Physician Photo

Florence Lai, MD

MGH Patients please call: 617-726-2664 Down Syndrome Patients who see Dr. Lai at Mclean Hospital should call: 617-855-2354

  • Phone: 617-726-2664
Department of Neurology
Department of Pediatrics


  • MassGeneral Hospital for Children
  • Neurology
  • Learning Disorders
Clinical Interests
Learning disabilities
Attention deficit disorder
Alzheimer's disease in down syndrome
Belmont: McLean Hospital
Boston: Massachusetts General Hospital
Medical Education
MD, University of Pennsylvania School of Medicine
Residency, Boston Medical Center
Residency, Bronx Municipal Hospital Center
Board Certifications
Neurology with Special Qualifications in Child Neurology, American Board of Pediatrics
Pediatrics, American Board of Pediatrics
Patient Gateway
Yes, learn more
Foreign Languages
Patient Age Group
Accepting New Patients
Accepting New Patients

Research1984-1989. NICHD. Optimizing selective attention in mental retardation: project 6 "Functional decline in Down sydrome individuals over age 40 in a longitudinal study".  Clinical collaborator. Marcel Kinsbourne, P.I.

1992-1993. Alzheimer's Association/Thomas . Klutznick Co. pilot research grant."Neurologic and neuropsychologic evaluations in pre-demented Down syndrome individuals".  Principal investigator.

1995-1994. NIA. Pilot PI for " Down syndrome pilot studies: Alzheimer's disease diagnosis in Down syndrome."
LEAD Award "Proteolysis in Alzheimer's disease pathogenesis.  RA Nixon, PI

1998-2003. Consultant for NIA study, "Epidemiology of menopause and dementia in Down syndrome" N. Schupf, PI

1999-2010.  Site PI for NIA/NICHD/National Institute of Complementary and Alternative Medicine study "A mutlicenter Vitamin E Trial in aging persons with Down syndrome"  Project directors: AJ Dalton, PS Aisen, MC Sano

PublicationsLai F, Williams RS.  A prospective study of Alzheimer disease in Down syndrome. Arch Neurol 1989;46(8):849-853.

Lai F
Clinicopathologic features of Alzheimer disease in Down syndrome.  Progress in Clinical Biological Research 1992; 379:15-34.

Hyman BT, West HL, Rebeck GW, Lai F, Mann DMA.  Neuropathological changes in Down syndrome hippocampal formation: effect of age and apolipoprotein E genotype. Arch Neurol 1995; 52:373-378.

Alyward EH, Burt DB, Thorpe LU, Lai F, Dalton AJ. Diagnosis of dementia in individuals with intellectual disability. J Intellect Disab Res 1997; 41:152-164.

Lai F, Kammann E, Rebeck GW, Anderson AJ, Chen Y, Nixon RA.  ApoE and gender effects on Alzheimer disease in 100 adults with Down syndrome.  Neurology 1999; 53:331-336.

Schupf N, Pang D, Patel, SLiverman, Schubert R, Lai F, Kline Jk, Stern Y, Ferin M, Tycko B, Maeux R.  Onset of dementia is associated with age at menopause in women with Down syndrome. Annals of Neurology 2003; 54:433-438.

Sano M, Aisen PS, Dalton AJ, Andrews HF, Tsai WY (Lai F as part of the International Down Syndrome and Alzheimer's Disease Consortium). Assessment of aging individuals with Down syndrome in clinical trials: results of baseline measures.  J Policy Practice in Intell Disabiliteis 2005:126-138.

Wegiel J, Kaczmarski W, Barua M et al (including Lai F). Link between KYRK1A overexpression and several-fold endhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome.  J. Neuropathol Exp Neurol 2011;70:36-50.

Pediatric Neurology
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-2664
Fax: 617-724-7860

McLean Hospital
115 Mill Street
Belmont, MA 02478-9106

Phone: 617-855-2354
Fax: 617-855-3731