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Global Neurology Research Group

The Global Neurology Research Group, part of the Department of Neurology at Massachusetts General Hospital, finds innovative solutions to improve the quality of neurological care in low- and middle- income countries.

Advancing Neurological Care Worldwide

Neurological disorders such as epilepsy, stroke, dementia and traumatic brain injuries are more common in low- and middle income countries, where 86% of the world’s population is concentrated.

These neurological disorders can be disabling both physically and mentally, and there is a high human and economic cost associated with them. Many of these diseases come with a stigma attached since they are often misunderstood.

Compounding this problem is that many of these diseases are not well diagnosed or treated due to a lack of trained neurologists and limited access to medical care in these settings.

When last studied, there were 12 African countries with no neurologists, and an additional 23 countries with a ratio of one neurologist to more than five million people in the population. 

The Global Neurology Research Group at Mass General works on projects designed to improve the diagnosis, care and treatment of neurological diseases in these resource-limited settings.

 

Page updated: February 6, 2015

 

 

 

 

  

 

 

 

 

 

Principal Investigator

Farrah Mateen, MD PhD

  • Assistant Professor of Neurology, Harvard Medical School
  • Assistant in Neurology, Massachusetts General Hospital

 

Research Staff

Sarah Clark, BSc, Senior Clinical Research Coordinator

Diederik Koelman, BSc, Master's student, Academic Medical Center, Amsterdam, The Netherlands

Emma Wolper, Research Assistant, Lesley University, Boston, USA

Erica McKenzie, BSc, Medical Student, Queen's University, Ontario, Canada

Mia Borzello, BA, Research Assistant, Cash Laboratory, Harvard Medical School/Massachusetts General Hospital, Boston, USA

Tali Sorets, High school student

 

Staff in Bhutan

Sonam Deki, BComm, Research Assistant, affiliated with Jigme Dorji Wangchuck National Referral Hospital

Lhab Tshering, BSc, Research Assistant, affiliated with Jigme Dorji Wangchuck National Referral Hospital

 

Affiliations

http://asiacenter.harvard.edu/people/farrah-mateen

http://mhinnovation.net/profile/farrah-mateen

 

 From left to right- Sarah, Diederik and Farrah in front of the MGH Neurological Clinical Research Institute Entrance

 

 

Research Projects

Standard EEG on a child in Bhutan 

 

Smartphone EEG in Bhutan- the group is conducting a clinical study to test the feasibility of using a smartphone-based electroencephalograph (EEG) system to diagnose patients with epilepsy in Bhutan, a small, land-locked country between China and India. Funded by Grand Challenges Canada.

 

 

Resources:


Optical Coherence Tomography (OCT) to Assess Brain Development in Infants in Sub-Saharan Africa- Preliminary data suggest that retinal nerve fiber layer measurements may be surrogate markers of early life cortical development. Embryologically, the retina shares derivation with the cerebral cortex, but unlike the cortex, can be visualized noninvasively through a new technology, optical coherence tomography (OCT).  OCT is a portable, affordable, painless, noninvasive medical instrument and has supportive scientific evidence as a surrogate marker of gross measures of neurodevelopment in specific disease states. Interpretation of RNFL thicknesses are automated and colorized so that lay community health care workers can be trained to make basic readings in the field.

We aim to determine whether handheld, noninvasive OCT equipment can reliably assess brain development through measurements of retinal nerve fiber layers in early life and be an effective screening test for some forms of abnormal early life brain development. 

Publications

Mateen FJ, Carone M, Haskew C, Spiegel P.Reportable neurologic diseases in refugee camps in 19 countries. Neurology 2012;79:937-40.

Mateen FJ, Niu J, Gao S, Li S, Carone M, Wijdicks EF, Xu WH. Persistent vegetative state: a comparative study at a Chinese and U.S. referral hospital. Neurocrit Care 2013;18:266-70.

Mateen FJ, Bahl S, Khera A, Sutter RW. Diphtheritic polyneuropathy as detected by acute flaccid paralysis surveillance, India. Emerging Infect Dis 2013;19:1368-73.
 
Berkowitz AL, Mittal M, McLane HC, Shen GC, Muralidharan R, Lyons JL, Shinohara RT, Shuaib A, Mateen FJ. Worldwide reported use of IV-tissue plasminogen activator for acute ischemic stroke. Int J Stroke 2014;9:349-55.

Mateen FJ, Post WS, Sacktor N, Abraham AG, Becker JT, Smith BR, Detels R, Martin E, Phair JP, Shinohara RT; for the Multi-Center AIDS Cohort Study (MACS) Investigators. Long-term predictive value of the Framingham risk score for stroke in HIV-infected vs. HIV-uninfected men. Neurology 2013;81:2094-102.

Schwamm LH. Telehealth: seven strategies to successfully implement disruptive technology and transform health care. Health Aff (Millwood). 2014;33:200-6.

Lyons JL, Coleman M, Engstrom JW, Mateen FJ. International electives in neurology training: a survey of U.S. and Canadian program directors. Neurology 2014;82:119-25.

Bucheli ME, Calderón A, Chicaiza D, Franco C, López R, Digga E, Atassi N, Salameh J, Berry JD. Feedback interaction of research, advocacy, and clinical care applied to ALS research in South America.  Neurology 2013;81:1959-61.

Mateen FJ, Martins N. A health systems constraints analysis for neurological diseases: the example of Timor-Leste. Neurology 2014;82:1274–1276

Fugate JE, Lyons JL, Thakur KT, Smith BR, Hedley-Whyte ET, Mateen FJ. Infectious causes of stroke. Lancet Infect Dis 2014;14:869-80. 

Global Neurology Research Group -- Farrah Mateen, MD, PhD

165 Cambridge St.
Boston, MA 02114

Phone: 617-724-6387
Email: fmateen@partners.org

Public Transportation Access: yes
Disabled Access: yes