H, Rodrigues, SP, Maurelli AT, and McCormick, BA. Inhibition of Salmonella typhimurium enteropathogenicity by piperidine, a metabolite of the polyamine cadaverine. J. Infect. Dis. 2002; 186:1122-1130.
10. Nadeau WJ, Pistole, TG, and McCormick, BA. Polymorphonuclear leukocyte migration across model intestinal epithelial enhances Salmonella typhimurium killing via the epithelial derived cytokine, IL-6. Microbes Infect. 2002; 4:1379-1387.
11. Hisamatsu, T., Suzuki, M., Reinecker, H-C., Nadeau, W.J., McCormick, B. A., Podolsky, D.K. Card15/Nod2 functions as an anti-bacterial factor in human intestinal epithelial cells. Gastroenterology 2003; 124:993-1000.
12. Silva, M., Song, C., Nadeau, W.J., Matthews, J.B., McCormick, B.A. Salmonella typhimurium SipA-induced neutrophil transepithelial migration: involvement of a PKC-a dependent signal transduction pathway. Am. J. Physiol. Gastrointest. Liver Physiol. 2004; 286:G1024-G1031.
13. Mrsny, R.J., Gewirtz, A.T. , Siccardi,,D., Savidge, T.C., Hurley, B.P., Madara, JL, and McCormick, B.A. Identification of hepoxilin A3 in inflammatory events: A required role in neutrophil migration across the intestinal epithelia. Proc. Natl. Acad. Sci. USA 2004; 101: 7421-7426.
14. Tenor, J.L., McCormick, B.A., Ausubel, F.M., Aballay, A. Caenorhabditis elegans-Based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions. Curr. Biol. 2004; 14:1018-1024.
15. Hurley, B.P., Siccardi, D., Mrsny, R.J., McComick, B.A. PMN transepithelial migration induced by Pseudomonas aeruginosa requires the eicosinoid hepoxilin A3. J. Immunol. 2004; 173:5712-5720.
16. Niess, J.H., Brand, S., Gu, X., Landsman, L., McCormick, B.A., Vyas, J.M., Boes, Ploegh, H.L., Fox, J.G., Littman, D.R., Reinecker, H-C. Control of dendritic cell access to the intestinal lumen and of bacterial clearance by CX3CR1. Science 2005; 307; 254-258.
17. Chen, C.C., Louie, S., McCormick, B.A., Walker, W.A., Shi, H.N. Concurrent infection of an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infect. Immun. 2005; 73: 5468-81.
18. Chen, C.C., Louie, S., McCormick, B.A., Walker, W.A., Shi, H.N. Helminth primed dendritic cells alter the host response to enteric bacterial infection. J. Immunol.2006;176(1):472-83.
19. Hurley, B.P., Williams, N., McCormick, B.A. Involvement of phospholipase A2 in Pseudomonas aeruginosa mediated PMN transepithelial migration. Am. J. Physiol. Lung Cell. Mol. Physiol. 2005 [in press]; Nov 4 ePub ahead of print.
20. Savidge, T.C., Newman, P.G., Pan, W-H, Weng, M.Q., Shi, H.N., McCormick, B.A., Quaroni, A., Walker, W.A. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling. J. Pediatr. Res. 2006;59(1):89-95.
21. Salazar-Gonzalez, R.M., Niess, J.H., Zammit, D.J., Ravindran, R., Srinivasan, A., Maxwell, J.R., Stoklasek, T., Yadav, R., Williams, I.R., Gu, X., McCormick, B.A., Pazos, M.A., Vella, A.T., Lefrancois, L., Reinecker, H-C., McSorley, S.J. CCR6-mediated dendritic cell activation of pathogen specific T cells in Peyer’s patches. In Press Immunity
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Nanda Nanthakumar, PhD
1. Dai D, NN Nanthakumar, DS Newburg, WA Walker. (2000) The role of oligosacharides and glycoconjugates in intestinal host defense. J. Pediatr. Gastr. Nutr. 30: S23-S33.
2. Nanthakumar NN, RD Fusunyan, IR Sanderson, WA Walker (2000) Endotoxin interaction with the developing human intestine: Pathophysiologic basis for necrotizing enterocolitis. Proc Natl Acad Sci., 97: 6043-6048.
3. Beck PL, R Xavier, N Lu, NN Nanthakumar, M Dinauer, Dk Podolsky, B Seed (2000) Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice. Gastroenterology 119:699-705
4. Fusunyan R, NN Nanthakumar, Baldeon, ME, Walker WA. (2001) Evidence for an innate immune response in the immature intestine: Toll-like receptors on fetal enterocytes. Pediatric Research 49:589-593
5. Nanthakumar NN. (2001) The Regulation of functional development of the small intestine. In: Gastrointestinal functions, Ed: E. Delvin and MJ Lentze. Nestlé Nutrition Workshop Series, Vol 46, Nestlé Ltd., Vevey/Lippincott Williams & Wilkins, Philadelphia: pp 39-58.
6. Dai D, NN Nanthakumar, T Savidge, DS Newburg, WA Walker. (2002) Tissue specific developmental regulation and cortisone induction of glycosyltransferase in the developing mouse intestine. I. alpha 2,6-sialytransferase. Am. J. Physiol. 282: G480–G490.
7. Nanthakumar NN, D Dai, DS Newburg, WA Walker. (2003) The induction of glycosyltransferases by colonizaing bacteria in germ free animal. The FASEB J.: G480–90.
8. Nanthakumar NN, CE Klopcic, I Fernandez, and Walker WA. (2003) Normal and glucocorticoid induced development of the human jejunal and ileal xenografts. Am. J. Physiol. 285: R162-70.
9. Nanthakumar N, Walker WA. (2003) Human intestinal development and maturation. In The small intestine Ed: MN Marsh and EMM Quiqley, Academic Press, pp 1-24.
10. Nanthakumar N, Walker WA. (2004) The role of Bacteria in the Development of Intestinal Protective Function. In: Allergic Diseases and the Environment, Ed: W. A. Walker and E. Isolauri. Nestlé Nutrition Workshop Series, Vol 53, Nestlé Ltd., Vevey/Lippincott Williams & Wilkins, Philadelphia, pp 153–178.
11. Nanthakumar NN, D Dai, D Meng, N. Chaudry, DS Newburg, WA Walker. (2005) Regulation of Intestinal Ontogeny: Effect of glucocorticoids and luminal microbes on Galactosyltransferase and Trehalase induction in mice. Glycobiology, 15(3):221-232.
12. Nanthakumar NN, C Young, JS Ko, D Meng, J Chen, T Buie, W.A Walker. (2005) Glucocorticoid responsiveness in the developing human intestine: A possible role in the prevention of necrotizing enterocolitis. Am. J. Physiol.; 288(1):G85-92.
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David Newburg , PhD
1. Shen Z, Warren CD, Newburg DS. High-performance capillary electrophoresis of sialylated oligosaccharides of human milk. Anal Biochem 2000;279:37-45.
2. Bulik DA, van Ophem P, Manning JM, Shen Z, Newburg DS, Jarroll EL. UDP-N-acetylglucosamine pyrophosphorylase, a key enzyme in encysting Giardia, is allosterically regulated. J Biol Chem 2000;275:14722-8.
3. Eisenhauer PB, Chaturvedi P, Fine RE, Ritchie AJ, Pober JS, Cleary TG, Newburg DS. TNF-a increases human cerebral endothelial cell Gb3 and sensitivity to Shiga toxin. Infect Immun 2001;69:1889-94.
4. Chaturvedi P, Warren CD, Altaye M, Morrow AL, Ruiz-Palacios GM, Pickering LK, Newburg DS. Fucosylated human milk oligosaccharides vary among individuals over the course of lactation. Glycobiology 2001;11:365-72.
5. Shen Z, Warren CD, Newburg DS. Resolution of structural isomers of sialylated oligosaccharides by capillary electrophoresis. J Chromatogr A 2001;921(2):315-21.
6. Wiederschain GY, Newburg DS. Glycoconjugate stability in human milk: glycosidase activities and sugar release. J Nutr Biochem 2001;12:559-64.
7. Dai D, Nanthakumar NN, Savidge TC, Newburg DS, Walker WA. Region-specific ontogeny of a2,6 sialyltransferase during normal and cortisone-induced maturation in the mouse intestine. Am J Physiol Gastrointest Liver Physiol 2002;282:G480-90.
8. Nanthakumar NN, Dai D, Newburg DS, Walker WA. The role of indigenous microflora in the development of murine intestinal fucosyl- and sialyltransferases. FASEB J (November 15, 2002) 10.1096/fj.02-0031fje (summary: FASEB J 2003;17:44-6).
9. Ruiz-Palacios GM, Cervantes LE, Ramos P, Chavez-Munguia B, Newburg DS. Campylobacter jejuni binds intestinal H(O) antigen (Fuca1,2Galb1,4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection. J Biol Chem. 2003;278:14112-20.
10. Huang P, Farkas T, Marionneau S, Zhong W, Ruvoën-Clouet N, Morrow AL, Altaye M, Pickering LK, Newburg DS, LePendu J, Jiang X. Noroviruses bind to human ABO, Lewis and secretor histo-blood group antigens: Identification of four distinct strain-specific patterns. J Infect Dis 2003;188:19-31.
11. Newburg DS, Ruiz-Palacios GM, Altaye M, Chaturvedi P, Meinzen-Derr J, Guerrero ML, Morrow AL. Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants. Glycobiology 2004;14(3):253-63. Published erratum Glycobiology 14(5):13G.
12. Sener K, Shen Z, Newburg DS, Jarroll EL. Levels of amino sugar phosphate intermediates in Giardia change during encystment. Microbiology 2004;150:1225-30.
13. Eisenhauer PB, Jacewicz MS, Conn KJ, Koul O, Wells JM, Fine RE, Newburg DS. Escherichia coli Shiga toxin 1 and TNF-a induce cytokine release by human cerebral microvascular endothelial cells. Microb Pathog 2004;36:189-96.
14. Morrow AL, Ruiz-Palacios GM, Altaye M, Jiang X, Guerrero ML, Meinzen-Derr JK, Farkas T, Chaturvedi P, Pickering LK, Newburg DS. Human milk oligosaccharides are associated with protection against diarrhea in breastfed infants. J Pediatr 2004;145:297-303.
15. Jiang X, Huang P, Zhong W, Tan M, Farkas T, Morrow AL, Newburg DS, Ruiz-Palacios GM, Pickering LK. Human milk contains elements that block binding of Noroviruses to human histo-blood group antigens in saliva. J Infect Dis 2004;190:1850-9.
16. Nanthakumar NN, Dai D, Meng D, Chaudry N, Newburg DS, Walker WA. Regulation of intestinal ontogeny: Effect of glucocorticoids and luminal microbes on galactosyltransferase and trehalase induction in mice. Glycobiology 2005;15(3):221-232
17. Newburg DS. Innate immunity and human milk. J Nutr (Suppl) 2005;135:1310-4.
18. Morrow AL, Ruiz-Palacios GM, Jiang X, Newburg DS. Human milk glycans that inhibit pathogen binding protect infants against infectious diarrhea. J Nutr (Suppl) 2005;135:1306-10.
19. Newburg DS, Morrow AL, Ruiz-Palacios GM. Human milk glycans protect infants against enteric pathogen. Annu Rev Nutr 2005;25:2537-58.
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Harry Pothoulakis, MD
1. Castagliuolo I, Karalis K, Valenick L, Pasha A, Nikulasson S, Pothoulakis C. Endogenous corticosteroids modulate Clostridium difficile toxin A – mediated enteritis in rats. Am J Physiol 2001;280: G539-G545.
2. Qamar A, Warny M, Michetti P, Pothoulakis C, JT LaMont, Kelly CP. Saccharomyces boulardii stimulates an intestinal IgA immune response to Clostridium difficile toxin A in mice. Infect Immun, 2001;69: 2762-65.
3. Kirkwood SK, Bunnett NW, Castagliuolo I, Liu B, Gerard N, Zacks J, Pothoulakis C, Grady EF. Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile Toxin A. Am J Physiol. 2001;281:G544-G551.
4. Zhao D, Keates A, Kuhnt-Moore S, Moyer MP, Kelly CP, Pothoulakis C. Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes J Biol Chem 2001;276:44464-
5. Chen ML, Pothoulakis C, LaMont JT. PKC signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A. J. Biol. Chem 2002;277:4247-4254.
6. Morteau O, Castagliuolo I, Zacks J, Lu B, Pothoulakis C*, Gerard NP, Gerard C. Genetic deficiency in the chemokine receptor CCR1 protects against Clostridium difficile toxin A enteritis in mice. Gastroenterology, 2002; 122:725-733. * Corresponding Author.
7. Agarwal B, Halmos B, Feoktistov AS, Protiva P, Ramey GR, Pothoulakis C, LaMont JT, Holt PR. Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells. Carcinogenesis, 2002;23:521-528.
8. He D, Sougioultzis S, Hagen S, Liu J, Keates S, Keates AC, Pothoulakis C, LaMont JT. Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. Gastroenterology, 2002;122:1048-57.
9. Castagliuolo I, Morteau O, Keates AC, Valenick L, C-C Wang, Zacks J, Lu B, Gerard NP, Pothoulakis C. Protective effects of NK-1 receptor during colitis in mice: role of the epidermal growth factor receptor. Br J Pharmacol., 2002;136: 271-279.
10. Wlk M, Karalis K, Wang C-C, Venichaki M, Liu J, Zhao D, Zacks J, Pothoulakis C. Corticotropin- releasing hormone is a proinflammatory peptide in the mouse ileum. Gastroenterology, 2002;123:505-15.
11. Zhao D, Kuhnt-Moore S, Zeng H, Pan A, Wu J, Simeonidis S, Pothoulakis C. Substance P- stimulated interleukin-8 expression in human colonic epithelial cells involves activation of MAP kinases and Rho GTPases. Biochem J, 2002;368:665-72.
12. Mykoniatis A, Anton PP, Wlk M, Wang CC, Ungsunan L, Blueher S, Venihaki M, Simeonidis S, Zacks J, Zhao D, Sougioultzis S, Karalis K, , Mantzoros M, Pothoulakis C. Leptin mediates Clostridium difficile- induced enteritis in mice. Gastroenterology 2003;124:683-91
13. Simeonidis S, Castagliuolo I, Pan A, Leu J, Wang C-C, Mykoniatis A, Pasha A, Valenick L, Sougioultzis S, Zhao D, Pothoulakis C. Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-kB site on its promoter. Proc Natl Acad Sci (USA), 2003;100:2957-62.
14. Liu TS, Musch MW, Sugi K, Hendrickson B, Pothoulakis C, LaMont JT, Chang EB. Cytoprotective role of heat shock protein 72 against Clostridium difficile toxin A-induced intestinal dysfunction. Am J Physiol (Cell) 2003; 284:C1073-82.
15. Zhao D, Kuhnt-Moore S, Zeng H, Wu JS, Moyer MP, Pothoulakis C. Neurotensin stimulates interleukin-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kB pathways. Am J Physiol (Cell) 2003;284:C1397-404.
16. Savidge T, Pan W, Newman P, O’Brien M, Pothoulakis C. Clostridium difficile toxin B is an enterotoxin for human intestine in vivo. Gastroenterology 2003; 125:413-20.
17. Lu L, Baldeon ME, Savidge T, Pothoulakis C, Walker WA. Development of microbial-human enterocyte interaction: cholera toxin. Pediatr Res 2003; 54:212-8.
18. Stucchi AF, Shebani KO, Leeman SE, Wang CC, Reed KL, Fruin AB, Gower AC, McClung JP, Andry CD, O'Brien MJ, Pothoulakis C, Becker JM. A Neurokinin 1 Receptor Antagonist Reduces an Ongoing Ileal Pouch Inflammation, and the Response to a Subsequent Inflammatory Stimulus. Am J Physiol 2003; 285:G1259-67.
19. Rhee SH, Keates AC, Moyer MP, Pothoulakis C. MEK is a key modulator for TLR5-induced IL-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. J Biol Chem 2004; 279:25179-88.
20. Anton PM, Gay J, Mykoniatis A, Pan A, O’Brien M, Brown D, Karalis K, Pothoulakis C. Corticotropin- releasing hormone (CRH) requirement in Clostridium difficile toxin A - mediated intestinal inflammation. Proc Natl Acad Sci (USA) 2004; 101: 8503-8508.
21. Anton PM, O’Brien M, Kokkotou E, Einsenstein B, Michaelis A, Rothstein D, Paraschos S, Kelly CP, Pothoulakis C. Rifalazil treats and prevents relapse of Clostridium difficile – associated diarrhea in hamsters. Antimicrob Agents Chemother 2004 48:3975-9.
22. Zhao D, Koon M, Zhan Y, Zeng H, Keates S, Moyer MP, Pothoulakis C. Metalloproteianse-dependent TGFa release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells. J Biol Chem 2004; 279: 43547-43554.
23. Riegler M., Cosentini E., Sedivy R., Sogukoglu T., Prettenhofer M, Bischof G., Pothoulakis C., Wenzl E. Hepatocyte Growth Factor Stimulates Epithelial Restitution in Rabbit Duodenum in vitro. Eur Surg, 2004; 36: 368-376
24. Koon HW, Zhao D, Na X, Moyer MP, Pothoulakis C. Metalloproteinases and transforming growth factor- alpha mediate substance-P induced mitogen-activated protein kinase activation and proliferation in human colonocytes. J Biol Chem 2004; 279:45519-45527.
25. Sougioultzis S, Kyne L, Drudy D, Keates S, Maroo S, Pothoulakis C, Giannasca PJ, Lee CK, Warny M, Monath TP, Kelly CP. Clostridium difficile toxoid vaccine in recurrent C. difficile associated diarrhea. Gastroenterology 2005;128:764-70..
26. Na X, Zhao D, Koon H-W, Kim H, Husmark J, Moyer MP, Pothoulakis C, LaMont JT. Clostridium difficile Toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes. Gastroenterology 2005; 128:1002-11.
27. Zhao D, Zhan Y, Zeng H, Koon H-W, Moyer MP, Pothoulakis C. Neurotensin stimulates interleukin-8 expression through modulation of IkBa phosphorylation and p65 transcriptional activity: involvement of protein kinase Ca. Mol Pharmacol 2005; 67:2025-31.
28. Bradesi S, Schwetz I, Ennes HS, Lamy CM, Ohning G, Fanselow M, Pothoulakis C, McRoberts JA, Mayer EA. Repeated exposure to water avoidance stress in rats: A new model for sustained visceral hyperalgesia. Am J Physiol, Gastrointest Liver Physiol. 2005; 289:G42-53.
29. Kim H, Rhee SH, Kokkotou E, Na X, Savidge T, Moyer MP, Pothoulakis C, LaMont JT. Clostridium difficile toxin A regulates inducible COX-2 and PGE2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAP kinase. J. Biol Chem 2005; 280:21237-45.
30. Koon H-W, Zhao D, Zhan Y, Moyer MP, Pothoulakis C. Substance P-stimulated interleukin-8expression in human colonic epithelial cells involves PKCd activation. J Pharmacol Exp Ther 2005; 314:1393-400
31. Rhee SH, Im E, Riegler M, Kokkotou M, O’Brien M, Pothoulakis C. Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci (USA), 2005; 102:13610-5
32. Kim H, Kokkotou E, Na X, Rhee SH, Moyer MP, Pothoulakis C, LaMont JT. Clostridium difficile toxin A- induced colonocyte apoptosis involves p53-dependent-p21(WAF1/CIP1) induction via p38 MAPK. Gastroenterology 2005; 129:1875-88.
33. Zhao D, Zhan Y, Zheng H, Moyer MP, Mantzoros C, Pothoulakis C. Ghrelin is upregulated in intestinal inflammation and stimulates NF-kB-dependent interleukin-8 expression in human colonic epithelial cells. J Cell Biochem, In press.
34. Bradesi S, Kokkotou E, Simeonidis S, Patierno S, Ennes HS, Mittal Y, McRoberts JA, Ohning G, Marvizon JC, Sternini C, Pothoulakis C, Mayer EA. The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats. Gastroenterology, In press.
35. Koon H-W, Zhao D, Zhan Y, Rhee SH, Moyer MP, Pothoulakis C. Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic Epithelial Cells. J Immunol, In Press.
36. Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O’Brien M, Leeman SE, Kirkland JL, Pothoulakis C. Induction of colitis causes inflammatory responses in mesenteric fat tissue: evidence for substance P-mediated pathways in human mesenteric preadipocytes. Proc Natl Acad Sci (USA), In Press.
37. Sougioultzis S, Simeonidis S, Bhaskar RK, Chen X, Anton PM, Keates S, Pothoulakis C, Kelly CP. Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochem Biophys Res Commun. In Press.
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Hai Ning Shi, DVM, PhD
1. James G. Fox, Paul Beck, Charles A Dangler, Mark T. Whary, Timothy C. Wang, Hai Ning Shi and Cathryn Nagler-Anderson. Concurrent enteric infection modulates inflammation, gastric immune responses, and reduces helicobacter-induced gastric atrophy. Nature Medicine. 2000; 6 (45): 536-542.
2. Hai Ning Shi, Hao Yuan Liu and Cathryn Nagler-Anderson. Enteric infection acts as an adjuvant for the response to a model food antigen. Journal of Immunology. 2000, 165: 6174-6182.
3. Cathryn Nagler- Anderson and Hai Ning Shi. Peripheral Nonresponsiveness to orally administered soluble protein antigens. Critical Reviews in Immunology. 2001. 21:121-131.
4. Bashir MEH, Andersen P., Fuss I.J., Shi H.N. and Nagler-Anderson C. An enteric helminth infection protects against allergic response to dietary antigen. Journal of Immunology 2002, 169: 3284-3292.
5. Hai Ning Shi and W. Allan Walker. T helper cell subclasses and clinical disease states. Current Opinion in Gastroenterology. 2002, 18(6): 711-716.
6. Bashir MEH, Louie S., Shi H.N. and Nagler-Anderson C. TLR4 signaling by intestinal microbes influences susceptibility to food allergy. Journal of Immunology. 2004. 172(11): 6978-87.
7. Shi HN, Walker A. Bacterial colonization and the development of intestinal defences. Can J Gastroenterol. 2004 Aug; 18(8): 493-500
8. Hai Ning Shi and W. Allan Walker. Bacterial colonization in the developing gastrointestinal tract: Role in the pathogensis of intestinal diseases. Bioscience Microflora. 2004, 23(2): 55-65.
9. Chien-Chang Chen, Hai Ning Shi and Allan Walker. Precolonization with probiotics Lactobacillus acidophilus NCFM at early life attenuates Citrobacter rodentium induced colitis in mice. Pediatric Research. 2005. 58 (6): 1185-1191.
10. Chien-Chang Chen, Steve Louie, Beth McCormick, Allan Walker and Hai Ning Shi. Concurrent infection of an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infection and Immunity. 2005. 73: 5468-5481.
11. Moran ST, Cariappa A, Liu H, Boboila C, Shi HN, Holland PM, Peschon JJ, Pillai S. Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations. Mol Immunol. 2005. Oct.24.
12. Annaiah Cariappa, Irina B. Mazo, Catharine Chase, Hai Ning Shi, Haoyuan Liu, Qian Li, Harris Rose, Harry Leung, Bobby J. Cherayil, Paul Russell, Ulrich von Andrian, and Shiv Pillai. Perisinusoidal B Cells in the Bone Marrow Participate in T-Independent Responses to Blood-Borne Microbes. Immunity. 2005. 23 (4): 397-407.
13. Tor C. Savidge, Paul G. Newman, Wei-Hua Pan, Mei-Qian Weng, Hai Ning Shi, Beth A. McCormick, Andrea Quaroni, W. Allan Walker. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signalling. Pediatric Research. 2006. 59 (1).
14. Chien-Chang Chen, Steve Louie, Beth McCormick, Allan Walker and Hai Ning Shi. Helminth primed dendritic cells alter the host response to enteric bacterial infection. The Journal of Immunology. 2006. 176:472-483.
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W. Allan Walker, MD
1. Nanthakumar N, Fusunyan RD, Sanderson IR, Walker WA. Inflammation in the developing human intestine: A possible pathophysiologic basis for necrotizing enterocolitis. PNAS 2000; 97(11):6043-6048.
2. Teitelbaum JE, Walker WA. The role of omega 3 fatty acids in intestinal inflammation. J Nutr Biochemistry 2001; 12:21-32.
3. Fusunyan R, Nanthakumar N, Baldeon, ME, Walker WA. Evidence for an innate immune response in the immature intestine: Toll-like receptors on fetal enterocytes. Pediatric Research 2001; 49(4):589-593.
4. Spiekermann G, Walker WA. Oral tolerance and its role in clinical disease. J Pediatr Gastro Nutr 2001; 32:237-255.
5. Claud E, Walker WA. Hypothesis: Inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis. FASEB J 2001; 15:1398-1403.
6. Savidge TC, Lowe DC, Walker WA. Developmental regulation of intestinal epithelial hydrolyase activity in human jejunal xenografts maintained in severe-combined immunodeficient mice. Pediatric Research 2001; 50(2):196-202.
7. Walker WA. New insights into the pathogenesis of food allergy. J Pediatr Gastr Nutr 2001; 33:101-102.
8. Fernandez IM, Nayreku AT, Silva M, Schuch R, Walker WA. Siber Am, McCormick BA. Cadaverine prevents the escape of Shigella flexneri from out of the phagolysosme: A connection between bacterial dissemination and neutrophil transepithelial signaling. J Infectious Disease 2001; 184:643-53.
9. Dai D, Nanthakumar N, Savidge TC, Newburg DS, Walker WA. Region-specific ontogeny of (2.6 sialytransferase during normal and cortisone-induced maturation in the mouse intestine. Am J Physiology 2002; 282:G480-G490.
10. Nanthakumar NN, Dai D, Newburg DS, Walker WA. (November 15, 2002) The role of indigenous microflora in the development of murine intestinal fucosyl- and siayltransferases. FASEB J.(November 15, 2002) 10.1096/fj.02-003 1fje (summary: FASEB J 2003; 17:44-46.
11. Uzma Shah, Blumberg RS, Simister NE, Lencer WI, Walker WA. The distribution of the IgG Fc receptor, FcRn, in the human fetal intestine. Ped Res 2003, 53(2):295-391.
12. Kohler H, McCormick BA, Walker WA. Bacterial-enterocyte crosstalk: Cellular mechanisms in health and disease. J Pediatr Gastr Nutr 2003; 36(2):175-185.
13. Claud EC, Savidge T, Walker WA. Modulation of human intestinal epithelial cell interleukin-8 secretion by human milk factors. Ped Res 2003; 53(3):419-425.
14. Buisane J-P, Aubert J-P, Walker WA, Savidge TC. Developmental patterns of mucin gene expression in human fetal small intestinal xenografts maintained in severe-combined immunodeficient mice. Ped Res, 2003 (in press).
15. Nanthakumar NN, Klopcic C, Walker WA. Normal and glucocorticoid induced development of the human small intestinal xenograft. Am J Physiology (Regulatory, Integrative and Comparative Physiology) 2003 (in press).
16. Lu L, Baldeon ME, Walker WA. Development of microbial-human enterocyte interaction: Cholera toxin. Ped Res 2003 (submitted).
17. Claud EC, Lu L, Anton PM, Savidge T, Walker WA, Cherayil BJ. Developmentally-regulated IkB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. PNAS 2004; 101(19):7404-7408.
18. Yuan Q, Walker WA. Innate immunity of the gut: Mucosal defense in health and disease. J Pediatr Gastro Nutr 2004; 38:463-472.
19. Huang F-C, Werne A, Li Q, Galyov EE, Walker WA, Cherayil BJ. Cooperative interactions between flagellin and SopE2 in the epithelial IL-8 response to Salmonella infection. Infec Immun 2004; 72:5052-5062.
20. Nanthakumar NN, Young C, Ko JS, Meng D, Chen J, Buie T, Walker WA. Glucocorticoid responsiveness in the developing human intestine: possible role in the prevention of necrotizing enterocolitis. AJP: GI and Liver Physiology 2005 288:G85-G92.
21. Nanthakumar NN, Dai D, Meng D, Chaudry N, Newburg DS, Walker WA. Regulation of intestinal ontogeny: effect of glucocorticoids and luminal microbes on galactosyltransferase and terehalase induction in mice. Glycobiology 2005; 15:221-232.
22. Forchielli ML, Walker WA. The role of GALT and mucosal defense. Br J Nutr
2005; 93:S41-S48.
23. Lu L, Khan S, Lencer W, Walker WA. Endocytosis of cholera toxin by human enterocytes is developmentally regulated. Am J Physiol Gastrointest Liver Physiol 2005; 289:G332-G341.
24. Rhee SJ, Walker WA, Cherayil BJ. Developmentally-regulated intestinal expression of IFNg and its target genes and the age-specific response to Salmonella infection. J Immunol 2005; 175:1127-1136.
25. Chen C-C, Louie S, McCormick B, Walker WA, Shi H. Concurrent infection of an intestinal helminth parasite impairs host resistance to Citrobacter rodentium and enhances Citrobacter-induced colitis mice. Infect Immun 2005; 73:5468-5481.
26. Chen C-C, Louie S, Shi H, Walker WA. Precolonization with the probiotic
lactobacillus acidophilus early in life effectively inhibits murine Citrobacter rodentium colits. Ped Res 2005; 58(6):1185-1191.
27. Savidge TC, Newman PG, Pan W-H, Weng M, McCormick, Quaroni A, Walker WA. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-meidated interleukin-8 production may occur independently of TLS-4/MD-2 signalling. Ped Res 2006;59:85-95.
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