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Clinical Phone: 617-726-5156
Matthew P. Frosch, MD, PhD
Research Investigator Profile
A unifying theme in my research is the study of human tissue and animal models of neurodegenerative diseases. My lab focuses on mouse models of cerebral amyloid angiopathy (CAA) in which Aβ (the same peptide as in plaques of Alzheimer's disease) deposits in the walls of blood vessels and is associated with risk of hemorrhage (‘lobar hemorrhages’). We are analyzing the sequence of events leading to Aβ deposition, what determines the distribution of involvement, the consequences for the vessel wall and how CAA responds to treatments that can alter other Aβ deposits. We have described the pattern of disease progression, measured its kinetics and characterized the patterns of growth. We are now focusing on the mechanisms of injury to the vessel wall and on approaches to therapy. We have demonstrated that passive immune therapy can clear CAA, which is of relevance for clinical trials of similar approaches to treating Alzheimer's disease.
Pathology Service, Massachusetts General Hospital
Neurology Service, Massachusetts General Hospital
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