Dr. Doo Yeon Kim, of the Genetics and Aging Research Unit, is part of Dr. Dora Kovac's team, which is studying beta-secretase (BACE), an enzyme in the brain which can release small fragments of the amyloid precursor protein (APP), the main ingredient for Alzheimer’s plaques.

  • Lab Phone: 617-764-1505

Research Investigator Profile

Doo Yeon Kim

Doo Yeon Kim

  • Assistant Professor,
    Harvard Medical School

 

Research Description

Dr. Doo Yeon Kim contributed to research that shows that in addition to interacting with APP, BACE has an important role in the electric wiring of the brain around the brain cell membranes, and may explain a higher risk of seizures in AD patients.  BACE can cleave nerve cell surface molecules called sodium channels, which control how nerve cells fire. Excessive amounts of BACE can disrupt the normal electrical activity of these sodium channels, making nerve cells more vulnerable to aberrant firing and perhaps seizures. 

Research interests
Brain signaling, BACE, APP
Diseases studied Alzheimer's disease
Selected publications

Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit.

Gersbacher MT, Kim DY, Bhattacharyya R, Kovacs DM.

Mol Neurodegener. 2010 Dec 23;5(1):61. [Epub ahead of print]PMID: 21182789
NCBI PubMed link NCBI PubMed Publications
E-mail address dkim@helix.mgh.harvard.edu
Lab mailing address

MassGeneral Institute for Neurodegenerative Disease
Building 114, Room
B114-3012 (2935E)
114 16th Street
Charlestown, MA 02129