Dr. Arbel is a former Alzheimer’s Disease Research Unit fellow in the Neurology Department’s MassGeneral Institute for Neurodegenerative Disease, where she continues her research.
- Lab Phone: 617-724-1259
- MassGeneral Institute for Neurodegenerative Disease
- Neurology, Massachusetts General Hospital
- Harvard Clinical and Translational Science Center
Research Investigator Profile
Michal Arbel (Arbel-Ornath) MSc, PhD
- Instructor in Neurology,
Harvard Medical School
Dr. Arbel's research interests include developing therapeutic strategies to neurodegenerative diseases in which protein misfolding is implicated. Her research focuses on understanding the molecular mechanisms underlying Alzheimer’s disease (AD) that lead to neurodegeneration with the hope that our findings will reveal new therapeutic targets.
Previous work in Dr. Bacskai's lab showed that AD mouse models exhibit calcium dysregulation in the presence of amyloid plaques. Plaques also serve as a reservoir rich in soluble oligomeric forms of Aβ. It is still not known which species of Aβ, soluble oligomers or deposits are the culprit. We are also trying to understand the selective vulnerability of a subpopulation of neurons. My work has demonstrated that specific naturally occurring oligomeric species of Aβ are responsible for calcium dysregulation and involves the activation of NMDA receptors, and requires the presence of ApoE.
My second major project is related to the accumulation of Aβ within the wall of cerebral arteries and capillaries (CAA) that is associated with the majority of AD cases and on its own.
|Research interests||PrPC Proteins, Amyloid Precursor Protein Secretases, Amyloid beta-Protein Precursor, Immunotherapy|
|Research techniques||Multiphoton in vivo imaging, AD mouse models|
|Diseases studied||Alzheimer's disease|
|Lab mailing address||MassGeneral Institute for Neurodegenerative Disease
114 16th Street
Charlestown MA 02129