Matthew P. Frosch, MD, PhD
- Clinical Phone: 617-726-5156
Research Investigator Profile
Biography
Affiliations
- Lawrence J. Henderson Associate Professor of Pathology and Health Sciences &
Technology, Harvard Medical School - Director, Neuropathology Service,
Massachusetts General Hospital - Core Leader, Neuropathology Core,
Massachusetts Alzheimer's Disease Research Center
Research Description
A unifying theme in my research is the study of human tissue and animal models of neurodegenerative diseases. My lab focuses on mouse models of cerebral amyloid angiopathy (CAA) in which Aβ (the same peptide as in plaques of Alzheimer's disease) deposits in the walls of blood vessels and is associated with risk of hemorrhage (‘lobar hemorrhages’). We are analyzing the sequence of events leading to Aβ deposition, what determines the distribution of involvement, the consequences for the vessel wall and how CAA responds to treatments that can alter other Aβ deposits. We have described the pattern of disease progression, measured its kinetics and characterized the patterns of growth. We are now focusing on the mechanisms of injury to the vessel wall and on approaches to therapy. We have demonstrated that passive immune therapy can clear CAA, which is of relevance for clinical trials of similar approaches to treating Alzheimer's disease.
| Research interests | Neurodegenerative disease; cerebrovascular diseases; cerebral amyloid angiopathy; experimental neuropathology |
| Research techniques | Mouse modeling; in vivo imaing; quantitative neuropathology; laser capture microdissection |
| Diseases studied | Alzheimer's disease; Cerebral amyloid angiopathy (CAA); Parkinson disease; other dementias |
| Selected publications |
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| NCBI PubMed link | NCBI PubMed Publications |
| Lab mailing address | MassGeneral Institute for Neurodegenerative Disease CNY B114-2700 114 16th Street Charlestown, MA 02129 |
| Lab website | Frosch Lab (Pathology) |
| Clinical interests | Diagnostic neuropathology, including tumors, vascular disease, neurodegenerative diseases |
| Clinical mailing address | C.S. Kubik Laboratory for Neuropathology Pathology Service, Warren 3 Mass General Hospital 55 Fruit Street Boston, MA 02114 |
| Clinical website address |
