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MassGeneral Institute for Neurodegenerative Disease (MIND)
Dr. Gomperts' basic science interests focus on understanding how dopamine cells and cells of the hippocampus communicate with one another and with their target regions to guide behaviors.
Dr. Gomperts' clinical interests are cognitive impairment and dementias, such as dementia with Lewy bodies and Alzheimer's disease, as well as movement disorders such as Parkinson's disease. His clinical research interests include the development of blood and imaging biomakers for cognitive impairment in dementia with Lewy bodies and Parkinson's disease.
Stephen N. Gomperts, MD, PhD
Could brain amyloid deposition be a factor in early onset dementia in patients with dementia with Lewy bodies (DLB)?
In this clinical study we sought to confirm the hypothesis that brain amyloid deposition, an early feature of Dementia with Lewy Bodies, may account, in part, for its early dementia.We also to determine whether amyloid accumulation contributes to cognitive impairment and dementia in the broad range of parkinsonian diseases. Many patients with Parkinson's disease develop PD with dementia (PDD), a syndrome that overlaps clinically and pathologically with dementia with Lewy bodies; PDD and DLB differ chiefly in the relative timing of dementia and parkinsonism.
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