Xueyi Li, MD, PhD, has ongoing studies relating to Huntington’s disease and autism spectrum disorders.
Biography
Affiliations
Research Investigator Profile
Xueyi Li, MD, PhD
- Assistant Professor of Neurology,
Harvard Medical School - Assistant in Neuroscience,
Massachusetts General Hospital
Research Description
Dr. Li studies molecular mechanisms of endosomal recycling, a process utilized by mammalian cells to retrieve internalized cell surface proteins for reuse, and explores strategies to harness endosomal recycling for therapeutic intervention in neurological disorders. Dr. Li’s early work at MIND uncovered that the causative mutation of Huntington’s disease compromises the function of Rab11, a critical modulator of endosomal recycling, and showed that augmentation of Rab11 function protects Huntington’s disease neurons die from causes triggered intrinsically or by exposure to harmful stimuli. His studies implicate that enhancing the function of Rab11 has great potential for treating Huntington’s disease. Dr. Li also investigates whether and how endosomal recycling is involved in the pathogenesis of neurodevelopmental disorders, e.g., autism spectrum disorders. Ongoing studies directed by Dr. Li involve validation of Rab11 as a therapeutic target for developing Huntington’s disease therapy and creation of new animal models of autism spectrum disorders.
Dr. Li is also a member of Dr. Marian Difiglia's Cellular Neurobiology Laboratory.
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| NCBI PubMed link | NCBI PubMed publications | |
| E-mail address | xli12@partners.org | |
| Lab mailing address | Attention: Xueyi Li, MD, PhD MassGeneral Institute for Neurodegenerative Disease (MIND) Mailcode: CNY 114, Room 2150 114 16th Street Charlestown, MA 02129 |
Updated 02/9/2012
