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Lab Phone: 617-724-1259
Research Investigator Profile
Michal Arbel (Arbel-Ornath) MSc, PhD
Dr. Arbel's research interests include developing therapeutic strategies to neurodegenerative diseases in which protein misfolding is implicated. Her research focuses on understanding the molecular mechanisms underlying Alzheimer’s disease (AD) that lead to neurodegeneration with the hope that our findings will reveal new therapeutic targets.
Previous work in Dr. Bacskai's lab showed that AD mouse models exhibit calcium dysregulation in the presence of amyloid plaques. Plaques also serve as a reservoir rich in soluble oligomeric forms of Aβ. It is still not known which species of Aβ, soluble oligomers or deposits are the culprit. We are also trying to understand the selective vulnerability of a subpopulation of neurons. My work has demonstrated that specific naturally occurring oligomeric species of Aβ are responsible for calcium dysregulation and involves the activation of NMDA receptors, and requires the presence of ApoE.
My second major project is related to the accumulation of Aβ within the wall of cerebral arteries and capillaries (CAA) that is associated with the majority of AD cases and on its own.
NCBI PubMed link - Arbel-OrnathNCBI PubMed link - Arbel-Ornath
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