Dr. Wasco's laboratory is interested in factors and events that surround the neuronal degeneration that is characteristic of Alzheimer's disease and normal aging.

  • Lab Phone: 617-726-8307

Research Investigator Profile

Wilma Wasco

Wilma Wasco, PhD

  • Associate Professor,
    Harvard Medical School

 

 

 

 

 

Research Description

Dr. Wasco's laboratory is interested in factors and events that surround the neuronal degeneration that is characteristic of Alzheimer's disease and normal aging. The laboratory studies the regulation and function of genes that have been associated with Alzheimer's disease.

Dr. Wasco's lab has been directly involved in the identification and characterization of a number of such genes - two amyloid precursor-like proteins (APLP1 and APLP2), both of the presenilin proteins (PS1 and PS2) and calsenilin, a presenilin interacting protein that is also a neuronal calcium binding protein. By understanding the biological role that each protein plays in both the normal and the aging brain and determining how disease associated mutations change these functions, we can begin to understand neuronal degeneration and explore rational therapeutic interventions.

Research interests Genetics
Research techniques
Diseases studied Alzheimer's disease
Selected publications

Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.

Myre MA, Washicosky K, Moir RD, Tesco G, Tanzi RE, Wasco W.

Cell Signal. 2009 Apr;21(4):567-76. Epub 2008 Dec 25.PMID: 19154786
NCBI PubMed link NCBI PubMed Publications
E-mail address
wasco@helix.mgh.harvard.edu
Lab mailing address
MassGeneral Institute for Neurodegenerative Disease
Building 114, Room 3000
114 16th Street
Charlestown, MA 02129