Brian J. Bacskai, PhD, researches Alzheimer's disease using mulitphoton micrsocopy to observe, in vivo, the anatomy and physiology of specific cell types in the brain.
- Lab Phone: 617-724-5306
- Bacskai Research Laboratory
Research Investigator Profile
Brian J. Bacskai, PhD
- Professor of Neurology,
Harvard Medical School
- Principal Investigator, Neurology,
Massachusetts General Hospital
Using the imaging technique mulitphoton micrsocopy, the senile plaques of Alzheimer's disease can be detected in the brains of living transgenic mice, and characterized with chronic imaging. This detection platform was used to characterize a therapeutic approach to clearing the senile plaques based on immunotherapy, as well as to characterize novel amyloid-targeting ligands in preclinical development for PET imaging in humans.
Current research is aimed at optimizing anti-amyloid-beta therapeutic approaches, and imaging the anatomy and physiology of specific cell types in the brain before and after treatment. Development of novel optical techniques is ongoing, and includes methods to measure protein-protein interactions using fluorescence lifetime imaging microscopy (FLIM), and non-invasive approaches to amyloid imaging in intact animals.
To learn more, visit www.bacskailab.org.
|Research interests||Mulitphoton micrsocopy, senile plaques, anatomy and physiology of brain cells|
|Research techniques||Fluorescence lifetime imaging microscopy (FLIM)|
|Diseases studied||Alzheimer's disease|
|NCBI PubMed link||NCBI PubMed publications|
|Lab mailing address||
MassGeneral Institute for Neurodegenerative Disease
|Related Subspecialty Clinic||Memory Disorders Unit|