My laboratory studies the genetic basis of chronic allograft nephropathy.

Winfred Williams, MD 
Assistant Professor of Medicine 
185 Cambridge Street, CPZN 6.808
Boston, MA 02114
Phone: (617) 643-3289
Fax: (617) 724-1122
Email: wwwilliams@partners.org

Dr. Williams studies the genetic basis of chronic allograft nephropathy as an Associate Member of the Broad Institute. Human genome sequencing revealed that the entire autosomal genes may deleted, with some of these gene-deletion alleles being sufficiently common. Because the immune system of an individual with a homozygous gene deletion may not be tolerant to a "foreign" antigen from a donor, such genomic variations may contribute to risk of chronic rejection and alloimmune disease. Studies are being conducted to determine whether donor-recipient mismatch for homozygous gene deletions increases the risk of kidney rejection after transplantation.