My research focuses on the transcriptional regulation of blood cell development.

Xiangen Li, MD, PhD 
Instructor of Medicine 
149 13th Street
Charlestown, MA 02129
Phone: (617) 726-5642
Fax: (617) 726-5669
Email: Xli9@partners.org

 

My research focuses on the transcriptional regulation of blood cell development. We especially are interested in identification of transcription factor in hematopoietic stem cell (HSC) and progenitor cell development. Particular emphasis is on the role of ZBP-89, SCL and other transcription factor in HSC development. We are currently utilizing multidisciplinary approaches to understand how these transcription factors regulate HSC fate determination. These methods include zebrafish, murine embryonic stem cell and mice models as well as biochemical assays.

 

References:

  1. Li X, Vradii D, Gutierrez S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, and Javed A. Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-C SF receptor promoter by PU.1. J Cell Biochem. 2005. 96(4): 795-809.
  2. Li X, Xiong JW, Shelley CS, Park H, and Arnaout MA. The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells. Development. 2006. 133(18): 3641-50.
  3. Li X, Shelley CS, and Arnaout MA. Differential Role of the transcription factor ZBP-89 in Hemangioblast Fate Determination: ZBP-89 is a Direct Regulator of SCL. Blood (ASH Annual Meeting Abstracts). Nov 2007. 110: 1253.
  4. Dowdy CR, Xie RL, Frederick D, Hussain S, Zaidi SK, Vradii D, Javed A, Li X, Jones SN, Lian JB, Vanwijnen AJ, Stein JL, and Stein GS. Definitive Hematopoiesis Requires Runx1 C- Terminal - Mediated Subnuclear Targeting and Transactivation. Human Molecular Genetics. (submitted)