Bradley T. Hyman, MD, PhD
- Lab Phone: 617-726-4796
- Neurology Access Center: 1-855-644-6387
Biography
Affiliations
Research Lab
Research Investigator Profile
Bradley T. Hyman, MD, PhD
- John B. Penney Professor of Neurology,
Harvard Medical School - Alzheimer's Unit Director,
MassGeneral Institute for Neurodegenerative Disease - Director,
Massachusetts Alzheimer's Disease Research Center
Research Description
Dr. Hyman’s research program studies the neural system failure that underlies cognitive loss in Alzheimer’s, and how genetics impacts pathophysiology. His laboratory uses transgenic mouse models of Alzheimer’s disease and in vitro systems to examine the roles of presenilin mutations and receptors in neuronal function and on Alzheimer-related processes.
Dr. Hyman’s laboratory has developed in vivo imaging with 2-photon confocal microscopy, enabling observation of neurons in the intact, functioning mouse brain, and tracking the pathological changes that occur during disease processes. His research has shown that that plaques can be reversed by therapeutic application of antibodies.
Dr. Hyman’s laboratory has been pursing the role of the protein alpha-synuclein, which is thought to be involved in the cause of Parkinson’s disease. Using sophisticated optical imaging methods and gene transfer techniques, they have found several kinds of molecules, which can change the metabolism and effects of synuclein, and which may be targets for preventative or neuroprotective treatments.
| Research interests |
Alpha-synuclein, genetics, presenilin mutations |
| Research techniques |
Two-photon confocal microscopy, gene transfer |
| Diseases studied |
Alzheimer’s disease, Parkinson’s disease |
| NCBI PubMed link | NCBI PubMed Publications |
| Lab mailing address | MassGeneral Institute for Neurodegenerative Disease 114 16th Street Charlestown, MA 02129 |
| Clinical interests |
Alzheimer’s disease, Parkinson’s disease |
| Clinical mailing address | Massachusetts General Hospital Neurology, Suite 835 Wang Ambulatory Care Center 55 Fruit Street Boston, MA 02114 USA |
| Clinical website address | Memory Disorders Unit |
Updated 7/3/2012
