Research Investigator Profile

Dr. Jonathan Rosenberg

Jonathan Rosand, MD, MSc

Professor of Neurology,
Harvard Medical School

Chief, Division of Neurocritical Care,
Massachusetts General Hospital


Medical Director, Neuroscience Intensive Care Unit, Massachusetts General Hospital

Faculty Member, Broad Institute of MIT and Harvard

Faculty Member, CHGR 




Research Description

The long-term goal of our research is to develop more effective methods for the prevention and treatment of stroke. Our group uses clinical, neuroimaging and genetic characterization of patients with stroke in order to improve understanding of the risk and clinical course of cerebrovascular disease. In addition to our broad-based genetic studies, we continue to enroll patients with hemorrhagic and ischemic stroke in longitudinal studies of stroke outcome. All of our efforts involve collaborations with other groups, within the Department of Neurology, the Center for Human Genetic Research, the Broad Institute, and the Martinos Center for Biomedical Imaging, as well as within the International Stroke Genetics Consortium.

To learn more, visit Dr. Rosand's research page at the CHGR.

Research interests Ischemic Stroke, Hemorrhagic Stroke, White Matter Disease, Cerebral Amyloid Angiopathy, CADASIL
Research techniques Genome-Wide Association Studies, Fine Mapping, Whole Exome Sequencing, , Gene Expression Analysis, Candidate Gene Studies, Neuroradiological Quantification of White Matter and Stroke Lesion Volumes
Diseases studied Ischemic Stroke, Hemorrhagic Stroke, Intracerebral Hemorrhage, White Matter Disease, Cerebral Amyloid Angiopathy, CAA, CADASIL
Selected publications
  1. Rost NS, Smith EE, Chang Y, Snider RW, Chanderraj R, Schwab K, Fitzmaurice E, Wendell L, Goldstein JN, Greenberg SM, Rosand J.Prediction of functional outcome in patients with primary intracerebral hemorrhage: The FUNC Score. Stroke 2008; 39:2304-2309.
  2. Kumar MA, Rost NS, Snider RW, Chanderraj R, Greenberg SM, Smith EE, Rosand J. Anemia and hematoma volume in acute intracerebral hemorrhage. Critical Care Medicine. 2009;37:1442-47
  3. Biffi A, Anderson CD, Desikan RS, Sabuncu M, Cortellini L, Schmansky N, Salat D, Rosand J. Sequence variation influences neuroimaging measures in Alzheimer’s disease. Archives of Neurology 2010; in press
  4. Anderson CD, Biffi A, Rost NS, Cortellini L, Furie KL, Rosand J. Chromosome 9p21 in ischemic stroke: population structure and meta-analysis. Stroke 2010; in press
  5. The International Stroke Genetics Consortium and the Wellcome Trust Case-Control Consortium 2. Failure to Validate Association between Variants on 12p13 and Ischemic Stroke. New England Journal of Medicine 2010; in press
NCBI PubMed link NCBI PubMed Publications
E-mail address
Lab mailing address Center for Human Genetic Research
185 Cambridge Street
Boston, MA 02114
Clinical interests NeuroCritical Care and Stroke
Clinical address Massachusetts General Hospital
Neurology, Suite 835
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA
Clinical website address Stroke Service
Neuroscience Intensive Care Unit




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