Anne B. Young, MD, PhD
- Lab Phone: 617-726-1262
Research Investigator Profile
Affiliations
- Professor of Neurology,
Harvard Medical School - Founder and Scientific Director,
MassGeneral Institute for Neurodegenerative Disease
Anne B. Young, MD, PhD
Research Description
Dr. Young’s laboratory is examining the role of the protein alpha-synuclein, which plays a key role in the death of dopamine-producing brain cells in the Parkinson’s disease and other diseases with similar symptoms. Recently Dr. Young’s laboratory has examined the biology of synuclein in a group of Parkinson-like disorders, the Multiple Systems Atrophies. These studies suggest novel mechanisms in synuclein turnover, which may be relevant for treatments targeted at this protein.
In addition to her work in Parkinson’s disease, Dr. Young’s laboratory is attempting to elucidate cellular and systems mechanisms underlying the pathophysiology of Huntington’s disease. In an effort to help develop therapeutic targets for human movement disorders, she is conducting studies on the vulnerability of neurons to excitotoxic injury and the selective expression of glutamate receptors in these neurons.
| Research interests | Alpha-synuclein, genetics, expression of glutamate receptors |
| Research techniques | Laser capture micro dissection, gene mircro arrays, protein chemistry |
| Diseases studied | Huntington's and Parkinson's diseases |
| Selected publications |
|
| NCBI PubMed link | NCBI PubMed Publications |
| NIH biosketch |
Anne B. Young, MD, PhD (PDF) |
| Lab mailing address |
MassGeneral Institute for Neurodegenerative Disease |
| Lab, institute or center websites | MassGeneral Institute for Neurodegenerative Disease |
