Steven M. Hersch, MD, PhD - Clinical and basic science research in neurodegenerative disorders, particularly Huntington's disease (HD)
- Lab Phone: 617-726-8463
- Neurology Access Center: 1-855-644-6387
Biography
Affiliations
Research Investigator Profile
Steven Hersch, MD, PhD
-
Professor of Neurology,
Harvard Medical School -
Associate in Neurology,
Massachusetts General Hospital
Research Description
In recent years, Dr. Hersch has worked on understanding the role of huntingtin protein in the pathogenesis of HD utilizing human brain tissue and transgenic mouse models. At the same time, he has performed clinical research on Huntington’s disease, including clinical trials. Dr Hersch provides expertise in human and transgenic mouse neuropathology and therapeutics discovery using transgenic mouse models, and heads up all testing of potential therapeutic compounds on transgenic mouse models of HD. Three compounds are currently being tested and up to ten are slated for the next year. Steve is also in charge of clinical care provided by the Mass General HD Center of Excellence, and is developing a translational program to rapidly bring research findings into the clinic. He also sees patients in the Movement Disorders unit at Mass General.
To learn more, visit the Hersch Lab.
| Research interests | Transcriptional dysfunction and cellular energetics contributing to HD pathogenesis, the Huntingtin protein, potential therapeutic compounds |
| Research techniques | Transgenic HD mouse models, clinical trials, observational or therapeutic studies, drug compound testing |
| Diseases studied | Huntington's disease |
| Selected publications |
|
| NCBI PubMed link | NCBI PubMed publications |
| E-mail address | hersch@helix.mgh.harvard.edu |
| Lab mailing address | MassGeneral Institute for Neurodegenerative Disease 114 16th Street Charlestown, MA 02129 |
| Clinical interests | Huntington's disease and neurodegenerative diseases |
| Clinical address | Massachusetts General Hospital Neurology, Suite 835 Wang Ambulatory Care Center 55 Fruit Street Boston, MA 02114 USA |
| Clinical website address | Huntington's disease Unit |
Updated 03/21/2012
