My research is focused on kidney development and regeneration.

Aleksandr Vasilyev, MD, PhD 
Instructor of Pathology
149 13th Street
Charlestown, MA 02129
Phone: (617) 643-2872
Fax: (617) 726-5669
Email: avasilyev@partners.org

 

Dr. Vasilyev's work is focused on kidney development and regeneration.

1) He recently discovered that zebrafish kidney epithelial cells migrate towards the glomerulus is response to luminal fluid flow. This collective cell migration leads to profound morphological changes including proximal tubule convolution and repositioning of nephron segments. His current efforts are focused on trying to uncover the molecular mechanisms underlying this novel form of collective cell migration. 

2) He developed a novel assay of acute kidney injury in zebrafish using segmental photoablation of kidney tubular epithelia. He is utilizing this assay to study the relative role of cell migration, cell proliferation and cell metaplasia in acute injury and repair.

 

References:

  1. Mangos S, Lam PY, Zhao A, Liu Y, Mudumana S, Vasilyev A, Liu A, and Drummond IA. The ADPKD genes pkd1a/band pkd2 regulate extracellular matrix formation. Dis Model Mech. 24 March, 2010.
  2. Vasilyev A and Drummond IA. Fluid flow and guidance of collective cell migration. Cell Adh Migr. 2010. 4(3).
  3. Vasilyev A, Liu Y, Mudumana S, Mangos S, Lam PY, Majumdar A, Zhao J, Poon KL, Kondrychyn I, Korzh V, and Drummond IA. Collective cell migration drives morphogenesis of the kidney nephron. PLoS Biol. 2009. 7(1): e9.
  4. Mudumana SP, Hentschel D, Liu Y, Vasilyev A, and Drummond IA. Odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate. Development. 2008. 135(20): 3355-67.