My research focuses on vitamin D and the immune system in humans, particularly in the setting of renal disease.

Ishir Bhan, MD, MPH
Instructor of Medicine 
50 Staniford Street, Suite 771C
Boston, MA 02114
Phone: (617) 726-3934
Fax: (617) 726-5669
Email: ibhan@partners.org

 

My research focuses on vitamin D and the immune system in humans, particularly in the setting of renal disease. We are performing both observational studies and interventions aimed at identifying the effects of vitamin D on various aspects of the inflammatory cascade as well as clinical outcomes. Recent work focuses on the human antimicrobial peptide hCAP18, a key of the innate immune defense. Future work will identify additional mediators of immunity influenced by vitamin D and assess the importance of these factors in clinically-relevant endpoints.

 

References:

  1. Gombart AF, Bhan I, Borregaard N, Cmaargo CA Jr, Koeffler HP, and Thadhani RI. Low plasma cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in hemodialysis. Clin Infect Dis. 2009; 48: 418-424.
  2. Bhan I and Thadhani RI. Vitamin D Therapy for Chronic Kidney Disease. Semin Nephrol. 2009. 29: 85-93. 
  3. Bhan I, Tamez H, and Thadhani RI. Role of Vitamin D and Vitamin D Analogues for Bone Health and Survical in Chronic Kidney Disease. In Holick MF, ed. Vitamin D: Physiology, Molecular Biology and Clinical Applications, 2nd Ed. Towata, NJ: Humana Press. 2009. In press
  4. Gutierrez OM, Tamez H, Bhan I, Zazra J, Tonelli M, Wolf M, Januzzi JL, Chang Y, Thadhani RI. N-terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) Concentrations in Hemodialysis Patients: Prognostic Value of Baseline and Follow-up Measurements. Clin Chem. 2008. 1339-48.