Explore current research projects in the Department of Neurology or search our open clinical trials and medical research studies.

Albers Lab at MIND - Mark W. Albers
Albers Lab at MIND - Mark W. Albers

The Albers’s Laboratory uses the olfactory system of mice and humans to elucidate early pathologic events of neurodegeneration.

Bacskai Lab at MIND
Bacskai Lab at MIND

Brian Bacskai's laboratory uses sophisticated optical techniques to address fundamental questions in Alzheimer's disease research.

Berezovska Lab - Presenilin Group Alzheimer Research Unit
Berezovska Lab - Presenilin Group Alzheimer Research Unit

The research goal of Dr. Berezovska's lab is to study the cellular and molecular mechanisms of Alzheimer's disease pathology.

Bianchi Sleep Informatics Laboratory
Bianchi Sleep Informatics Laboratory

Dr. Bianchi's Sleep Informatics Laboratory focuses on understanding human sleep, in health and disease, through a combination of diverse analytical methods and novel device technology.

Breakefield Laboratory - Xandra O. Breakefield
Breakefield Laboratory - Xandra O. Breakefield

The Breakefield laboratory uses molecular genetic techniques to elucidate the etiology of inherited neurological diseases and to develop vectors which can deliver genes to the nervous system for therapeutic purposes.

Buonanno & Vaina Lab
Buonanno & Vaina Lab

Neurology of Vision research laboratory for Ferdinando S. Buonanno and Lucia M. Vaina at Massachusetts General Hospital

Cash, Sydney S., PhD - Cortical Physiology Laboratory
Cash, Sydney S., PhD - Cortical Physiology Laboratory

We combine microelectrode and macroelectrode recording and computing techniques to study brain activity, mechanisms for brain machine interface, and the neurophysiology of epilepsy.

Chemical Genomics of Neuropsychiatric & Neurological Disease - Haggarty Laboratory
Chemical Genomics of Neuropsychiatric & Neurological Disease - Haggarty Laboratory

The Chemical Genomics Laboratory (CGL) is unraveling the molecular mechanisms underlying neuroplasticity to develop novel, targeted therapeutics for the treatment of neuropsychiatric and neurological diseases.

Clark Lab
Clark Lab

MIND Informatics develops and applies integrative computational methods in biomedical and brain research, working with leading clinicians and researchers to understand and cure neurological disorders.

Cole, Andrew J., Epilepsy Clinical Research
Cole, Andrew J., Epilepsy Clinical Research

Dr. Andrew J. Cole’s interests as a research investigator include clinical trials, clinical neurology, epilepsy, and basic neuroscience research.

Dickerson Lab
Dickerson Lab

Researchers in Brad Dickerson's Laboratory seek to understand the relationships between brain anatomy, physiology, and behavior in humans across the lifespan and in those with neurodegenerative diseases.

Difiglia Laboratory - Cellular Neurobiology
Difiglia Laboratory - Cellular Neurobiology

Marian M. DiFiglia, PhD, is investigating the role of the HD mutation in the molecular and cellular events leading to neurodegeneration.

Eichler Lab
Eichler Lab

Dr. Florian Eichler's lab studies monogenetic lipid metabolism disorders of the nervous system at the Massachusetts General Hospital and Harvard Medical School.

Flaherty Lab
Flaherty Lab

Alice W. Flaherty, MD, PhD has a dual appointment as associate professor of neurology, and of psychiatry at Harvard Medical School.

Frosch Lab
Frosch Lab

My laboratory is interested in the development and characterization of animal models of human neurodegenerative diseases, particularly Cerebral amyloid angiopathy (CAA), Alzheimer and Parkinson diseases.

Gomez-Isla Lab
Gomez-Isla Lab

Dr. Gomez-Isla investigates the neurobiology of normal aging, Alzheimers, and other dementias.

Gomperts Lab
Gomperts Lab

The Gomperts lab investigates Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease

Greenberg, Steven M. - Cerebral Amyloid Angiopathy Research Lab
Greenberg, Steven M. - Cerebral Amyloid Angiopathy Research Lab

Research on the pathogenesis, diagnosis and treatment of cerebral amyloid angiopathy (CAA), a cause of cerebral hemorrhage in the elderly.

Hersch Laboratory, Steven M. Hersh, MD, PhD
Hersch Laboratory, Steven M. Hersh, MD, PhD

Led by Dr. Hersch, the Laboratory investigates Huntington’s disease using transgenic mouse models and human brain tissue. Research also includes HD clinical trials.

Hyman Lab
Hyman Lab

The Hyman lab focuses on research in neural system failure underlying cognitive loss in Alzheimer’s disease.

Kazantsev Drug Discovery Lab
Kazantsev Drug Discovery Lab

The Kazantsev lab is focused on discovering therapeutic agents for Huntington's and Parkinson's diseases using high throughput screening, rational drug design, and medicinal chemistry lead optimization.

Kovacs Lab, Neurobiology of Disease Laboratory at MIND
Kovacs Lab, Neurobiology of Disease Laboratory at MIND

Molecular research of neurodegeneration in Alzheimer’s disease (AD) focused on identifying cellular pathways regulating the generation of the toxic beta-amyloid protein (Abeta).

MassGeneral Institute for Neurodegenerative Disease (MIND)
MassGeneral Institute for Neurodegenerative Disease (MIND)

The MassGeneral Institute for Neurodegenerative Disease (MIND) is a research center for Alzheimer’s, ALS (Lou Gehrig’s), Huntington’s, Parkinson’s and other neurodegenerative diseases. The Institute's mission is to accelerate research discoveries that will lead to treatment and cures.

MIND / Neurology Research
MIND / Neurology Research

The MassGeneral Institute for Neurodegenerative Disease (MIND) is poised to change the future for people living with neurodegenerative disease.

MingMing Ning MD, MMSc, Clinical Proteomics Research Center
MingMing Ning MD, MMSc, Clinical Proteomics Research Center

The Clinical Proteomics Research Center explores neurovascular pathophysiology using a translational approach - with the goal of developing prognostic tools to guide clinical decision-making.

Moir Lab
Moir Lab

Dr. Robert Moir's research focuses on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease and aging.

Neurological Clinical Research Institute
Neurological Clinical Research Institute

The Neurological Clinical Research Institute (NCRI) at Mass. General is experienced in developing, facilitating, and conducting multicenter clinical trials in Amyotrophic Lateral Sclerosis (ALS) and other neurological diseases.

Neurological Clinical Research Institute
Neurological Clinical Research Institute

The Neurological Clinical Research Institute (NCRI) at Mass. General is experienced in developing, facilitating, and conducting multicenter clinical trials in Amyotrophic Lateral Sclerosis (ALS) and other neurological diseases.

Neurology of Vision Lab
Neurology of Vision Lab

Drs. Vaina and Buonanno's Neurology of Vision Lab links stroke neurology to neuroscience and multimodal brain imaging, to offer diagnosis and treatment of disorders of the brain affecting visual perception and cognition.

Neuroscience Center
Neuroscience Center

With faculty members from the departments of Neurology, Radiology, Pediatrics, and Anesthesia and Critical Care, the Neuroscience Center works to understand the biology of neurological disorders and develop novel methods of diagnosis and treatment.

Pediatric Epilepsy Research Lab: Kevin J. Staley, MD
Pediatric Epilepsy Research Lab: Kevin J. Staley, MD

The Pediatric Epilepsy Research Lab studies how neuronal ion transport and synaptic plasticity alter the spread of epileptic activity in neural networks.

Sadri-Vakili Neuroepigenetics Laboratory
Sadri-Vakili Neuroepigenetics Laboratory

The laboratory focuses on identifying epigenetic alterations that regulate gene expression in brain disorders, and investigates whether these alterations are heritable across multiple generations.

Schmahmann, Jeremy D., MD - Laboratory for Neuroanatomy and Cerebellar Neurobiology
Schmahmann, Jeremy D., MD - Laboratory for Neuroanatomy and Cerebellar Neurobiology

I am interested in the structure and function of the cerebellum, and in the cerebral and cerebellar roles in cognition and emotion. We perform neuroanatomical tract tracing studies in monkey; structural and functional MRI and PET in patients and controls; and we treat and study patients with ataxia and/or cognitive disorders.

Schwarzschild Lab - Molecular Neurobiology Laboratory
Schwarzschild Lab - Molecular Neurobiology Laboratory

The Schwarzschild lab targets three purines—adenosine, caffeine and urate—in pursuit of improved therapy for Parkinson’s and related neurodegenerative diseases.

Stroke Service Research
Stroke Service Research

Clinical stroke research is critical to the prevention and treatment of this disabling disease. Our research may take the form of clinical trials, or studies that follow patients over time.

Tannous Lab - Experimental Therapeutics and Molecular Imaging Laboratory
Tannous Lab - Experimental Therapeutics and Molecular Imaging Laboratory

Bakhos Tannous, PhD – Research focus in molecular Imaging, gene transfer technologies and high throughput screening aiming at finding novel therapeutics against brain tumors.

Tanzi Lab - Genetics and Aging Research Unit
Tanzi Lab - Genetics and Aging Research Unit

Dr. Rudolph Tanzi is carrying out genome-wide association screens to identify novel genes associated with AD and autism spectrum disorders.

TRANSCEND Research Laboratory, Martha Herbert, MD, PhD
TRANSCEND Research Laboratory, Martha Herbert, MD, PhD

TRANSCEND. Treatment Research and NeuroSCience Evaluation of Neurodevelopmental Disorders.

Vaina & Buonanno Lab
Vaina & Buonanno Lab

Dr. Vaina's Neurology of Vision Lab links stroke neurology to neuroscience and multimodal brain imaging to offer diagnosis and treatment of disorders of the brain affecting visual perception and cognition.

Young Laboratory - Anne B. Young, MD
Young Laboratory - Anne B. Young, MD

Dr. Young’s laboratory is examining the role of the protein alpha-synuclein, which plays a key role in the death of dopamine-producing brain cells in the Parkinson’s disease and other diseases with similar symptoms.