Kevin J. Staley, MD, Research Investigator, Pediatric Epilepsy Research Lab at Mass General Hospital

  • Clinic Phone: 617-724-6400

Research Investigator Profile

Kevin Staley's photo for the MGH Find a Doctor directory

Staley, Kevin Joseph, MD

  • Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation, Harvard Medical School
  • Unit Chief, Pediatric Neurology, Massachusetts General Hospital

 

 

Research Description

Neuronal ion transport and the spread of activity in neural networks are the two major themes in the lab. Neuronal ion transport underlies signaling at all fast synapses. The importance of neuronal ion transport was underscored by our recent discovery that reversed ion transport in the immature brain was blocking the effects of the anticonvulsants most commonly used to treat neonatal seizures, and that a safe and well-characterized diuretic could ameliorate this condition. Visit Dr. Staley's Pediatric Epilepsy Research Lab for more detail.

Research interests Epilepsy, synaptic physiology, neuronal ion transport, neural network activity.
Research techniques Single cell electrophysiology, in vivo radiotelemetry, ion-sensitive fluorescent imaging of ion transport and neural network activity, computer modeling.
Diseases studied Epilepsy
Selected publications
  1. Dyhrfjeld-Johnsen J. Berdichevsky Y, Swiercz W, Sabolek H, Staley KJ.  Interictal spikes precede ictal discharges in an organotypic hippocampal slice culture model of epileptogenesis.  J Clin Neurophysiol in press 2010
  2. Glykys J, Kuchibhotla KV, Feng G, Kuner T, Augustine G, Bacskai BJ, Staley KJ.  Differences in cortical vs. subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures.  Neuron 63:657-72, 2009.
  3. White A, Williams PA, Hellier J, Clark S, Dudek FE and Staley KJ. EEG spike activity precedes epilepsy after kainate-induce status epilepticus. Epilepsia in press 2009
  4. Brumback A and Staley KJ, Thermodynamic regulation of NKCC1-mediated Cl- cotransport underlies plasticity of GABAA signaling in neonatal neurons, J Neurosci 28:1301-12, 2008
  5. Dzhala V Brumback A and Staley KJ. Bumetanide enhances phenobarbital efficacy in a neonatal seizure model.   Ann Neurol 63:222-235, 2008
NCBI PubMed link NCBI PubMed Publications
E-mail address

staley.kevin@mgh.harvard.edu

 

Lab mailing address

Kevin J. Staley, MD
Massachusetts General Hospital
114 16th Street
Charlestown, MA 02129

Lab website Pediatric Epilepsy Research Lab
Clinical interests Epilepsy, Neonatal seizures
Clinical address Massachusetts General Hospital
Neurology, Suite 835
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA

Clinical website address

Pediatric Epilepsy Service