Bradford C. Dickerson, MD

Research Investigator Profile

Bradford C. Dickerson, MD

Bradford C. Dickerson, MD

  • Associate Professor of Neurology,
    Harvard Medical School
  • Director of Clinical Applications,
    Morphometry Service
    Massachusetts General Hospital,
  • Co-Director, Neuroimaging Group,
    Gerontology Research Unit

 

Research Description

In Brad Dickerson's Neuroimaging Laboratory, we seek to understand the relationships between brain anatomy, physiology, and behavior in humans across the lifespan and in those with neurodegenerative diseases. We focus on memory and Alzheimer's disease. In our research on the anatomy and physiology of memory, we study brain structure and function using magnetic resonance imaging (structural and functional MRI), and try to understand the roles of various brain regions in normal human memory. Studies of aging include individuals in their '40s and '50s, as well as those in the 60-100+ age range, and seek to identify age-related changes in brain structure and function that relate to memory and cognitive task performance. In our research on Alzheimer's disease, we use MRI to investigate the locations and degrees to which brain regions are affected by the disease, and how these changes relate to clinical symptoms and difficulties with the performance of cognitive tasks.

Recently, we have begun using MRI methods of "ultra" high resolution to study brain structure and function at an unprecedented level of detail.

A special focus of our research is on mild cognitive impairment (MCI), in which individuals demonstrate subtle memory loss that may be the earliest symptom of Alzheimer's disease but which is often difficult to distinguish from the aging process itself.

Research interests

Alzheimer's disease, frontotemporal dementia, memory, aging

Research techniques

Magnetic resonance imaging, fMRI, PET, neuropsychology, histology

Diseases studied Alzheimer's disease, frontotemporal dementia, primary progressive aphasia, cerebral amyloid angiopathy, posterior cortical atrophy
Selected publications
  1. Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance ability. Wang L, Negreira A, Laviolette P, Bakkour A, Sperling RA, Dickerson BC. Hippocampus. 2010 Jan 19. [Epub ahead of print]
  2. Functional Alterations in Memory Networks in Early Alzheimer's Disease. Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, Laviolette PS, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA. Neuromolecular Med. 2010 Jan 13. [Epub ahead of print]
  3. Dickerson BC, Sperling RA. Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging. Behav Neurol 2009;21(1):63-75.
  4. Weierich MR, Wright CI, Negreira A, Dickerson BC, Barrett LF. Novelty as a dimension in the affective brain. Neuroimage. 2009 Sep 28 [epub].
  5. Dickerson BC, Eichenbaum H. The episodic memory system: Circuits and disorders. Neuropsychopharmacology. 2009 Sep 23. [Epub ahead of print] 2009.
NCBI PubMed link NCBI PubMed Publications
E-mail address bdickerson@partners.org
Lab mailing address Massachusetts General Hosptial
149 13th Street, Suite 2691
Charlestown, MA 02155 USA
Lab website Dickerson Laboratory
Clinical interests

Memory, aging, Alzheimer's disease, frontotemporal dementia, primary progressive aphasia

Clinical mailing address Massachusetts General Hospital
Neurology, Suite 835
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA
Clinical website address Memory Disorders Unit, Department of Neurology