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| Publications |
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Steven Reeves, PhD, Director of the CNS SIGNALING LABORATORY
Dr. Reeves' research program focuses on the molecular mechanisms of signal transduction in neuronal and glial cell types. The CNS Lab uses a number of biochemical and molecular techniques, pharmacological inhibitors and mouse models to characterize survival/death/differentiation signaling pathways important in the nervous system and which are activated by cytokines such as ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF). email: sreeves@partners.org
Dirk Reinhold, PhD (Postdoctoral Fellow)
Dr. Reinhold currently holds a Medical Faculty position at the Otto von Guericke University Magdeburg and runs his own lab in the Institute of Immunology.
Daniel Oberer, (Undergraduate Student)
Daniel is currently completing an MD program at the Medical School at The Johns Hopkins University.
Werner Paulus, MD (Postdoctoral Fellow)
Dr. Paulus currently is a full professor at the University of Munster, Germany, where he is Director of the Institute for Neuropathology. email: werner.paulus@uni-muenster.de
Maxwell Heiman, (Undergraduate Student)
Maxwell is currently completing an MD/PhD program at the University of California San Francisco. email: heiman@socrates.ucsf.edu
Holger Willenbring, (Medical Student)
Holger is currently completing an MD/PhD program at the Oregon Health & Science University in Portland. email: willenbring@ohsu.edu
Tiziana Servidei, PhD (Postdoctoral Fellow)
Dr. Servidei currently holds a a faculty position in the Division of Pediatric Oncology, Catholic University, Italy. email: servidei@tin.it
Yoko Aoki, MD/PhD (Postdoctoral Fellow)
Dr. Aoki currently holds a Clinical research faculty position in the Department of Medical Genetics at Tohoku University School of Medicine, Japan. email: aokiy@mail.tains.tohoku.ac.jp
Hirofumi Hiyama, MD (Postdoctoral /Medical Fellow)
Dr. Hiyama currently holds a Clinical research faculty position in the Department of Neurosurgery, Neurological Institute, Tokyo Women’s Medical University. email: hhiyama@nij.twmc.ac.jp
Kiyotaka Yokogami, MD (Postdoctoral /Medical Fellow)
Dr. Yokogami currently holds a Clinical research faculty position in the Department of Neurosurgery at Miyazaki Medical College, Japan. email: akatoyik@post.miyazaki-med.ac.jp
Kamal Jilani (Postdoctoral /Medical Fellow)
Shigeru Tani, MD (Postdoctoral /Medical Fellow). Dr. Tani currently holds a Clinical research faculty position in the Section of Neurosurgery, Saitama-ken Saiseikai Kurihashi Hospital. Japan. email: stani@nij.twmu.ac.jp
Sean Lawler, PhD (Instructor)
Dr. Lawler holds a Research faculty position and runs his own laboratory in the Department of Neurosurgery at Ohio State University, Columbus.
Tong Lin, MD, PhD (Postdoctoral /Medical Fellow)
email: tlin6@partners.org
Zhongmin Xiang, MD, PhD
email: zxiang1@partners.org
1) Reeves SA, Helman LJ, Allison A, Israel MA. Molecular cloning and primary structure of human glial fibrillary acidic protein. PNAS USA 86:5178-5182, 1989.
2) Reeves SA, Chavez-Kappell C, Rosenblum M, Israel MA. The tyrosine-kinase substrate Annexin 2 is expressed in high grade glioma and early human central nervous system development. Cancer Res 52:1-6, 1992.
3) Reeves SA, Yamanaka M. Cloning and sequence analysis of the alpha subunit of the cat flea sodium pump. Insect Biochem Mol Biol 7:809-814, 1993.
4) Shum L, Reeves SA, Kuo AC, Fromer ES, Derynck R. Association of the transmembrane TGF-α precursor with a protein kinase complex. JBC 125:903-916, 1994.
5) Reeves SA, Rubio M-P, Louis, DN. A general method for PCR amplification and direct sequencing of mRNA differential display products. Biotechniques 18:18-20, 1995.
6) DiFiglia M, Sapp E, Chase K, Schwarz C, Meloni A, Young C, Martin E, Vonsattel J-P, Carraway R, Reeves SA, Boyce FM, Aronin N. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 14:1075-1081, 1995.
7) Yong WH, Ueki K, Chou D, Reeves SA, von Deimling A, Gusella JF, Mohrenweiser HW, Buckler AJ, glioma candidate region on chromosome 19q13.3. Genomics 29:533-536, 1995.
8) Reeves SA, Reinhold D, Baur I, Sinha B, Harsh GR. An alternative role for the src-homology-domain-containing phosphotyrosine phosphatase (SH-PTP2) in regulating epidermal-growth-factor-dependent cell growth. Eur J Biochem, 233:55-61, 1995.
9) Paulus W, Baur I, Boyce FM, Breakefield XO, Reeves SA. Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells. J Virol, 70:62-67, 1996.
10) Paulus W, Lisle DK, Tonn JC, Wolf HK, Roggendorf W, Reeves SA, Louis DN. Molecular genetic alterations in pleomorphic xanthoastrocytoma. Acta Neuropathol, 91:293-297, 1996.
11) Reeves SA, Ueki K, Sinha B, DiFiglia M, Louis DN. Regional expression and subcellular localization of the tyrosine-specific phosphatase SH-PTP2 in the adult human nervous system. Neuroscience, 71:1037-1042, 1996.
12) Yu JS, Sena-Esteves M, Paulus W, Breakefield XO, Reeves SA. Drug-regulated apoptotic death in a rat glioma model mediated by a novel retroviral vector. Cancer Res, 56:5423-5427, 1996.
13) Paulus W, Baur I, Reeves SA. Diffuse brain invasion of glioma cells requires Beta 1-Integrins. Lab Invest, 75(6):819-826, 1996.
14) Paulus W, Baur I, Breakefield XO, Reeves SA. Regulated expression of the diphtheria toxin A gene in human tumor cells using prokaryotic transcription control elements. J Neurosurg, 87:89-95,1997.
15) Hirofumi H, Iavaroni A, Labaer J, Reeves SA. Transcriptional activation of the cdk inhibitor p21 gene by ectopic cyclin D1 expression does not alter cell cycle progression but can contribute to transformation. Oncogene, 14:2533-2542, 1997.
16) Symes A, Stahl N, Reeves SA, Farruggella T, Servidei T, Gearan T, Yancoupoulos G, Fink JS. The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression. Curr Biol, 7:697-700,1997.
17) Servidei T, Bhide PG, Huang Z, Moskowitz MA, Harsh G, Reeves SA. The protein-tyrosine phosphatase SHP-2 is expressed in glial and neuronal progenitor cells, postmitotic neurons and reactive astrocytes. Neuroscience, 82:529-543, 1998.
18) Hirofumi H, Iavaroni A, Reeves SA. Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F. Oncogene, 16:1513-1523, 1998.
19) Servidei T, Aoki Y, Lewis SE, Symes A, Fink JS, Reeves SA. Coordinate regulation of STAT signaling and c-fos expression by the tyrosine phosphatase SHP-2. JBC, 273:6233-6241, 1998.
20) Hirofumi H, Reeves SA. Role for cyclin D1 in UVC-induced and p53-mediated apoptosis. Cell Death & Diff, 6:565-569, 1999.
21) Sonntag KC, Haller G, Giauffret D, Germana S, Reeves SA, Sachs DH, LeGuern C. Regulated expression of an MHC class II gene from a promoter-inducible retrovirus, Hu Gene Ther, 11:1961-1969, 2000.
22) Herrlinger U, Pechan PA, Jacobs AH, Woiciechowski C, Rainov NG, Fraefel C, Paulus W, Reeves SA. HSV-1 infected cell proteins influence tetracycline-regulated transgene expression, J Gene Med, 2:379-389, 2000.
23) Yokogami K, Wakisaka S, Avruch J, Reeves SA. Serine phosphorylation of STAT during CNTF signaling is mediated by the mammalian target of rapamycin, mTOR, Curr Biol, 10:47-50, 2000.
24) Aoki Y, Huang Z, Bhide PG, Huang I, Moskowitz MA, Reeves SA. Increased Susceptibility to Ischemia-Induced Brain Damage in Transgenic Mice Overexpressing a Dominant Negative Form of SHP2. FASEB J, 14: 1965-1973, 2000.
25) Mitsuhashi T, Aoki Y, Eksioglu YZ, Takahashi T, Bhide PG, Caviness Jr VS, Reeves SA. Overexpression of p27Kip1 lengthens G1-phase in a mouse model that targets inducible gene expression to CNS progenitor cells. PNAS, 98: 6435-6440, 2001.
26) Jiao J, Kaur N, Lu B, Reeves S, Halvorsen SW. Initiation and maintenance of CNTF-Jak/STAT responses in neurons is blocked by protein tyrosine phosphatase inhibitors, Brain Res Mol Brain Res, 19:135-146, 2003.
27) Canzoniere D, Farioli-Vecchioli S, Conti F, Tata AM, Ciotti MT, Lakshmana MK, Mattei E, Krizhanovsky V, Ben-Arie N, Reeves SA, Giovannoni R, Servadio A, Tirone F. Dual control of neurogenesis through cell cycle inhibition and induction of Math1 by the gene PC3. J Neuro Sci 31:3355-69, 2004.
BOOKS/CHAPTERS
1. Reeves SA. LLR and direct sequencing of mRNA differential display products. in Fingerprinting Methods Based on Arbitrarily Primed PCR (ed. Micheli MR, Bova R) Springer-Verlag, New York NY, 1997.
2. Reeves SA. Retrovirus Vectors and Regulatable Promoters. in Gene Therapy for Neurologic Disorders and Brain Tumors (ed. Chiocca AE, Breakefield XO) The Humana Press Inc., Totowa NJ, 1997.
3. Reeves SA, Rubio M-P, Louis, DN. A general method for PCR amplification and direct sequencing of mRNA differential display products. in Expression Genetics: Differential Display (ed. Pardee A, McClelland M) Eaton Publishing Co., Natick MA, 1999.