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Lab Phone: 617-764-1505
Research Investigator Profile
Doo Yeon Kim
Dr. Doo Yeon Kim contributed to research that shows that in addition to interacting with APP, BACE has an important role in the electric wiring of the brain around the brain cell membranes, and may explain a higher risk of seizures in AD patients. BACE can cleave nerve cell surface molecules called sodium channels, which control how nerve cells fire. Excessive amounts of BACE can disrupt the normal electrical activity of these sodium channels, making nerve cells more vulnerable to aberrant firing and perhaps seizures.
Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit.
Gersbacher MT, Kim DY, Bhattacharyya R, Kovacs DM.
MassGeneral Institute for Neurodegenerative DiseaseBuilding 114, RoomB114-3012 (2935E) 114 16th StreetCharlestown, MA 02129
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