The Division of Nephrology's research programs are directed towards the elucidation of basic cellular mechanisms and the causes, management and potential therapies of kidney disease. Major research activities are carried out by investigators in sixteen basic research laboratories. Cell biological, molecular biological, biophysical, structural and genetic methodologies are used to understand specific aspects of epithelial, endothelial and leukocyte functions, membrane protein organization, membrane transport, organogenesis, cell adhesion and migration and cell growth and differentiation.
A major new basic research effort based in the Division of Nephrology is the Mass General Structural Biology Program aimed at determining the three-dimensional structure of molecules, in order to gain more insight into their function with the potential of developing antagonists that could be used therapeutically. A crystallography facility equipped with a state-of-the-art automated X-ray Imaging System (R-AXIS IV), X-ray Generator, Silicon Graphics computers and protein modeling software is staffed by three crystallographers and has been in full operation since March 1, 1998.
Active clinical and translational research programs in hypertension, preeclampsia, transplantation, dialysis and outcomes research complement and extend the basic science programs of the Division of Nephrology.
Ongoing Projects Stratisfy into the Following Themes:
Molecular Basis of Water, Acid, and Solute Transport (Investigators: Ausiello, Breton, Brown, Cantiello, Ercolani, Marshansky, Sever, van Hoek)
Renal Injury and Repair (Investigators: Adair, Arnaout, Christmas, Greka, Soberman, Lin)
Developmental Biology and Genetics (Investigators: Arnaout, Drummond, JW Xiong)
Glomerular Diseases (Investigators: Arnaout, Drummond, Greka, Sever, Thadhani)
Clinical Epidemiology (Investigators: Bhan, Thadhani, Wong)
Vascular Biology and Hypertension (Investigators: Arnaout, Haupert, Kang, JW Xiong)
Inflammation, Autoimmunity and Transplantation Biology (Investigators: Adair, Arnaout, Goes, Niles, Tolkoff-Rubin, Sachs, JP Xiong)
Genomics, Proteomics applied to diabetes mellitus and cancer (Investigators: Arnaout, Greka, Thadhani)
Receptor Dynamics (Investigators: Adair, Arnaout, JP Xiong)
Medical Informatics (Investigators: Bhan)
Specific Projects Include: