Stephen J. Haggarty, PhD combines chemical biology, synthetic chemistry, neuroscience, and human genetics to unravel the biologic and chemical mechanisms underlying human memory and mood disorders.
Assistant in Neuroscience, Massachusetts General Hospital
Director, Chemical Neurobiology Laboratory (CNL), Stanley Center for Psychiatric Research, Broad Institute
Dr. Haggarty graduated from The University of British Columbia (Vancouver, Canada) in with a degree in genetics and received his Ph.D. from Harvard University for his work developing methods for high-throughput chemical screening and the identification of small-molecule probes of the cell cycle and chromatin remodeling. Dr. Haggarty then joined the Broad Institute as a research Fellow in the Chemical Biology Program and became a founding member of the Psychiatric Disease Program and the Stanley Center for Psychiatric Research.
Dr. Haggarty’s overall goal is to understand how changes in brain chemistry influence the neural circuits underlying memory and mood. His research program involves combining synthetic chemistry, neuroscience, and human genetics. Using this chemical-genomic approach, members of his group invent new methods for finding small-molecule probes that target key components of the neurocircuitry, and then use these probes to selectively perturb network function at the molecular, cellular, and circuit level.Research Projects Chromatin-Mediated Neuroplasticity in Memory and Mood
The role of chromatin-modifying enzymes in regulating transcriptional programs important to memory and mood are being investigated. Efforts to develop CNS penetrant, isoform selective inhibitors of class I/class II histone deacetylases (HDACs) and histone demethylases implicated in neuroplasticity and testing of these probes in vivo using behavioral models are underway.Related Links