Cenk Ayata, MD
- Lab Phone: 617-726-0821
- Clinic Phone: 617-724-4484
Research Investigator Profile
Biography
Affiliations
Cenk Ayata, MD
- Assistant Professor,
Harvard Medical School - Assistant in Neurology and Neuroscience,
Massachusetts General Hospital
Research Description
I am a Neurologist and a clinician-scientist dedicated to translational research on neurovascular function and dysfunction. Since my arrival at MGH as a fellow under the invaluable mentorship of Professor Michael A. Moskowitz in 1994, I have dedicated my time to build and integrate electrophysiological and multimodal optical imaging techniques focusing on neurovascular research areas including stroke, migraine, cerebral amyloid angiopathy, and CADASIL. With independent grant supports from American Heart Association, NIH, and Deane Foundation, I explore therapies to augment perfusion and oxygenation in acute stroke (e.g., hyperoxia, induced hypertension, Rho-kinase inhibition), the pathophysiological roles of injury depolarizations in stroke, and targeting spreading depression in migraine.
My research group has authored or co-authored 20 peer-reviewed manuscripts over the past 5 years in high-impact journals including Journal of Clinical Investigation, Brain, Annals of Neurology, Proceedings of the National Academy of Sciences, Stroke, and Journal of Cerebral Blood Flow and Metabolism.
As part of my translational research efforts, I was the Principal Investigator of a randomized, double-blind, placebo-controlled clinical trial of simvastatin against vasospasm after subarachnoid hemorrhage in the MGH NeuroICU, gaining invaluable experience in trial design and conduct. The results have recently been published in Stroke.
| Research interests | Cerebrovascular function and dysfunction, cortical spreading depression |
| Research techniques | Translational research |
| Diseases studied | Stroke, migraine, subarachnoid hemorrhage, CADASIL, amyloid angiopathy |
| NCBI PubMed link | |
| Collaborators | David A. Boas, Karen L. Furie, Paul L. Huang, Eng H. Lo, Michael A. Moskowitz |
| E-mail address | cayata@partners.org |
| Lab mailing address | Massachusetts General Hospital Neurology Research 149 13th Street, Room 6408 Charlestown, MA 02129 |
| Lab website | Stroke Service and Neurovascular Research Lab |
| Clinical interest | Stroke and Neurologic Intensive Care, Vascular Neurology |
| Clinical mailing address | Massachusetts General Hospital Neurology, Suite 835 Wang Ambulatory Care Center 55 Fruit Street Boston, MA 02114 USA |
| Clinical website address | Stroke Service |
