The Neuroendocrine and Pituitary Tumor Clinical Center

Established in 1985, the Mass General Neuroendocrine and Pituitary Tumor Clinical Center provides an integrated approach to patients with pituitary and hypothalamic disorders. Working in partnership, endocrinologists, neurosurgeons, radiation oncologists, and neurologists at Massachusetts General Hospital as well as neuroophthalmologists at the adjacent Massachusetts Eye and Infirmary, provide a depth of expertise that has transformed us into a major international and national referral center for patients with pituitary and hypothalmic disorders.

Committed to Patient Care

Although the Neuroendocrine Unit is rooted in scientific advancement, our team of more than 20 clinicians is deeply committed to day-to-day patient care. Our physicians evaluate and manage patients through the Neuroendocrine and Pituitary Tumor Clinical Center, a multidisciplinary care center made up of expert endocrinologists, neurosurgeons, neurologists, radiation oncologists, and nurses. Our specialists diagnose and manage the full range of neuroendocrine conditions, including:

Pituitary Tumors

  • Prolactinomas
  • Cushing's disease
  • Acromegaly
  • Non-functioning tumors
  • Recurrent pituitary adenomas
  • Thyrotroph adenomas

Prolactin Disorders

  • Amenorrhea-Galactorrhea Syndrome
  • Drug-induced hyperprolactinemia
  • Infertility
  • Male hypogonadism

Cushing's Disease

  • Pituitary Cushing's
  • Ectopic Cushing's
  • Adrenal Cushing's
  • Iatrogenic Cushing's
  • Recurrent Cushing's


  • Hypoadrenalism
  • Hypogonadism
  • Hypothyroidism (central)
  • Growth hormone deficiency

Posterior Pituitary Dysfunction

  • Diabetes insipidus
  • Syndrome of inappropriate antidiuretic hormone secretion

Hormone Dependent Neurologic Disorders

  • Headaches

Sellar Masses

  • Meningiomas
  • Craniopharyngiomas
  • Hypophysitis and other inflammatory disorders
  • CNS Sarcoid
  • Germinomas
  • Other sellar lesions

Our Research

Our goal is to learn and create novel treatments that will help improve clinical care for patients with neuroendocrine disorders and neuroendocrine malignancies. Research at the Neuroendocrine and Pituitary Tumor Clinical Center at Mass General is divided into four major research areas including:

  1. Pathogenesis and regulation of human pituitary adenomas
  2. Pathophysiology of neuroendocrine disorders
  3. Relationship between nutritional disorders and neuroendocrine factors
  4. Development of novel therapies for patients with pituitary and hypothalamic disorders

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