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Lab Phone: 617 726 5763
Research Investigator Profile
Christian Badr, PhD
Given the highly aggressive nature of high-grade brain tumors and the poor patient survival, there is an urgent need for new therapeutics.
The focus of my work is on novel imaging tools for cancer translational research as well as the development of new cancer therapies, mainly for brain tumors.
As part of our drug discovery platform, we use bioluminescence-based compound screenings to identify new cancer-targeting compounds. We have so far screened a few thousands of small-molecule compounds with several thousands more to go. This work has so far identified a few molecules that showed potent anti-cancer properties. We are currently validating those compounds, and studying their killing mechanisms, and the signaling pathways they target. We are also working on testing such compounds on various tumor models.
Another arm of my research consists of studying cancer stem cells, particularly glioma stem cells. Those cells are notorious for their resistance to common, standard of care therapies. We are using a whole genome RNAi screening approach to identify new genes that could modulate the glioma stem cells fate and make them more susceptible to cancer therapy.
To learn more, visit the Experimental Therapeutics and Molecular Imaging Laboratory Lab.
Massachusetts General HospitalRoom 6-6101149 13th Street Charlestown, MA 02129
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