Sydney S. Cash, MD, PhD

  • Lab Phone: 617-726-5904
  • Neurology Access Center: 1-855-644-6387

Research Investigator Profile

Sydney S. Cash, MD, PhD

Sydney S. Cash, MD, PhD

  • Assistant Professor of Neurology,
    Harvard Medical School
  • Assistant in Neurology,
    Massachusetts General Hospital

   

 

Research Description

Current research in the lab is, broadly speaking, dedicated to trying to understand normal and abnormal brain activity, particularly oscillations, using multi-modal and multi-scalar approaches. Specifically, we are combining novel microelectrode approaches with non-invasive techniques such as electroencephalography and magnetoencephalography to record directly from both human and animal cortex and subcortical structures. One part of the lab studies the neurophysiology of epilepsy; trying to understand how seizures start and stop and how they might be predicted and terminated. These questions overlap with investigations into the mechanisms of sleep, normal language, auditory, and other cognitive processing.

All of these projects are built on a foundation of combined microelectrode, macroelectrode and non-invasive recording techniques that span information from the level of single action potentials to aggregate activity of millions of neurons. Intensive signal processing and computational techniques are employed to analyze these data sets. Collaborative activities involving neural modeling are aimed at relating these multi-scalar data. Ultimately, all of these projects aim toward the creation of both invasive and non-invasive mechanisms for restoring damaged neuronal function.

To learn more, visit the Cortical Physiology Laboratory (Mass General), or the Cortical Physiology Laboratory at Harvard Medical School.

Research interests Epilepsy, cognition, cortical rhythms, brain-computer interfaces, neurotechnology
Research techniques EEG, MEG, microelectrodes, signal processing, animal models of epilepsy, optogenetics
Diseases studied Epilepsy, Alzheimer's disease
Selected publications
  1. Dykstra AR, Halgren E, Thesen T, Carlson CE, Doyle W, Madsen JR, Eskandar EN, Cash SS. Widespread Brain Areas Engaged during a Classical Auditory Streaming Task Revealed by Intracranial EEG. Front Hum Neurosci. 2011; 5:74.
    View in: PubMed
  2. Truccolo W, Donoghue JA, Hochberg LR, Eskandar EN, Madsen JR, Anderson WS, Brown EN, Halgren E, Cash SS. Single-neuron dynamics in human focal epilepsy. Nat Neurosci. 2011 May; 14(5):635-41.
    View in: PubMed
  3. Chu-Shore CJ, Kramer MA, Bianchi MT, Caviness VS, Cash SS. Network analysis: applications for the developing brain. J Child Neurol. 2011 Apr; 26(4):488-500.
    View in: PubMed
  4. Chan AM, Halgren E, Marinkovic K, Cash SS. Decoding word and category-specific spatiotemporal representations from MEG and EEG. Neuroimage. 2011 Feb 14; 54(4):3028-39.
    View in: PubMed
  5. Dehghani N, Bédard C, Cash SS, Halgren E, Destexhe A. Comparative power spectral analysis of simultaneous elecroencephalographic and magnetoencephalographic recordings in humans suggests non-resistive extracellular media. J Comput Neurosci. 2010 Dec; 29(3):405-21.
    View in: PubMed
NCBI PubMed link NCBI PubMed Publications
Collaborators View all collaborators
E-mail address scash@partners.org
Lab mailing address Massachusetts General Hospital
Neurology, WACC 730
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA
Clinical interests Epilepsy
Clinical address Massachusetts General Hospital
Neurology, WACC 730
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA
Clinical website address Epilepsy Service

 

 

Updated 1/26/2012