Original Publications
Chapters, Reviews & Invited Commentaries

Original Publications:

Palmert, M.R., Golde, T.E., Cohen, M.L., Kovacs, D.M., Tanzi, R.E., Gusella, J.F., Usiak, M.F., Younkin, L.H., Younkin, S.G. Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science 1988; 241:1080-1084.

Autilio-Gambetti, L., Morandi, A., Tabaton, M., Schaetzle, B., Kovacs, D.M. , Perry, G., Greenberg, B., Gambetti, P. The amyloid precursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types. Febs Lett. 1988; 241:94-98.

Palmert, M.R., Podlisny, M.B., Golde, T.E., Cohen, M.L., Kovacs, D.M., Tanzi, R.E., Gusella, J.F., Whitehouse, P.J., Witker, D.S., Oltersdorf, T., Younkin, L.H., Selkoe, D.J., Younkin, S.G. Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products. Advances in Neurology 1990; 51:181-184.

LeBlanc, A.C., Kovacs, D.M., Chen, H.J., Villari, F., Tykocinski, M.L., Autilio-Gambetti, L., Gambetti, P. Role of amyloid precursor protein: Study with anti-sense transfection of human neuroblastoma cells. J. Neurosci. Res. 1992; 31:635-645.

Miner, L.L., Pandalai, S.P., Weisberg, E.P., Sell, S., Kovacs, D.M., Kaplan, B.B. Cold-induced alterations in the binding of adrenomedullary nuclear proteins to the promoter region of the tyrosine hydroxylase gene. J. Neurosci. Res. 1992; 33:10-18.

Kovacs, D.M., Kaplan, B.B. Discordant estimates of TPA-induced CMV promoter activity as determined by reporter gene mRNA levels and enzymatic activity. Biochem. Biophys. Res. Commun. 1992; 189:912-918.

Kovacs, D.M., Wasco, W., Witherby, J., Felsenstein, K.M., Brunel, F., Roeder, R.G., Tanzi, R.E. The upstream stimulatory factor functionally interacts with the Alzheimer amyloid B-protein precursor gene. Hum. Mol. Gen. 1995; 4:1527-1533.

Kovacs, D.M., Fausett, H.J., Page, K.J., Kim, T.-W., Moir, R.D., Merriam, D.E., Hollister, R.D., Hallmark, O.G., Mancini, R., Felsenstein, K.M., Hyman, B.T., Tanzi, R.E., Wasco, W. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nature Medicine 1996; 2:224-229.

Tanzi, R.E., Kovacs, D.M., Kim, T.-W., Moir, R.D., Guenette, Y.S., Wasco, W. The gene defects responsible for familial Alzheimer's disease. Neurobiology of Disease , 3, 159-168 (1996).

Seeger, M., Nordstedt, C., Petanceska, S., Kovacs, D.M., Gouras G.K., Hahne, S., Fraser, P., Levesque. L., Czernik, A.J., St George-Hyslop, P., Sisodia, S.S., Thinakaran, G., Tanzi, R.E., Greengard, P., Gandy S. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc. Natl. Acad. Sci. (USA) 1997; 94, 5090-5094.

Kim, T.-W., Pettingell, W.H., Jung, Y.K., Kovacs, D.M., Tanzi, R.E. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science. 1997; 277, 373-376. pdf

Kovacs, D.M., Na, S., Tanzi, R.E. Presenilin mutations in Alzheimer's Disease. Clin. Neurosc. 1998; 51, 24-25.

Kovacs, D.M., Mancini, R., Henderson, J., Schmidt, S.D., Na, S.J., Kim, T.-W., Tanzi, R.E. Staurosporine-induced activation of caspase 3 is potentiated by presenilin 1 FAD mutations in human neuroglioma cells. J. Neurochem., 1999; 73, 2278-2285. pdf

Abbenante, G., Kovacs, D.M., Leung, D.L., Craik, D.J., Tanzi, R.E., Fairlie, D.P. Inhibitors of b-amyloid formation based on the b-secretase cleavage site. Biochem. Biophys. Res. Comm. 2000; 268, 133-135. pdf

MacKenzie Ingano, L., Lentini, K.M., Kovacs, I., Tanzi, R.E., Kovacs, D.M. Cytoplasmic presenilin aggregates in proteasome inhibitor treated cells. Ann. NY Acad. Sci. 2000, 920:259-260.

Puglielli, L., Konopka, G., Chang, T.Y., Tanzi, R.E., Kovacs, D.M. Acyl-coenzyme A:cholesterol acyltransferase modulates the generation of the amyloid b-peptide. Nat. Cell Biol. 2001, 3, 905-912. pdf

Kim, D.Y, MacKenzie Ingano, L.A., Kovacs, D.M. Nectin-1a, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/g-secretase cleavage. J. Biol. Chem., 2002, 277:49976-49981. pdf

Back to Top

Chapters, Reviews & Invited Commentaries:

Autilio-Gambetti, L., Morandi, A., Kovacs, D.M., Tabaton, M., Schaetzle, B., Hauer, C., Groger, D.K., Tykocinski, M.L., Perry, G., Greenberg, B.D., Satish, S., Cornette, J., Gambetti, P. Amyloid precursor protein in cell cultures: a 130 kDa polypeptide. Prog. Clin. Biol. Res. (US) In: Alzheimer's Disease and Related Disorders, (eds) Iqbal, K. and Wisniewski, H.M. 1989; 317:985-990.

Palmert M.R., Podlisny M.B., Golde T.E., Cohen, M.L., Kovacs, D.M., Tanzi, R.E., Gusella, J.F., Whitehouse P.J., Witker, D.S., Oltersdorf, T., Younkin L.H., Selkoe, D.J., Younkin, S.G. The B amyloid protein precursor: mRNAs, membrane associated forms, and soluble derivatives. Prog. Clin. Biol. Res. (US) In: Alzheimer's Disease and Related Disorders, (eds) Iqbal, K. and Wisniewski, H.M. 1989; 317:971-984.

Tanzi, R.E., Romano, D., Gaston, S., Crowley, A., Bush, A., Peppercorn, J., Paradis, M., Pettingell, W., Gurubhagavatula, S., Kovacs, D.M., Haines, J., St George-Hyslop, P., Wasco, W. The diverse molecular nature of Alzheimer's disease. In: Amyloid Protein Precursor in Development, Aging and Alzheimer's Disease. Masters, C.L. et al. (eds) Springer-Verlag, Heidelberg. 1994; 181-189.

Tanzi, R.E., Kovacs, D.M., Kim, T.-W., Moir, R., Guenette, S., Wasco, W. The Presenilin genes and their role in early-onset familial Alzheimer's disease. Alzheimer's Disease Review, 1996, 1:91-98.

Tanzi, R.E., Kim, T.-W., Kovacs, D.M., Guenette, Y.S., Moir, R.D., Hyman, B.T, Wasco, W. The genes responsible for familiar Alzheimer's disease: toward a common etiological pathway. In: Iqbal, K. et al. (eds) Alzheimer's disease: Biology, Diagnosis and Therapeutics. John Wiley & Sons Ltd., 1997; 63-69.

Tanzi, R.E., Kim, T.-W. , Kovacs, D.M., Wasco, W., Moir, R.D., Pettingell, W., Henderson, J. and Mancini, R. Alternative endoproteolysis of the presenilins and familial Alzheimer's disease. In: Presenilins and Alzheimer's disease. (Younkin, S.G., Tanzi, R.E. and Christen, Y., eds), Springer-Verlag, New York, NY., 1998:19-26.

Kovacs, D.M. and Tanzi, R.E. Molecular determinants of FAD: Presenilin 1 mutations. Cell. Mol. Life Sciences. 1998; 54, 902-909.

Kovacs, D.M., Mancini, R., Na, S., Kim, T.-W., Tanzi, R.E. Caspase cleavage of presenilin 1 is increased in apoptotic cells as a result of familial Alzheimer's disease mutations. In: Iqbal, K. et al. (eds) Alzheimer's disease: Biology, Diagnosis and Therapeutics. John Wiley & Sons Ltd., 1999:607-612.

Kovacs, D.M. Alpha2-macroglobulin in late-onset Alzheimer's disease. Exp. Geron. 2000, 35:473-479.

Puglielli, L., MacKenzie Ingano, L.A., Tanzi, R.E., Kovacs, D.M. The amyloid precursor protein V717I mutation increases susceptibility to cell death in a cholesterol-dependent manner. In: Iqbal, K. et al. (eds) Alzheimer's disease: Advances in Etiology, Pathogenesis and Therapeutics. John Wiley & Sons Ltd., 2001:469-477. pdf

Puglielli, L. and Kovacs, D.M. Alzheimer's disease: 100 years later. Revista Medica de Chile, 2001:129:569-575.

Tanzi, R.E. and Kovacs, D.M. Alpha2-macroglobulin. Wiley Encyclopedia of Mol. Med., 2002, 5:142-143.

Puglielli, L., Tanzi, R.E., and Kovacs, D.M. Alzheimer’s disease: the cholesterol connection. Nat. Neurosci., 2003, 6:345-351. pdf

Back to Top