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OverviewThe Neurological Clinical Research Institute (NCRI) was co-founded in 1994 by Dr. Merit Cudkowicz and Dr. Steven Greenberg to conduct clinical research in neurological disorders. The NCRI develops, designs, supports and manages innovative observational and interventional trials for neurological disorders. In collaboration with the Study Monitoring and Outcome Measures Center at SUNY Upstate Medical Center and the Mass General Biostatistics Center, the NCRI has an impressive record of rapidly and efficiently organizing, overseeing, coordinating, and conducting small and large multi-center, international clinical trials including randomized, double-blind, double-dummy and open label designs.
The mission of the NCRI is to accelerate translational research in neurological disorders through initiating and testing novel therapies. The NCRI will fulfill this mission by supporting the entire therapeutic development process, including:· Mapping the clinical development of potential therapies;· Custom design of clinical research protocols; · Bringing efficiency strategies and infrastructure to clinical research;· Providing resources, experienced staff, and services to accelerate the conduct of clinical research;· Fostering and empowering scientific collaboration;· Creating partnerships among scientific leaders with complementary backgrounds;· Establishing and managing disease-specific research consortia;· Performing high quality site-level clinical research;· Educating and mentoring future leaders in the field of clinical research; and· Encouraging scientific innovation through funding.
Northeast ALS Consortium (NEALS)
The NCRI serves as a Coordinating Center for the Northeast ALS Consortium (NEALS), a non-profit, research consortium committed to the cooperative implementation, timely completion, analysis, and reporting of clinical trials and other research studies aimed at improving patient care and understanding of the disease process of Amyotrophic Lateral Sclerosis (ALS). Together, the two entities have supported/conducted 19 clinical research studies in ALS.
Dr. Merit Cudkowicz co-founded and co-directs the NEALS Consortium. The NEALS Consortium was formed with the goal of bringing together leading ALS scientists and clinicians caring for ALS patients, to offer advice on the selection of the best therapies and direction of ALS research. Today there are 103 medical sites and more than 400 members across North America.
Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT)The NCRI serves as the Clinical Coordinating Center for the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT), an National Institute of Neurological Disorders and Stroke (NINDS) initiative which provides a robust, standardized, and accessible infrastructure to facilitate rapid development and implementation of protocols in neurological disorders affecting adult and/or pediatric populations. Today there are 25 sites nationally.
The Mass General Neurological Clinical Research Institute has over 60 staff members dedicated to neurology clinical research.
Merit Cudkowicz, MD, MScNCRI Co-DirectorMassachusetts General Hospital617firstname.lastname@example.org
Steve Greenberg, MD, PhDNCRI Co-DirectorMassachusetts General Hospitalsgreenberg@partners.org
Nazem Atassi, MDMassachusetts General Hospital617-643-6114 email@example.com
James Berry, MDMassachusetts General Hospital firstname.lastname@example.org
Anne-Marie Wills, MDMassachusetts General Hospital617email@example.com
Patricia Andres, DPT, MS, PTMassachusetts General Hospital617firstname.lastname@example.org
Marianne Kearney ChaseDirector of Project Management617-726-5893mkearney4@Partners.org
Janice O'BrienOffice/Program Manager email@example.com
Darlene Sawicki, NPCo-Director of MGH ALS Multidisciplinary Clinic617firstname.lastname@example.org
Alex ShermanDirector of Systems617email@example.com
Hong Yu, MPHDirector of Data Management617firstname.lastname@example.org
Our Work in ALS
Our staff is dedicated to finding new treatments for ALS. Our team leads and manages clinical trials at major medical institutions throughout the United States and Canada. The Mass General NCRI can also give interested individuals with ALS access to participate in clinical trials of medications and therapies designed to lead to better treatments. Below is a list of our active trials in ALS.
Active Trials in ALS
ALS/Lou Gehrig's Disease: A Pilot Study of Inosine in ALSALS/Lou Gehrig's Disease: AIMALS/Lou Gehrig's Disease: EAT MOREALS/Lou Gehrig's Disease: Natural History of C9ORF72 ALS/Lou Gehrig's Disease: Neuroinflammation in ALS ALS/Lou Gehrig's Disease: Skin Biopsy ALS/Lou Gehrig's Disease: Trial of Resistance and Endurance Exercise in ALS ALS: EIM
Other WorkThe NCRI also serves as coordinating center for studies initiated by members of the Mass. General Neurology Department. It is the Data Management core for all NIH-funded MGH SPOTRIAS projects (Dr. Karen Furie, PI) as well as for a Parkinson’s disease biomarker study (Dr. Scherzer, PI). The MGH NCRI provides expertise in IND submissions and reporting, trial execution and feasibility and efficiency for various disease populations inclusive of studies in ALS, Multiple Sclerosis, Non-Arteritic Anterior Ischemic Optic Neuropathy, Progressive Supranuclear Palsy, Myasthenia Gravis, and Adrenoleukodystrophy.
Neurological Clinical Research Institute (NCRI)
165 Cambridge Street
E-mail Dr. Cudkowicz:email@example.com
Neurological Clinical Research Institute Mailcode: CNY B149-2-2274Massachusetts General Hospital149 13th Street, 2nd Floor, Room 2274Charlestown, MA 02129
Clinical Research Staff
Marianne Kearney ChaseClinical Research Program/Project ManagerPhone: 617-726-5893E-mail:MKearney4@Partners.org
Janice O’BrienOffice/Program Manager 617-643-2478
Patient Appointments & Clinical Office
ALS Multidisciplinary ClinicPhone: 617-724-3914
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