Research

Explore current research projects in the Department of Neurology or search our open clinical trials and medical research studies.

Research Labs

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  • Advanced Tissue Resource Center (ATRC)

    Tissue Nanoarray

    The Advanced Tissue Resource Center in the Department of Neurology at Massachusetts General Hospital serves as a molecular and anatomic neuropathology resource for the Boston neuroscience community. Our research incorporates advanced micro-molecular profiling technologies into studies of human neurodegenerative and psychiatric diseases.

  • Aging & Brain Health Research Group: Alessandro Biffi, MD

    Aging and Brain Health Research Group

    Our research group is focused on risk estimation, treatment and prevention of age-related brain deterioration.

  • Albers Lab at MIND - Mark W. Albers

    Mark W. Albers, MD, PhD

    The Albers’s Laboratory uses the olfactory system of mice and humans to elucidate early pathologic events of neurodegeneration.

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  • Bacskai Lab at MIND

    FLIM plaque

    Brian Bacskai's laboratory uses sophisticated optical techniques to address fundamental questions in Alzheimer's disease research.

  • BADR Lab

    brain tumor x-ray image

    The BADR lab is focused on studying the genetic drivers of malignancy and treatment resistance as well as developing targeted and experimental therapeutics for brain tumors.

  • Berezovska Lab - Presenilin Group Alzheimer Research Unit

    Oksana Berezovska FLIM shows PS1 distribution in different conformation states

    The research goal of Dr. Berezovska's lab is to study the cellular and molecular mechanisms of Alzheimer's disease pathology.

  • Bianchi Sleep Informatics Laboratory

    Sleep Informatics Laboratory

    Dr. Bianchi's Sleep Informatics Laboratory focuses on understanding human sleep, in health and disease, through a combination of diverse analytical methods and novel device technology.

  • Biorepository for Neurological Injury

    The Massachusetts General Hospital Biorepository for Neurological Injury advances research in brain health and recovery by providing data to help researchers understand how genes and other factors contribute to risk of brain disease, recovery from brain injuries and the maintenance of a healthy brain.

  • Bragg Laboratory -- Chemical Neurobiology of Hereditary Dystonia

    Bragg Laboratory

    The laboratory combines gene expression profiling and chemical screening of novel cellular models to understand the pathogenesis of hereditary dystonias.

  • Breakefield Laboratory - Xandra O. Breakefield

    mouse neurons

    The Breakefield laboratory uses molecular genetic techniques to elucidate the etiology of inherited neurological diseases and to develop vectors which can deliver genes to the nervous system for therapeutic purposes.

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  • Cash, Sydney S., PhD - Cortical Physiology Laboratory

    Cortical oscillations

    We combine microelectrode and macroelectrode recording and computing techniques to study brain activity, mechanisms for brain machine interface, and the neurophysiology of epilepsy.

  • Center for Rare Neurological Diseases

    Center for Rare Neurological Diseases

    The Mass General Center for Rare Neurological Diseases (CRND) aims to eradicate rare disorders of the nervous system by leveraging the power of biological insights towards design and implementation of clinical trials.

  • Chemical Genomics of Neuropsychiatric & Neurological Disease - Haggarty Laboratory

    at the bench

    The Chemical Genomics Laboratory (CGL) is unraveling the molecular mechanisms underlying neuroplasticity to develop novel, targeted therapeutics for the treatment of neuropsychiatric and neurological diseases.

  • Clark Lab

    Tim Clark informatics

    MIND Informatics develops and applies integrative computational methods in biomedical and brain research, working with leading clinicians and researchers to understand and cure neurological disorders.

  • Cole, Andrew J., Epilepsy Clinical Research

    MRI of brain superimposed over pathology slide

    Dr. Andrew J. Cole’s interests as a research investigator include clinical trials, clinical neurology, epilepsy, and basic neuroscience research.

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  • Dickerson Lab

    Alzheimer's disease imaging signature

    Researchers in Brad Dickerson's Laboratory seek to understand the relationships between brain anatomy, physiology, and behavior in humans across the lifespan and in those with neurodegenerative diseases.

  • Difiglia Laboratory - Cellular Neurobiology

    Marian DiFiglia, PhD

    Marian M. DiFiglia, PhD, is investigating the role of the HD mutation in the molecular and cellular events leading to neurodegeneration.

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  • Eichler Lab

    Florian Eichler, MD, dorsal root ganglia

    Dr. Florian Eichler's lab studies monogenetic lipid metabolism disorders of the nervous system at the Massachusetts General Hospital and Harvard Medical School.

  • Eyal Y. Kimchi, MD, PhD -- Delirium Lab

    The Delirium Lab at Massachusetts General Hospital is committed to determining the causes and treatments of delirium through a combination of translational and clinical research.

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  • Flaherty Lab

    Functional Magnetic Resonance Image

    Alice W. Flaherty, MD, PhD has a dual appointment as associate professor of neurology, and of psychiatry at Harvard Medical School.

  • Frosch Lab

    Matthew P. Frosch, MD, PhD

    “Development and characterization of animal models of human neurodegenerative diseases...”

  • Functional Neurology Research Group

    Functional Neurology Research Group

    The Functional Neurology Research Group at Massachusetts General Hospital, led by David Perez, MD, aims to identify biomarkers of disease, prognosis and treatment response for Functional Neurological Disorders.

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  • Global Neurology Research Group

    Baby with cap

    The Global Neurology Research Group, part of the Department of Neurology and the Neurological Clinical Research Institute, finds innovative solutions to improve the quality of neurological care in low- and middle- income countries.

  • Glykys Lab

    Neurons

    Dr. Glykys studies how seizures are generated in the pediatric brain and how we can enhance the brain’s inhibition system to treat seizures.

  • Gomez-Isla Lab

    APOE and PRNP

    Dr. Gomez-Isla investigates the neurobiology of normal aging, Alzheimers, and other dementias.

  • Gomperts Lab

    The Gomperts lab investigates Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease

  • Greenberg, Steven M. - Cerebral Amyloid Angiopathy Research Lab

    Angiopathy.org logo

    Research on the pathogenesis, diagnosis and treatment of cerebral amyloid angiopathy (CAA), a cause of cerebral hemorrhage in the elderly.

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  • Hersch Laboratory, Steven M. Hersh, MD, PhD

    Hersch Laboratory

    Led by Dr. Hersch, the Laboratory investigates Huntington’s disease using transgenic mouse models and human brain tissue. Research also includes HD clinical trials.

  • Hyman Lab

    F11 synapse rescue with treatment b a hz Courtesy of Tara Spires-Jones and Brad Hyman

    The Hyman lab focuses on research in neural system failure underlying cognitive loss in Alzheimer’s disease.

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  • Kazantsev Drug Discovery Lab

    aggregate inhibition and promotion inclusion formation - small molecule inhibitors

    The Kazantsev lab is focused on discovering therapeutic agents for Huntington's and Parkinson's diseases using high throughput screening, rational drug design, and medicinal chemistry lead optimization.

  • Kovacs Lab, Neurobiology of Disease Laboratory at MIND

    Confocal images of enriched cultures expressing Navβ2 wildtype

    Molecular research of neurodegeneration in Alzheimer’s disease (AD) focused on identifying cellular pathways regulating the generation of the toxic beta-amyloid protein (Abeta).

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  • Laboratory for NeuroImaging of Coma and Consciousness

    Institute for NeuroImaging of Coma and Consciousness

    Dr. Brian Edlow’s Laboratory for NeuroImaging of Coma and Consciousness (NICC) aims to improve acute care and long-term outcomes for patients with coma and other disorders of consciousness caused by traumatic brain injury.

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  • MassGeneral Institute for Neurodegenerative Disease (MIND)

    The MassGeneral Institute for Neurodegenerative Disease (MIND) is a research center for Alzheimer’s, ALS (Lou Gehrig’s), Huntington’s, Parkinson’s and other neurodegenerative diseases. The Institute's mission is to accelerate research discoveries that will lead to treatment and cures.

  • MingMing Ning MD, MMSc, Clinical Proteomics Research Center

    From bench to bedside, our center works to find biomarkers from proteomics mass spect data

    The Clinical Proteomics Research Center explores neurovascular pathophysiology using a translational approach - with the goal of developing prognostic tools to guide clinical decision-making.

  • Moir Lab

    Dr. Robert Moir's research focuses on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease and aging.

  • Moura, Lidia M. V. R., MD, MPH - NeuroValue Health Services Research Lab

    Dr. Lidia Moura

    We use established health services research methods to identify and compare alternative delivery models for achieving desired outcomes. We have a particular interest in strategies for reducing costs while improving the quality of care. The ultimate mission of our group is to design and implement coordinated care models for neurological care of high value.

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  • Neurological Clinical Research Institute

    Neurological Clinical Research Institute

    The Neurological Clinical Research Institute (NCRI) at Mass. General is experienced in developing, facilitating, and conducting multicenter clinical trials in Amyotrophic Lateral Sclerosis (ALS) and other neurological diseases.

  • Neurology of Vision Lab

    brain activity network mapping

    Drs. Vaina and Buonanno's Neurology of Vision Lab links stroke neurology to neuroscience and multimodal brain imaging, to offer diagnosis and treatment of disorders of the brain affecting visual perception and cognition.

  • Neuroscience Center

    Neuroscience Center

    With faculty members from the departments of Neurology, Radiology, Pediatrics, and Anesthesia and Critical Care, the Neuroscience Center works to understand the biology of neurological disorders and develop novel methods of diagnosis and treatment.

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  • Sadri-Vakili Neuroepigenetics Laboratory

    Huntington disease pathogenic mechanisms

    The laboratory focuses on identifying epigenetic alterations that regulate gene expression in brain disorders, and investigates whether these alterations are heritable across multiple generations.

  • Salinas Lab: Joel Salinas, MD

    Salinas Lab

    The Salinas Lab is driven by the guiding hypothesis that our social relationships alter the biology of the brain and are crucial to brain health.

  • Schmahmann, Jeremy D., MD - Laboratory for Neuroanatomy and Cerebellar Neurobiology

    I am interested in the structure and function of the cerebellum, and in the cerebral and cerebellar roles in cognition and emotion. We perform neuroanatomical tract tracing studies in monkey; structural and functional MRI and PET in patients and controls; and we treat and study patients with ataxia and/or cognitive disorders.

  • Schwarzschild Lab - Molecular Neurobiology Laboratory

    adenosine molecule fragment

    The Schwarzschild lab targets three purines—adenosine, caffeine and urate—in pursuit of improved therapy for Parkinson’s and related neurodegenerative diseases.

  • Stroke Service Research

    Stroke Service Research

    Clinical stroke research is critical to the prevention and treatment of this disabling disease. Our research may take the form of clinical trials, or studies that follow patients over time.

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  • Wainger Laboratory

    Brian Wainger, MD, PhD

    The Wainger Lab at Massachusetts General Hospital focuses on how abnormalities of motor and sensory neuron physiology contribute to diseases such as ALS and chronic pain.

  • Wheeler Muscular Dystrophy Research Lab

    wheeler lab

    We study muscular dystrophies with the long-term goal of finding new treatments for patients.

Clinical Trials

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