Scott R. Plotkin, MD, PhD - Basic science and clinical research for NF1, NF2, and schwannomatosis.
- Lab phone: 617-724-9584
- Clinic phone: 617-724-7856
Biography
Affiliations
Research Investigator Profile
Scott R. Plotkin, MD, PhD
- Assistant Professor of Neurology,
Harvard Medical School - Assistant Neurologist,
Massachusetts General Hospital - Director, Neurofibromatosis Clinic
- Director, MGH-DFCI-BWH
Neuro-Oncology Fellowship Program
Research Description
Our clinical research group is interested in characterizing the phenotype of patients with tumor suppressor syndromes such as neurofibromatosis (NF). We are performing whole-body MRI scans in patients to measure the distribution and volume of internal nerve sheath tumors in patients with NF1, NF2, and schwannomatosis. We are also using laser scanning techniques to measure the number and height of cutaneous tumors in subjects with NF1. The second clinical research interest is in developing new therapies for patients with NF. Thus, we are designing and executing clinical trials for these diseases using small molecule inhibitors of growth factor pathways. The final interest in our group is to understand the genetic basis for schwannomatosis, the third for of NF. We are studying blood and tumor specimens from these patients to determine the role of the NF2 and INI1 genes in tumor suppression.
Research Lab: Stephen E. and Catherine Pappas Center for Neuro-Oncology
| Research interests |
Neurofibromatosis, schwannomatosis, primary brain tumors, metastatic brain tumor |
| Research techniques | Clinical trials, mutational analysis, advanced imaging techniques (MRI and PET) |
| Diseases studied | Neurofibromatosis, neuro-oncology |
| Selected publications |
|
| NCBI PubMed link | NCBI PubMed Publications |
| E-mail address | splotkin@partners.org |
| Lab mailing address | Massachusetts General Hospital Cancer Center Stephen E. & Catherine Pappas Center for Neuro-Oncology Mailcode: YAW Ste 9E 55 Fruit Street Boston, MA 02114 |
| Clinical interests | Neurofibromatosis, neuro-oncology |
| Clinical address | Pappas Center for Neuro Oncology 55 Fruit Street YAW 9 Boston, MA 02114 |
|
Clinical website address |
Neurofibromatosis Clinic |
Updated 05/17/2011
