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Laboratory Staff
Curriculum Vita
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Curriculum Vita
Beth McCormick, PhD  
Associate Professor of Pediatrics
GENERAL INFORMATION
Date Prepared: December, 2005
Name: Beth A. McCormick
Office Address:
Department of Pediatrics
Mucosal Immunology Laboratory
Massachusetts General Hospital and Harvard Medical School
114 16th Street 114-3503
Charlestown, MA. 02129
Phone: (617) 726-4168
FAX: (617) 726-4172
E-Mail: mccormic@helix.mgh.harvard.edu
Place of Birth: Great Barrington, MA USA
Education:
1986 B.A. University of New Hampshire, Durham NH
1990 Ph.D. University of Rhode Island, Kingston RI (Microbiology)
Postdoctoral Training:
Research Fellowships:
1990-1992 Research Fellow in Surgical Research, The Children's Hospital Medical Center, Harvard Medical School, Boston, MA
1992-1994 Research Fellow in Pathology and Medicine (Infectious Diseases), Brigham and Women's Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA
Academic Appointments:
1994-1997 Instructor of Pathology, Department of Pathology, Harvard Medical School, Boston, MA
1997-2002 Assistant Professor of Pediatrics and Microbiology, Harvard Medical School, Boston, MA
2002-present Associate Professor of Pediatrics and Microbiology, Harvard Medical School. Boston, MA
Hospital or Affiliated Institution Appointments:
1994-1997 Assistant in Experimental Microbiology, Gastrointestinal Pathology Unit, Brigham and Women’s Hospital, Boston, MA
1997- Associate Microbiologist, Pediatric Service, Massachusetts General Hospital, Boston, MA
1997- Research Faculty of the Center for the Study of Inflammatory Bowel Disease, Department of Gastroenterology, Massachusetts General Hospital, Boston, MA
2001- Director of Microbiology, Mucosal Immunology Laboratories, Combined Program in Pediatric Gastroenterology and Nutrition Massachusetts General Hospital, Boston, MA
2002- Research Faculty of the Harvard Medical School Fellowship in Pediatric Gastroenterology and Nutrition, Department of Pediatric Gastroenterology, The Children’s Hospital and Massachusetts General Hospital, Boston, MA
Major Administrative Responsibilities:
Sponsored Research Programs - Past:
1992-1994 NIH/Individual National Research Award
Intestinal Disease/Inflammation: Bacterial Interactions
Principal Investigator: Beth A. McCormick, Ph.D.
Sponsor: James L. Madara, MD
1994-1996 Pilot Feasibility Grant (Harvard Digestive Diseases Center)
Intestinal Disease: Bacterial Epithelial Signaling
Principal Investigator: Beth A. McCormick, Ph.D.
1994-1995 Career Development Award (Crohn's and Colitis Foundation of America) Novel Epithelial-Neutrophil Signaling Pathways in Inflammatory Bowel Disease
Principal Investigator: Beth A. McCormick, Ph.D.
Sponsor: James L. Madara, MD
1995-2000 National Institutes of Health R29 First Award (DK50989)
Intestinal Inflammation Orchestrated by Pathogens
Principal Investigator: Beth A. McCormick, Ph.D.
1999-2001 Crohn’s And Colitis Foundation of America
Research Grant: The Inhibition by Human Milk Sulfatides of Pathogen-Mediated Intestinal Inflammation
Principal Investigator: Beth A. McCormick, Ph.D.
1999-2001 Harvard Medical School Seed Grant
Studies on the Induction of IL-8 Secretion from Intestinal Epithelial Cells by Salmonella
Principal Investigator: Beth A. McCormick, Ph.D. and Catherine A. Lee, Ph.D.
2000-2005 National Institutes of Health R01 Research Grant
Intestinal Inflammation Orchestrated by Pathogens
Principal Investigator: Beth A. McCormick, Ph.D.
2000-2005 National Institutes of Health PO1 Research Grant
Barrier Function of the GI Tract in Health and Disease
W. Allan Walker, MD. Program Project Director
Principal Investigator of Project 3: Beth A. McCormick, Ph.D.
Sponsored Research Programs - Current:
2004-2006 Cystic Fibrosis Foundation
Identification of the Pseudomonas aeruginosa Factor Responsible for Inducing a Novel Inflammatory Pathway
Principal Investigator: Beth A. McCormick, Ph.D.
2005-2010 National Institutes of Health R01 Research Grant
Intestinal Inflammation Orchestrated by Pathogens
Principal Investigator: Beth A. McCormick, Ph.D.
2005-2010 National Institutes of Health PO1 Research Grant
Barrier Function of the GI Tract in Health and Disease
W. Allan Walker, MD. Program Project Director
Principal Investigator of Project 3: Beth A. McCormick, Ph.D.
Committee Assignments:
Harvard Medical School
2002-2005 Steering Committee: Harvard Medical School Fellowship in Pediatric Gastroenterology and Nutrition
Affiliated Institutions
1997- Member of the Center for the Study of Inflammatory Bowel Disease Gastroenterology Unit, Massachusetts General Hospital
2001- Operations Committee Member Massachusetts General Hospital
2002-2003 Member of Massachusetts General Hospital Emergency Response Team
Regional
1990 Faculty Excellence Award Committee, University of Rhode Island
National
2002- Convener, Session: Microbial Interactions with Polarized Epithelia American Society of Microbiology, Washington, D.C.
2003- Ad –Hoc Member of National Center for Complementary and Alternative Medicine Scientific Review Panel, National Institute of Health, Bethesda, MD.
2003 Panel member for Crohn’s and Colitis Foundation Research Initiative Award, New York, NY.
2003 Ad-Hoc Member of the BM-1 study section, National Institutes of Health, Bethesda, MD.
2004 Panel Member for the Junior Faculty Symposium, Northwestern University, Chicago, IL .
2005 Co-chair, Session on Intestinal Infections, American Gastroenterology Association General Meeting, Chicago, IL
2005 Co-Chair, Session on Intestinal Infections, Society of Mucosal Immunology Meeting, Boston, MA
2005 Panel Member for the Junior Faculty Symposium, John Hopkins University, Baltimore, MD.
2005 Ad –Hoc Member of National Center for Complementary and Alternative Medicine Scientific Review Panel, National Institute of Health, Bethesda, MD (October Study Section).
2005 Center for Scientific Review Special Emphasis Panel on Bacterial Pathogenesis, National Institute of Health, Bethesda, MD.
2006 National Institute of Health/National Cancer Institute: NCI PO1 Review Panel, National Cancer Institute, Bethesda, MD.
2006 Ad –Hoc Member of National Center for Complementary and Alternative Medicine Scientific Review Panel, National Institute of Health, Bethesda, MD (March Study Section).
2007 Co-Organizer of the FASEB Conference on the Gastrointestinal Tract XII
Memberships in Professional Societies:
1987 Society for Microbial Ecology and Disease (Member)
1987 American Society of Microbiology (Member)
1991 American Society for Cell Biology (Member)
1991 American Association for the Advancement of Science (Member)
2002- American Gastroenterology Association (Member)
2004- Mucosal Immunology Society (Member)
2005- American Society for Biochemistry and Molecular Biology (Member)
Editorial Boards:
2003- Editorial Board Member Infection and Immunity
2006- Editorial Board Member Journal of Biological Chemistry
1999- Ad Hoc Reviewer Cellular Microbiology
1997- Ad Hoc Reviewer Gastroenterology
1997- Ad Hoc Reviewer Journal of Pediatric Research
1997- Ad Hoc Reviewer American Journal of Physiology
1997- Ad Hoc Reviewer Gut
1997- Ad Hoc Reviewer Journal of Immunology
1997- Ad Hoc Reviewer Journal of Clinical Investigation
Honors and Awards:
1986 Phi Gamma Mu International Honor Society
1988 Phi Kappa Phi Honor Society (awarded to graduate student with highest GPA)
1992 National Research Service Award
1994 Harvard Digestive Disease Award
1992 Crohn's and Colitis Foundation of America Career Development Award
1997 Center for the Study of Inflammatory Bowel Disease
2001 Partners in Excellence Award Recipient
RESEARCH, TEACHING AND CLINICAL CONTRIBUTIONS
A. Narrative Report:
My research is focused on the molecular mechanisms by which the enteric pathogens Salmonella typhimurium and Shigella flexneri induce mucosal inflammatory responses. Such inflammatory responses lead to active states of intestinal inflammation and are a hallmark feature of the disease pathophysiology of inflammatory bowel diseases such as bacterial enterocolitis, Crohn’s Disease, and ulcerative colitis. My original interest in this field of research lead to the development of a novel model system to examine the immunopathology of intestinal inflammation in vitro. My findings from these studies were the first to demonstrate that a pro-inflammatory program, which could recruit inflammatory cells (neutrophils), was orchestrated by epithelial cells in response to enteric pathogens. This work led to the identification of distinct chemokines released from intestinal epithelial cells, which work in concert to direct neutrophil movement into the intestinal lumen in response to enteric pathogens. Research projects in my laboratory are now directed at unraveling the molecular nature of these signals.
In 2001, I was appointed Director of Microbiology of the Mucosal Immunology Laboratories at Massachusetts General Hospital, under the direction of Dr. W. Allan Walker. In this capacity I oversee the day-to-day general operations of the research laboratories in mucosal immunology and developmental gastroenterology. My major responsibilities involve administering the research and development of the Microbiology program within the Mucosal Immunology Laboratories as well as directing the general operations of the Mucosal Immunology Laboratory. I am also a member of the Operations Committee at Massachusetts General Hospital. In this capacity I serve as a liaison between the Mucosal Immunology Laboratories and Research Space Management. For my role in serving on this committee and the work that I accomplished in this regard, I was awarded the Partners in Excellence Award. Most recently, I was elected to serve on the Massachusetts General Hospital emergency response team.
B. Funding Information - Current:
2005-2010 National Institutes of Health R01 Research Grant (DK56754)
Intestinal Inflammation Orchestrated by Pathogens
Principal Investigator: Beth A. McCormick, Ph.D.
2005-2010 National Institutes of Health PO1 Grant (DK33506)
Barrier Function of the GI Tract in Health and Disease
Beth A. McCormick, Ph.D., Principal Investigator of Program Project Grant III.
Harry Poutolakis, M.D. Program Director
2004-2006 Cystic Fibrosis Foundation
Identification of the Pseudomonas aeruginosa Factor Responsible for Inducing a Novel Inflammatory Pathway
C. Report of Current Research Activities:
Current research activities are, at the moment, exclusively focused on bench research. This research is funded by an NIH RO1 and a PO1 award and is focused on dissecting the molecular mechanisms by which enteric pathogens induce mucosal inflammatory responses. Ultimately, results obtained from both of these research projects will provide valuable insight into novel mechanisms of bacterial pathogenesis as well as establish clues for developing novel treatment strategies for active inflammation found in patients with infectious, allergic, and idiopathic colitis.
The RO1 funded project entitled "Intestinal Inflammation Orchestrated by Pathogens" is an extension of my previous work, which demonstrated that intestinal epithelial cells respond to lumenal pathogens, such as S. typhimurium, by releasing distinctive proinflammatory chemoattractants, which sequentially orchestrate PMN movement across the intestinal epithelium. I have found that S. typhimurium-intestinal epithelial cell interactions induce the epithelial synthesis and polarized basolateral release of the potent PMN chemokine, interleukin-8 (IL-8). Such basolateral release of IL-8 imprints subepithelial matrices with long-lived haptotactic gradients that function to guide PMN through the lamina propria to a subepithelial position. However, basolateral release of this chemokine is insufficient to induce migration of PMN across the intestinal epithelium, suggesting that the production of other inflammatory mediator(s), whose release would be polarized apically, are important for the execution of this step in the inflammatory pathway. Recently, I have identified the first such proinflammatory mediator called pathogen elicited epithelial chemoattractant (PEEC), which we have recently identified as the eicosanoid hepoxilin A3. Thus, the general goal of the RO1 funded project is to sort out the molecular and cellular mechanisms by which S. typhimurium induces the epithelial secretion of hepoxilin A3.
I am also the Principal Investigator of Project 3 on a NIH PO1 grant. Project 3 is entitled "Shigellosis. Role of the intestinal epithelium" and is focused on how Shigella flexneri are able to coordinate the mucosal immune response, which leads to an intense inflammatory reaction in humans characterized by bacillary dysentery. The research goals proposed are directed at (i) understanding the nature of the species dependency of Shigella with the human intestine, and (ii) elucidating the molecular basis by which Shigella foster acute infectious colitis. Our studies employ a patho-evolutionary approach and have lead to novel observations with regard to S. flexneri induced-inflammation. These observations support the concept that Shigella evolved from non-pathogenic ancestors by the loss of genes that are incompatible with virulence. Research in my laboratory sponsored by the PO1 award is now directed at exploiting these genes as a molecular tool to unlock the molecular mechanism by which Shigella induces an intense inflammatory response.
The newest project in my lab, sponsored by the Cystic Fibrosis Foundation, focuses on bacterial infections of the lung, another mucosal surface. Lung disease as a consequence of bacterial infection in many situations is marked by severe inflammation, particularly the accumulation of large numbers of neutrophils in the lumenal space along the respiratory tract. It is currently unclear what bacterial factors can trigger this response and exactly how the neutrophils are directed to the site of infection. Understanding this process is the broad long-term objective of our work.
D. Report of Teaching:
1. Local contributions:
a. Teaching responsibilities:
2005- Teach problem-based learning case studies in Immunology, Microbiology and Infectious Diseases to first year medical students.
b. Advisory and supervisory responsibilities in the laboratory setting:
1996-current: Supervise and mentor graduate students as well as Post Doc and MD fellows in the laboratory. This role involves intimate interactions with the trainees in the lab and includes both research and development (1500 hours/year). This role also includes serving as a member of several Thesis Advisory Committees.
c. Mentored Responsibilities - Past:
Alison Criss
Ph.D. candidate
Post-Doctoral Fellow, Dept. of Microbiology, (Co-mentored with James E. Casanova) Northwestern, Chicago IL
Rose Ann Murray
Ph.D. candidate
Post-Doctoral Fellow, Center for International Public Health, NJ
Isabel Fernandez
Post-doctoral fellow A
ssistant Professor, University of Barcelona, Barcelona, Spain
Henrik Köhler M.D.
Research fellow
Assistant Professor, University Children’s Hospital, Dusseldorf, Germany
Jasleen Jasleen M.D.
Research fellow
Clinical Fellow, Department of Surgery, Brigham and Women’s Hospital, Boston MA.
Sonia Rodrigues - Undergraduate trainee, Graduate Student, MacMaster University
Benjamin Case - Undergraduate trainee Medical Student, Boston University
Maytinee Lilaonitkul - Undergraduate trainee, Medical Student, Cambridge University, UK
Natecia Williams - Undergraduate trainee, Research Associate, University of Chicago
Patrick Murphy - Undergraduate trainee, Medical Student, University of Chicago
Jennifer Pesko - Undergraduate trainee, Applying to Medical School
d. Ph.D. Thesis Advisory Committees:
1999-2001: William Nadeau (Thomas Pistole, Ph.D. mentor); Department of Microbiology, University of New Hampshire, Durham, N.H.
2004- current: Jason Hendle (Marsha Goldberg, M.D., mentor); Department of Microbiology and Bacterial Genetics, Harvard Medical School
2005- current: Christina Clarke (Anthony T. Maurelli, Ph.D. mentor); Department of Microbiology and Immunology, The Uniformed Services University of the Health Sciences, Bethesda, MD.
2. Regional, national, or international contributions
a. Invited presentations
Regional:
1995 Seminar Speaker University of Rhode Island, Department of Microbiology, Kingston, RI
1996 Invited Speaker Symposium: Center for the Study of Inflammatory Bowel Diseases, Boston, MA
1998 Seminar Speaker, Shriners Burn Institution, Department of Biomedical Engineering, Boston, MA
1999 Seminar Speaker, University of New Hampshire, Department of Microbiology, Durham, NH
1999 Invited Speaker, Symposium: Center for the Study of Inflammatory Bowel Diseases, Boston, MA
2000 Invited Speaker, Harvard Digestive Disease Symposium, Boston, MA
2000 Seminar Speaker, Beth Israel New England Deaconess Hospital, Department of Medicine, Boston, MA
2004 Invited Speaker, Harvard Digestive Disease Center Symposium, Harvard Medical School, Boston, MA
2005 Seminar Speaker, Department of Gastroenterology, Children’s Hospital, Boston MA
National:
1994 Invited Lecture FASEB Conference [Gastrointestinal Tract: Cell and Molecular Biology, Copper Mountain, CO
1996 Seminar Speaker, Uniformed Services of the Health Sciences University, Department of Microbiology and Immunology, Bethesda, MD
1996 Seminar Speaker, Washington University School of Medicine, Department of Medicine, St. Louis, MO
1999 Seminar Speaker, University of Texas Medical Branch, Department of Microbiology, Galveston, TX
2000 Invited Speaker, Controlled Release Society Meeting, Intracellular Drug Delivery Workshop, San Diego, CA
2000 Seminar Speaker, Department of Pathology, Emory University School of Medicine, Atlanta, GA
2002 Invited Speaker, FASEB Conference [Microbial Pathogenesis: Mechanisms of Infectious Disease] August 10-15 Snowmass, CO
2003 Invited Speaker and Convener
Session Title: Microbial Interactions with Polarized Epithelia
American Society of Microbiology
Washington, D.C. May, 2003
2003 Plenary Session Speaker
Host-Pathogen Interactions
American Gastroenterology Association
Orlando, FL May 2003
2004 Seminar Speaker
Department of Microbiology and Molecular Genetics
Medical College of Wisconsin
Milwaukee, WI
2004 Seminar Speaker
Department of Microbiology
Texas A&M University
College Station, TX
2004 Seminar Speaker
Department of Microbiology
Tulane University
New Orleans. LA
2005 Seminar Speaker
Department of Microbiology and Immunology
Uniformed Services University of the Health Sciences
Bethesda, MD
2005 Invited Speaker
FASEB Conference [Gastrointestinal Tract XI: Innovations in GI Research & Therapy] August 13-18
Snowmass Village, Colorado
2005 Seminar Speaker
Section of Digestive Diseases and Nutrition
University of Illinois at Chicago
Chicago, IL
International:
1995 Invited Speaker
European Society of Pediatric Gastroenterology and Nutrition
Jerusalem, Israel
2002 Invited Speaker
Infectious Disease and Microbiology Research Day
University of Toronto
Toronto, Ontario
2003 Invited Speaker
Salmonella: Pathogenesis, Epidemiology, and Vaccine Development Meeting
Sardinia, Italy September 2003
2003 Seminar Speaker
Institute for Animal Health
Compton England
United Kingdom
2003 Seminar Speaker
Department of Pharmacology
Cardiff University
Wales, England
United Kingdom
2004 Invited Speaker
EMBO Workshop: Epithelial Polarity in Development and Disease
Carry-le-Rouet,
France
March 27-31
BIBLIOGRAPHY
Original Articles:
1. McCormick BA, Stocker BAD, Laux DC, Cohen PS. Roles of motility, chemotaxis, penetration through and growth in intestinal mucus in the ability of an avirulent strain of S. typhimurium to colonize the streptomycin-treated mouse large intestine. Infect. Immun. 1988; 50:2209-2217.
2. McCormick BA, Franklin DP, Laux DC, Cohen, PS. Type 1 pili are not necessary for the colonization of the streptomycin-treated mouse large intestine by type 1 piliated E. coli F-18 and E. coli K-12. Infect. Immun. 1989;57:3022-3029.
3. McCormick BA, Laux DC, Cohen PS. Neither motility nor chemotaxis play a role in the ability of E. coli F-18 to colonize the streptomycin-treated mouse large intestine. Infect. Immun. 1990; 59:2957-2961.
4. Krogfelt KA, McCormick BA, Laux DC, Cohen PS. Expression of E. coli F-18 type 1 fimbriae in the streptomycin-treated mouse large intestine. Infect. Immun. 1991; 59:1567-1568.
5. Kantor JD, McCormick BA, Steeg PS, and Zetter BR. Inhibition of cell motility after nm 23 transfection of human and murine tumor cells. Cancer Res. 1993;53: 1917-1973.
6. McCormick BA, Klemm P, Krogfelt KA, Burghoff RL, Pallesen L, Laux DC, Cohen PS. Escherichia coli F-18 phase-locked "on" for expression of type-1 fimbriae is a poor colonizer of the streptomycin-treated mouse large intestine. Microb. Pathogenesis. 1993; 14: 33-43.
7. McCormick BA, Colgan SP, Delp-Archer C, Miller SI, and Madara, JL. Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signaling to subepithelial neutrophils. J. Cell Biol. 1993; 123: 895- 907.
8. McCormick, BA, Miller, SI, Carnes, D, Madara, JL. Transepithelial signaling to neutrophils by Salmonellae: A novel virulence mechanism for gastroenteritis. Infect. Immun. 1995; 63: 2302-2309.
9. McCormick, BA, Hofman PM, Kim J, Carnes, DK, Miller, SI, Madara, JL. Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils. J. Cell Biol. 1995; 131: 1599-1608.
10. Sweeney, NJ, Klemm, P, McCormick, BA, Moller-Nielsen, E, Utley, MJ, Schembri, MA, Laux, DC, and Cohen, PS. The Escherichia coli K-12 gntP gene allows E. coli F-18 to occupy a distinct nutritional niche in the streptomycin- treated mouse large intestine. Infect. Immun. 1996; 64: 3497-3503.
11. McCormick, BA, Nusrat, A, D'Andrea, L, Parkos, CA, Hofman, PM, Carnes, DK, and Madara, JL. Unmasking of intestinal epithelial lateral membrane b1 integrin consequent to transepithelial neutrophil migration in vitro facilitates inv- mediated invasion by Yersinia. Infect. Immun. 1997; 65: 1414-1421.
12. McCormick, BA, Parkos, CA, Colgan, SP, Carnes, DK, and Madara, JL. Apical secretion of a pathogen-elicited epithelial chemoattractant (PEEC) activity in response to surface colonization of intestinal epithelia by Salmonella typhimurium. J. Immunol. 1998; 160: 455-466.
13. Gewirtz, A, McCormick, BA, Petasis, NA, Gronert, K, Serhan, CN, and Madara, JL. Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs. J. Clin. Invest. 1998; 101:1860-1869.
14. Shaw, SK, Hermanowski-Vosatka, A, Takeshi, S, McCormick, BA, Parkos, CA, Carlson, SL, Ebert, EC, Brenner, MB and Madara, JL. Migration of intestinal intra-epithelial lymphocytes into a polarized epithelial monolayer. Am. J. Physiol. 1998. 275:G584-591.
15. McCormick, BA, Siber, AM, and Maurelli, AT. Requirement of the Shigella flexneri virulence plasmid in the ability to induce trafficking of neutrophils across polarized monolayers of intestinal epithelia. Infect. Immun. 1998; 66:4237-4243.
16. Gewirtz, AT, Siber, AM, Madara, JL, and McCormick, BA. Orchestration of neutrophil movement by intestinal epithelial cells in response to Salmonella typhimurium can be uncoupled from bacterial internalization. Infect. Immun. 1999; 67: 608-617.
17. McCormick, BA, Fernandez, MI, Siber, AM, and Maurelli, AT. Inhibition of Shigella flexneri-induced transepithelial migration of polymorphonuclear leukocytes by cadaverine. Cell. Microbiol. 1999; 1:143-156.
18. Allen, JH, Utley, M, Bosch, V, Nuijten, P, Witvliet, M, McCormick, BA, Mauel, M, Krogfelt, K, Licht, TR, Brown, D, Leatham, MP, and Cohen, PS. A functional cra gene is required for Salmonella typhimurium pathogenesis in BALB/c mice. Infect. Immun. 2000; 68:3772-3775.
19. Wood, MW, Jones, MA, Watson, PR, Siber, AM, McCormick, BA, Rosqvist, R, Wallis, TS, and Galyov, EE. The secreted effector protein of Salmonella, SopA, is translocated into eucaryotic cells and influences the induction of enteritis. Cellular Microbiol. 2000; 2:293-304.
20. Cherayil, BJ, McCormick, BA, and Bosley, J. Salmonella-dependent regulation of inducible nitric oxide synthase expression in macrophages by the invasins SipB, SipC, and SipD, and the effector SopE2. Infect. Immun. 2000; 68:5567- 5574.
21. Lee, CA, Silva, M, Siber, AM, Kelly, AJ, Galyov, EE, and McCormick, BA. A secreted Salmonella protein induces a proinflammatory response in epithelial cells which promotes neutrophil migration. Proc. Natl. Acad. Sci. USA 2000; 97:12283-12288.
22. Criss, AK, Ahlgren, DM, Jou, T-S, McCormick, BA., and Casanova, JE. The GTPase Rac1 selectively regulates Salmonella invasion at the apical plasma membrane of polarized epithelial cells. J. Cell Sci. 2001; 114: 1331-1341.
23. Fernandez, I, Maurelli, AT, Silva, M, Siber, AM, Schuch, R, W. Allan Walker, and McCormick, BA. Cadaverine prevents the escape of Shigella flexneri from out of the phagolysosme: A connection between bacterial dissemination and neutrophil transepithelial signaling. J. Infect. Dis. 2001; 184: 743-753.
24. Criss, A, Silva, M, Casanova, J, and McCormick, BA. Regulation of Salmonella- induced neutrophil transmigration by epithelial ADP-ribosylation factor 6. J. Biol. Chem. 2001; 276: 48431-48439.
25. Kohler, H, Rodriques, SP, and McCormick, BA. Shigella flexneri interactions with the basolateral membrane domain of polarized model intestinal epithelium: Role of lipopolysaccharide in cell invasion and in activation of the mitogen- activated protein kinase ERK. Infect. Immun. 2002;70: 1150-1158.
26. Takanori S, Köhler, H, Gu, X, McCormick, BA and Reinecker H-C. Shigella flexneri regulates tight junction associated proteins in human intestinal epithelial cells. Cell. Microbiol. 2002; 4: 367-381.
27. Kohler H, Rodrigues, SP, Maurelli AT, and McCormick, BA. Inhibition of Salmonella typhimurium enteropathogenicity by piperidine, a metabolite of the polyamine cadaverine. J. Infect. Dis. 2002; 186:1122-1130.
28. Nadeau WJ, Pistole, TG, and McCormick, BA. Polymorphonuclear leukocyte migration across model intestinal epithelial enhances Salmonella typhimurium killing via the epithelial derived cytokine, IL-6. Microbes Infect. 2002; 4:1379-1387.
29. Hisamatsu, T., Suzuki, M., Reinecker, H-C., Nadeau, W.J., McCormick, B. A., Podolsky, D.K. Card15/Nod2 functions as an anti-bacterial factor in human intestinal epithelial cells. Gastroenterology 2003; 124:993-1000.
30. Silva, M., Song, C., Nadeau, W.J., Matthews, J.B., McCormick, B.A. Salmonella typhimurium SipA-induced neutrophil transepithelial migration: involvement of a PKC-a dependent signal transduction pathway. Am. J. Physiol. Gastrointest. Liver Physiol. 2004; 286:G1024-G1031.
31. Mrsny, R.J., Gewirtz, A.T. , Siccardi,,D., Savidge, T.C., Hurley, B.P., Madara, JL, and McCormick, B.A. Identification of hepoxilin A3 in inflammatory events: A required role in neutrophil migration across the intestinal epithelia. Proc. Natl. Acad. Sci. USA 2004; 101: 7421-7426.
32. Tenor, J.L., McCormick, B.A., Ausubel, F.M., Aballay, A. Caenorhabditis elegans-Based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions. Curr. Biol. 2004; 14:1018-1024.
33. Hurley, B.P., Siccardi, D., Mrsny, R.J., McComick, B.A. PMN transepithelial migration induced by Pseudomonas aeruginosa requires the eicosinoid hepoxilin A3. J. Immunol. 2004; 173:5712-5720.
34. Niess, J.H., Brand, S., Gu, X., Landsman, L., McCormick, B.A., Vyas, J.M., Boes, Ploegh, H.L., Fox, J.G., Littman, D.R., Reinecker, H-C. Control of dendritic cell access to the intestinal lumen and of bacterial clearance by CX3CR1. Science 2005; 307; 254-258.
35. Chen, C.C., Louie, S., McCormick, B.A., Walker, W.A., Shi, H.N. Concurrent infection of an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infect. Immun. 2005; 73: 5468-81.
36. Chen, C.C., Louie, S., McCormick, B.A., Walker, W.A., Shi, H.N. Helminth primed dendritic cells alter the host response to enteric bacterial infection. 2005 In Press: J.Immunol.
37. Hurley, B.P., Williams, N., McCormick, B.A. Involvement of phospholipase A2 in Pseudomonas aeruginosa mediated PMN transepithelial migration. 2005 In Press AJP-Lung Cellular and Molecular Physiology
38. Savidge, T.C., Newman, P.G., Pan, W-H, Weng, M.Q., Shi, H.N., McCormick, B.A., Quaroni, A., Walker, W.A. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling. In Press J. Pediatric Res.
39. Salazar-Gonzalez, R.M., Niess, J.H., Zammit, D.J., Ravindran, R., Srinivasan, A., Maxwell, J.R., Stoklasek, T., Yadav, R., Williams, I.R., Gu, X., McCormick, B.A., Pazos, M.A., Vella, A.T., Lefrancois, L., Reinecker, H-C., McSorley, S.J. CCR6-mediated dendritic cell activation of pathogen specific T cells in Peyer’s patches. In Press Immunity
Reviews:
1. McCormick BA and Zetter BR. (1992) Adhesive interactions in angiogenesis and metastasis. J. Pharmacol. Theur. 53:239-260.
2. McCormick, BA, Miller, SI, and Madara, JL. (1996) New insights on molecular pathways utilized by Salmonella species in cell binding. Frontiers in Bioscience 1: d131-145.
3. McCormick, BA, Gewirtz, AT, and Madara JL. (1998) Epithelial cross-talk with bacteria and immune cells. Current Opinion in Gastroenterology; 14; 492-497.
4. McCormick, BA. (2001) Molecular basis of Salmonella-induced enteritis. Recent Research Developments in Immunology. 4: 65-77.
5. McCormick, BA. (2003) Use of transepithelial models to examine host-pathogen interactions. Curr Opin Microbiol. 6;77-81.
6. Kohler H, McCormick BA, Walker WA. (2003) Bacterial-enterocyte crosstalk: cellular mechanisms in health and disease. J Pediatr Gastroenterol Nutr. 36;175-85.
7. Hurley, B.P. and McCormick, B.A. (2003) Translating tissue culture results into animal models: the case of Salmonella typhimurium. Trends in Microbiol. 11; 562-69.
8. Hurley, B.P. and McCormick, B.A. (2004) Intestinal epithelial defense systems protect against bacterial threats. Curr. Gastroenterol. Rep. 6; 355-361.
9. Mumy, K.L. and McCormick, B.A. (2005) Events at the host-microbial interface of the gastrointestinal tract II. Role of the intestinal epithelium in pathogen-induced inflammation. Am J Physiol Gastrointest Liver Physiol. 288; G854-G859.
Book chapters:
1. Cohen PS, McCormick BA, Franklin DP, Burghoff RL, Laux DC. The role of large intestine mucus in the colonization of the mouse large intestine by E. coli F- 18 and S. typhimurium. In, Wadstrom T, Maksela PH, Svennerholm AM, Wolf- Watz H, eds. Molecular Pathogenesis of Gastrointestinal Infections. New York and London: Plenum Press, 1991: 29-31.
2. Krogfelt KA, McCormick BA, Burghoff RL, Laux DC, Cohen PS. Expression of type 1 fimbriae in the streptomycin-treated large intestine. In, Wadstrom T, Maksela PH, Svennerholm AM, Wolf-Watz H, eds. Molecular Pathogenesis of Gastrointestinal Infections. New York and London: Plenum Press, 1991: 317- 319.
3. McCormick, BA. Salmonella: Masters of Inflammation. In, Hecht G.A., ed. Microbial Pathogens and the Intestinal Epithelial Cell. Washington, DC: ASM Press, 2003:439-454.
4. McCormick, BA. Salmonella Invasion Mechanisms. In, Lamont, R.J., ed. Bacterial Invasion of Host Cells Cambridge, U.K: Cambridge Press, 2004: 1-24.
5. McCormick, B.A. Signal Transduction in the Mucosa. In, Nataro, J.P., Cohen, P.S., Mobley, H.L., and Weiser, J.N., eds. Colonization of Mucosal Surfaces, ASM Press, 2005:265-282.
6. McCormick, B.A. Editor: Bacterial-Epithelial Cell Cross-Talk: Molecular Mechanisms in Pathogenesis (Cambridge University Press; 2006)2006)
Ph. D. Thesis:
1. McCormick, BA. The role of type-1 fimbriae, motility, and chemotaxis in the colonization of the mouse large intestine by a human fecal E. coli strain and an avirulent Salmonella typhimurium strain [Ph.D. Thesis], Kingston, Rhode Island: University of Rhode Island, 1990 256 pp.
Published Abstracts:
1. McCormick BA, Colgan SP, Miller SI, Madara JL. Apical binding of Salmonella to intestinal epithelial cells modulates neutrophil-epithelial interactions [Abstract]. Gastroenterology 1993; (Suppl); A740.
2. McCormick BA, Miller SI, Colgan SP, Madara JL. Transepithelial signaling by Salmonella typhimurium to neutrophils is associated with bacterial mediated endocytosis [Abstract]. Gastroenterology 1994; (Suppl): 104:A731.
3. McCormick, BA, Parkos, CA, Colgan, SP, Carnes, DA, and Madara, JL. Surface attachment of Salmonella typhimurium to intestinal epithelia elicits the secretion of a novel neutrophil chemoattractant [Abstract]. Keystone Symposia on The Role of Chemokines in Leukocyte Trafficking and Disease 1997; pg. 11.
4. Shibahara T, Shaw SK, Hermanowski-Vosatka A, McCormick, BA., and Madara J.L. Efficient homing of intraepithelial-derived lymphocytes (IEL) back to the intercellular spaces of model- polarized intestinal epithelia. [Abstract]. Gastroenterology 1998; (Suppl): 114: A1083.
5. Gewirtz AT, Siber AM, Madara JL, and McCormick, BA. Specific apical intestinal epithelial-S typhimurium interactions disociable from bacterial invasion mediate epithelial orchestration of neutrophil movement [Abstract]. Gastroenterology 1999; (Suppl): 116: A773.
6. Chaturvedi P, McCormick, BA., Warren, CD., Siber, AM., and Newburg, DS. Human milk sulfated glycolipids inhibit Salmonella typhimurium pathogenesis in vitro. [Abstract] Glycobiology 1998; 8:155.
7. Lee CA, Silva M, Kelly AJ, and McCormick, B.A. Intestinal epithelial orchestration of neutrophil movement in response to S. typhimurium (S.t.) is mediated by a S.t. secreted protein, SipA [Abstract]. Gastroenterology 2000; (Suppl): 118: A695.
8. Kohler, H, Rodrigues, S, Maurelli, AT, Cario, E, Podolsky, DK, and McCormick, BA. Invasion of Shigella flexneri into model human intestinal epithelia is dependent on a lipopolysaccharide interaction with the host cell. [Abstract]. Gastroenterology 2001; (Suppl); 120: A371.
9. Sakaguchi, T, Köhler, H, Xuibin, G, McCormick, BA, and Reinecker, H-C. Mechanistic repertoire of Shigella flexneri to regulate tight junctional complexes in human intestinal epithelial cells. [Abstract] Gastroentrology 2001; (Suppl): 120: A767.
10. Kohler, H., Sakagushi, T, Kase, BJ, Reinecker, H-C, and McCormick, BA. Salmonella typhimurium regulates epithelial tight junctions: the effects on polymorphonuclear leukocyte movement across model intestinal epithelium Abstract]. Gastroenterology. 2002; (Suppl) 122: A125.
11. Kohler, H., Rodrigues, SP, and McCormick, BA. Piperidine, a metabolite of the intestinal microflora, adversely influences Salmonella typhimurium enteropathogenicity [Abstract]. Gastroenterology 2002; (Suppl) 122: A141.
12. Muzumdar, H.V., Wang, M-Y, McCormick, BA, Saban, MR, Saban, R, and Wershil, B.K. Critical role of tumor-necrosis factor-alpha in host defense against Salmonella typhimurium [Abstract]. Gastroenterology 2003; (Suppl) 122: A734.
Patents
Application serial number: PCT/US02/35039 - Salmonella Virulence Factors and Uses Thereof (Co-Inventor)
Application serial number: 60/480, 982 – Compositions Comprising Pathogen Elicited Epithelial Chemoattractant (Eicosanoid Hepoxilin A3), Inhibitors Thereof and Methods of Use Thereof (Inventor).
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