Massachusetts General Hospital (MGH) investigators have determined that one of the recently identified genes contributing to the risk of late-onset Alzheimer's disease regulates the clearance of the toxic amyloid beta (A-beta) protein that accumulates in the brains of patients with the disease. In their report receiving advance online publication in Neuron, the researchers describe a protective variant of the CD33 gene that promotes clearance of A-beta from the brain. They also show that reducing expression of CD33 in immune cells called microglia enhances their ability to clear away A-beta protein, raising the possibility that blocking CD33 activity could help the brain’s immune system remove A-beta. Read more.
Services for the Media
5/22/2013: Survey points out deficiencies in addictions training for medical residents A 2012 survey of internal medicine residents at Massachusetts General Hospital found that more than half rated the training they had received in addiction and other substance use disorders as fair or poor. In response to the findings the MGH has increased residents' training in addiction medicine.
5/20/13: Genetic diversity within tumors predicts outcome in head and neck cancer A new measure of the heterogeneity – the variety of genetic mutations – of cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer.
5/15/13: Study finds disagreement on the role of primary care nurse practitioners A New England Journal of Medicine study finds that, while primary care physicians and nurse practitioners agree that nurse practitioners "should be able to practice to the full extent of their education and training," they significantly disagree about some proposed changes to the scope of nurse practitioners' responsibilities.
5/14/13: Treatment with two osteoporosis drugs better at increasing bone density than single-drug therapy A combination of two FDA-approved osteoporosis drugs with different mechanisms of action was found to increase bone density better than treatment with either drug alone in a small clinical trial.
5/13/13: Massachusetts General Hospital Receives Highest Nursing Credential With Prestigious Magnet® Recognition … Again The Massachusetts General Hospital has again attained Magnet® recognition as part of the American Nurses Credentialing Center’s Magnet Recognition Program®. This voluntary credentialing program recognizes excellence in nursing and is the highest honor an organization can receive for professional nursing practice.
Newsletters & Publications
Hotline Each week, MGH Hotline reports important news within the Massachusetts General Hospital community featuring employees and initiatives that focus on bettering the future of clinical care, research and training.
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05/23/2013: A Risky Habit We Shouldn’t Encourage
Room for Debate/New York Times Online
opinion piece by MGH physician Eden Evins
05/23/2013: Disability and Discrimination at the Doctor’s Office
Well/New York Times Online
quotes MGH investigator Lisa Iezzoni
05/23/2013: What Lies Beneath: Heart Health & Triathlon
feature on cardiovascular performance performance evaluation for athletes conducted by MGH physician Aaron Baggish
05/23/2013: Labs reject dramatic findings on cancer drug in Alzheimer's mice
coverage of report from group including MGH investigator Rudolph Tanzi
05/23/2013: Alzheimer's drug was too good to be true, studies find
Vitals/NBC News Online
05/23/2013: Sparking Innovation: Patients First, Mice Second
article by and video featuring MGH physician Robert Gerszten discussing new MGH Institute for Heart, Vascular and Stroke Care