My research focuses on the biological actions of vitamin D. Particular areas of interest include the effects of vitamin D on the immune system, the role of vitamin D binding protein, and the effects of chronic kidney disease on vitamin D biology. I have been involved in several clinical trials as a principal investigator, co-investigator, medical monitor, and data and safety monitoring board member.

In my role as Director of Nephrology Informatics, I develop and oversee execution of new departmental IT projects aimed at facilitating clinical practice, education, and research, for example providing support for research grants requiring analysis of large datasets and other IT resources.

References

  1. Bhan I and Thadhani RI.Vitamin D Therapy for Chronic Kidney Disease. Semin Nephrol. 2009; 29: 85-93. 
  2. Bhan I, Burnett-Bowie SA, Ye J, Tonelli M, Thadhani R. Clinical measures identify vitamin D deficiency in dialysis. Clin J Am Soc Nephrol. 2010; 5(3): 460-7.
  3. Bhan I, Camargo CA Jr, Wenger J, Ricciardi C, Ye J, Borregaard N, Thadhani R. Circulating levels of 25-hydroxyvitamin D and human cathelicidin in healthy adults. J Allergy Clin Immunol. 2011; 127(5):1302-4.
  4. Powe CE, Ricciardi C, Berg AH, Erdenesanaa D, Collerone G, Ankers E, Wenger J, Karumanchi SA, Thadhani R, Bhan I. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011; 26(7):1609-16.
  5. Bhan I, Powe CE, Berg AH, Ankers E, Wenger JB, Karumanchi SA, Thadhani RI. Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients. Kidney Int. 2012; 82(1):84-9.
  6. Nigwekar SU, Wenger J, Thadhani R, Bhan I. Hyponatremia, mineral metabolism, and mortality in incident maintenance hemodialysis patients: a cohort study. Am J Kidney Dis. 2013; 62(4):755-62.
  7. Allegretti AS, Steele DJ, David-Kasdan JA, Bajwa E, Niles JL, Bhan I. Continuous renal replacement therapy outcomes in acute kidney injury and end-stage renal disease: a cohort study. Crit Care. 2013; 17(3):R109.
  8. Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nalls M, Tamez H, Zhang D, Bhan I, Karumanchi SA, Powe NR, Thadhani R. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med. 2013; 369(21):1991-2000.
  9. Corapi KM, McMahon GM, Wenger JB, Seifter JL, Bhan I. Association of loop diuretic use with higher parathyroid hormone levels in patients with normal renal function. JAMA Intern Med. 2015; 175(1):137-8.
  10. Bhan I, Dobens D, Tamez H, Deferio JJ, Li YC, Warren HS, Ankers E, Wenger J, Tucker JK, Trottier C, Pathan F, Kalim S, Nigwekar SU, Thadhani R. Nutritional vitamin D supplementation in dialysis: a randomized trial. Clin J Am Soc Nephrol. 2015; 10(4):611-9.
  11. Quraishi SA, De Pascale G, Needleman JS, Nakazawa H, Kaneki M, Bajwa EK, Camargo CA Jr, Bhan I. Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis: A Randomized, Placebo-Controlled Trial. Crit Care Med. 2015; 43(9):1928-37.

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