publications

Original Publications
Chapters, Reviews & Invited Commentaries

Original Publications

Kim, D.Y., Carey, W.B., MacKenzie Ingano, L.A., Wang, H., Yang, L.B., Pettingell, W.H., Lee, V. M.-Y., Woolf, C.J., Kovacs, D.M. BACE1 regulates voltage-gated sodium channel levels and activity. Nat. Cell Biol., 2007 9:755-764. pdf

Huttunen, H.J., Greco, C., Kovacs, D.M. Knockdown of ACAT-1 suppresses amyloidogenic processing of APP. FEBS Lett., 2007, 581:1688-92. pdf

Haapasalo, A., Kim, D.Y., Carey, W.B., Pettingell, W.H., Kovacs, D.M. Presenilin/γ-secretase-mediated cleavage regulates association of LAR receptor tyrosine phosphatase with β-catenin. J. Biol.Chem., 2007, 282:9063-72. pdf

Carey, W.B., Kim, D.Y., Kovacs, D.M. PS1/γ-secretase and a α-secretase-like proteases cleave human MHC class I proteins. Biochem. J., 2007, 401:121-7. pdf

Zhang, M., Haapasalo, A., Kim, D.Y., MacKenzie Ingano, L.A., Pettingell, W.H., Kovacs, D.M. Presenilin/γ-secretase activity regulates protein clearance from the endocytic recycling compartment. Faseb J., 2006, 20:1176-8. pdf

Kovacs, I., Lentini, K.M., MacKenzie Ingano, L.A., Kovacs, D.M. Presenilin1 forms aggresomal deposits in response to heat shock. J. Mol. Neurosci., 2006, 29:9-20.

Kim, D.Y, MacKenzie Ingano, L.A., Carey, W.B., Pettingell, W., Kovacs, D.M. Presenilin/γ-secretase-mediated cleavage of the voltage-gated sodium channel β2 subunit regulates cell adhesion and migration. J. Biol. Chem. 2005, 280:23251-23261. pdf

Hutter-Paier, B., Huttunen, H.J., Puglielli, L., Eckman, C.B., Kim, D.Y., Hofmeister, A., Moir, R.D., Domnitz, S.B., Frosch, M.P., Windisch, M., Kovacs, D.M. The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer’s disease. Neuron, 2004, 44:227-238. pdf

Puglielli, L., Ellis, B.C., MacKenzie Ingano, L.A., Kovacs, D.M. Role of acyl-coenzyme A: cholesterol acyltransferase activity in the processing of the amyloid precursor protein. J. Mol. Neurosci., 2004, 24:93-96.

Puglielli, L., Ellis, B.C., Saunders, A.J., Kovacs, D.M. Ceramide stabilizes BACE1 and promotes amyloid b-peptide biogenesis. J. Biol. Chem., 2003, 278:19777-19783. pdf

Kim, D.Y, MacKenzie Ingano, L.A., Kovacs, D.M. Nectin-1α, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/γ-secretase cleavage. J. Biol. Chem., 2002, 277:49976-49981. pdf

Puglielli, L., Konopka, G., Chang, T.Y., Tanzi, R.E., Kovacs, D.M. Acyl-coenzyme A:cholesterol acyltransferase modulates the generation of the amyloid β-peptide. Nat. Cell Biol. 2001, 3, 905-912. pdf

MacKenzie Ingano, L., Lentini, K.M., Kovacs, I., Tanzi, R.E., Kovacs, D.M. Cytoplasmic presenilin aggregates in proteasome inhibitor treated cells. Ann. NY Acad. Sci. 2000, 920:259-260.

Reviews

Huttunen, H.J. and Kovacs, D.M. Cholesterol and β-amyloid. In: Sisodia, S.S. and Tanzi, R.E. (eds) Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. Springer. 2007, 93-111.

Puglielli, L., Tanzi, R.E., and Kovacs, D.M. Alzheimer’s disease: the cholesterol connection. Nat. Neurosci., 2003, 6:345-351. pdf

Tanzi, R.E. and Kovacs, D.M. Alpha2-macroglobulin. Wiley Encyclopedia of Mol. Med., 2002, 5:142-143.

Puglielli, L. and Kovacs, D.M. Alzheimer's disease: 100 years later. Revista Medica de Chile, 2001:129:569-575.

Puglielli, L., MacKenzie Ingano, L.A., Tanzi, R.E., Kovacs, D.M. The amyloid precursor protein V717I mutation increases susceptibility to cell death in a cholesterol-dependent manner. In: Iqbal, K. et al. (eds) Alzheimer's disease: Advances in Etiology, Pathogenesis and Therapeutics. John Wiley & Sons Ltd., 2001:469-477. pdf

Kovacs, D.M. Alpha2-macroglobulin in late-onset Alzheimer's disease. Exp. Geron. 2000, 35:473-479.

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