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For the past three years newlyweds, Peter Mundel, MD, and Anna Greka, MD, PhD, both of the Division of Nephrology in the MGH Department of Medicine, have been working with other MGH colleagues on what may be the first targeted treatment for kidney diseases.
A group of MGH investigators has identified a molecule that plays a key role in the breakdown of the kidney filter, presenting a potential therapeutic target for stopping the type of kidney damage associated with diabetes before it becomes irreversible.
A drug approved for the treatment of rheumatoid arthritis may also turn out to be the first targeted therapy for one of the most common forms of kidney disease, a condition that almost inevitably leads to kidney failure.
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