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Raymond J. Kelleher, III, MD, PhD

  • Phone: 617-726-1728
Department of Neurology
Clinical Interests
Alzheimer's disease
Memory disorders
Boston: Massachusetts General Hospital
Medical Education
MD, PhD, Stanford University School of Medicine
Residency, Massachusetts General Hospital
Fellowship, Massachusetts General Hospital
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Foreign Languages
Patient Age Group
Accepting New Patients
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The Kelleher laboratory studies the molecular and cellular mechanisms underlying cognition and cognitive disorders. Our prior work established an essential role for translational regulation in long-lasting forms of synaptic plasticity and memory, and further defined an essential MAPK-dependent pathway coupling synaptic activation to the dendritic protein synthesis machinery. Current research projects are directed toward defining the molecular mechanisms regulating local protein synthesis in neurons, and understanding how these translational mechanisms contribute to normal cognition and the modification of synaptic connectivity in the mammalian brain. Examination of the role of defective translational control in the pathogenesis of specific neuropsychiatric disorders, particularly mental retardation and autism, is a closely related effort. In a complementary line of research, the laboratory is also investigating the molecular and cellular mechanisms responsible for neurodegenerative dementia, with a focus on the role of altered presenilin function in Alzheime?s disease and frontotemporal dementia. Due to the complexity of these problems, which span the gap from molecules to cognitive function, the laboratory employs a multidisciplinary approach, including conditional and inducible genetic manipulations in mice, biochemical, molecular and cell biological analysis, slice electrophysiology and mouse behavior.


View my most recent publications at PubMed

1. T cells and stromal fibroblasts in human tumor microenvironments represent potential therapeutic targets. Barnas JL, Simpson-Abelson MR, Yokota SJ, Kelleher RJ, Bankert RB. Cancer Microenviron. 2010 Mar 31;3(1):29-47. PMID: 21209773
2. Genetics. Gamma-secretase and human disease. Kelleher RJ 3rd, Shen J. Science. 2010 Nov 19;330(6007):1055-6. No abstract available. PMID: 21097925
3.Reciprocal functional modulation of the activation of T lymphocytes and fibroblasts derived from human solid tumors. Barnas JL, Simpson-Abelson MR, Brooks SP, Kelleher RJ Jr, Bankert RB. J Immunol. 2010 Sep 1;185(5):2681-92. Epub 2010 Aug 4. PMID: 20686130

Study reveals mechanism behind most common form of inherited Alzheimer’s disease

A study from MGH and BWH researchers reveals for the first time exactly how mutations associated with the most common form of inherited Alzheimer’s disease produce the disorder’s devastating effects. The paper provides an possible explanation for the failure of drugs designed to block presenilin activity.

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Phone: 617-726-1728