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Lab Phone: 617 726 3746
Research Investigator Profile
Robert D. Moir, PhD
My research focuses on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease (AD) and aging. More specifically, receptor/ligand interactions and physiochemical properties that promote pathological protein behavior. Particular emphasis has been placed on the beta-amyloid peptide (A beta), amyloid precursor protein (APP), apolipoprotein E, low density lipoprotein receptor protein (LRP), alpha-2-macroblobulin and the presenilins (PS1 and PS2).
My body of work includes studies that identify LRP as the cell surface receptor for APP and the receptor that mediates the first step in the pathway that ultimately leads to amyloid deposition in AD brain, and characterization of the role and importance of metals in the pathological physiochemistry of A beta (the principal component of amyloid in AD) and of the clinical potential of chelators in AD treatment. My most recent studies have focused on identifying the normal function of A beta. The findings from these studies suggest A beta is a member of the family of essential innate immune effector biomolecules known as antimicrobial peptides.
Moir Lab, Genetics and Aging Research Unit, MIND
MIND Faculty Profile
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