Researchers at the MGH Renal Unit describe five families with mutations in the TRPC6 ion channel

27/May/2005

Researchers at the Division of Nephrology described five families with mutations in the TRPC6 ion channel associated with focal segmental glomerulosclerosis, a disease characterized by progressive kidney failure. They further show that TRPC6 interacts with podocin and nephrin, two components of the glomerular slit diaphragm previously  implicated in proteinuric kidney disease (Reiser et al. 2005 Nature Genetics, Published online: 27 May 2005; | doi:10.1038/ng1592)