Research Investigator Profile

Cenk, Ayata, MD

Cenk Ayata, MD

  • Assistant Professor,
    Harvard Medical School
  • Assistant in Neurology and Neuroscience,
    Massachusetts General Hospital




    Research Description

    I am a Neurologist and a clinician-scientist dedicated to translational research on neurovascular function and dysfunction. Since my arrival at MGH as a fellow under the invaluable mentorship of Professor Michael A. Moskowitz in 1994, I have dedicated my time to build and integrate electrophysiological and multimodal optical imaging techniques focusing on neurovascular research areas including stroke, migraine, cerebral amyloid angiopathy, and CADASIL. With independent grant supports from American Heart Association, NIH, and Deane Foundation, I explore therapies to augment perfusion and oxygenation in acute stroke (e.g., hyperoxia, induced hypertension, Rho-kinase inhibition), the pathophysiological roles of injury depolarizations in stroke, and targeting spreading depression in migraine.

    My research group has authored or co-authored 20 peer-reviewed manuscripts over the past 5 years in high-impact journals including Journal of Clinical Investigation, Brain, Annals of Neurology, Proceedings of the National Academy of Sciences, Stroke, and Journal of Cerebral Blood Flow and Metabolism.

    As part of my translational research efforts, I was the Principal Investigator of a randomized, double-blind, placebo-controlled clinical trial of simvastatin against vasospasm after subarachnoid hemorrhage in the MGH NeuroICU, gaining invaluable experience in trial design and conduct. The results have recently been published in Stroke.

    Research interests Cerebrovascular function and dysfunction, cortical spreading depression
    Research techniques Translational research
    Diseases studied Stroke, migraine, subarachnoid hemorrhage, CADASIL, amyloid angiopathy
    NCBI PubMed link

    NCBI PubMed Publications

    Collaborators David A. Boas, Karen L. Furie, Paul L. Huang, Eng H. Lo, Michael A. Moskowitz
    E-mail address
    Lab mailing address Massachusetts General Hospital
    Neurology Research
    149 13th Street, Room 6408
    Charlestown, MA 02129
    Lab website Stroke Service and Neurovascular Research Lab
    Clinical interest Stroke and Neurologic Intensive Care, Vascular Neurology
    Clinical mailing address Massachusetts General Hospital
    Neurology, Suite 835
    Wang Ambulatory Care Center
    55 Fruit Street
    Boston, MA 02114 USA
    Clinical website address Stroke Service

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