My research focuses on the transcriptional regulation of blood cell development. We especially are interested in the identification of key transcription factors in hematopoietic stem cell (HSC) and progenitor cell development. Particular emphasis is on the role of ZBP-89, SCL, Dusp22 as well as integrins in HSC development. We are currently utilizing multidisciplinary approaches to understand how these transcription factors regulate HSC fate determination. These methods include zebrafish, murine embryonic stem cell and mouse models as well as biochemical assays.


  1. Li X, Vradii D, Gutierrez S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Javed A. Subnuclear Targeting of Runx1 is required for Synergistic Activation of the Myeloid pecific M-CSF Receptor Promoter by PU.1. J Cell Biochem 2005; 96(4):795-809
  2. Li X, Xiong JW, Shelley CS, Park H, Arnaout MA. The transcription factor ZBP-89 controls Generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells. Development. 2006; 133(18):3641-50
  3. Dowdy CR, Xie R, Frederick D, Hussain S, Zaidi SK, Vradii D, Javed A, Li X, Jones SN, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation. Hum Mol Genet. 2010; 19(6):1048-57
  4. Li X, Romain RD, Park D, Scadden DT, Merchant JL, Arnaout MA. Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89. Stem Cells 2014; 32(3):791-801

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