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I am a neurocritical care and acute stroke physician with research expertise in the medical genetics of complex diseases, specifically ischemic and hemorrhagic stroke. My lab is dedicated to using genetic tools to explore the biology and pathophysiology that underlies acute brain injuries such as ischemic and hemorrhagic stroke, with the ultimate goal of identifying new drug targets to modify risk of, and recovery from, these debilitating diseases.
I have been involved in a number of genome-wide association studies of intracerebral hemorrhage and ischemic stroke (led by Dr. Jonathan Rosand), and have undertaken a key role in studies of the mitochondrial genome in ischemic stroke. This research has led to the discovery of novel genes and pathways involved in stroke, and has raised new questions regarding the role of energy metabolism in acute brain injury. My current work is focused on the influence of bioenergetics on the risk of stroke, particularly heritable differences in oxidative function. I am also the MGH Principal Investigator for the Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial, a Phase 3 clinical trial, sponsored by the NIH, examining the impact of intensive glucose control immediately following ischemic stroke on outcome.
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