Massachusetts General Hospital (MGH) investigators have determined that one of the recently identified genes contributing to the risk of late-onset Alzheimer's disease regulates the clearance of the toxic amyloid beta (A-beta) protein that accumulates in the brains of patients with the disease. In their report receiving advance online publication in Neuron, the researchers describe a protective variant of the CD33 gene that promotes clearance of A-beta from the brain. They also show that reducing expression of CD33 in immune cells called microglia enhances their ability to clear away A-beta protein, raising the possibility that blocking CD33 activity could help the brain’s immune system remove A-beta. Read more.
Services for the Media
5/20/13: Genetic diversity within tumors predicts outcome in head and neck cancer A new measure of the heterogeneity – the variety of genetic mutations – of cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer.
5/15/13: Study finds disagreement on the role of primary care nurse practitioners A New England Journal of Medicine study finds that, while primary care physicians and nurse practitioners agree that nurse practitioners "should be able to practice to the full extent of their education and training," they significantly disagree about some proposed changes to the scope of nurse practitioners' responsibilities.
5/14/13: Treatment with two osteoporosis drugs better at increasing bone density than single-drug therapy A combination of two FDA-approved osteoporosis drugs with different mechanisms of action was found to increase bone density better than treatment with either drug alone in a small clinical trial.
5/13/13: Massachusetts General Hospital Receives Highest Nursing Credential With Prestigious Magnet® Recognition … Again The Massachusetts General Hospital has again attained Magnet® recognition as part of the American Nurses Credentialing Center’s Magnet Recognition Program®. This voluntary credentialing program recognizes excellence in nursing and is the highest honor an organization can receive for professional nursing practice.
5/08/13: Mass. General, Duke study identifies two genes that combine to cause rare syndrome Researchers from MGH and Duke University have identified genetic mutations that appear to underlie a rare but devastating syndrome combining reproductive failure with cerebellar ataxia – a lack of muscle coordination – and dementia.
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05/17/2013: Boston bombing survivor’s fiancée: ‘I knew he’d fight’
Rock Center/NBC News
video report featuring MGH patient Marc Fucarile
05/17/2013: Patriots tight end Rob Gronkowski to have fourth surgery
coverage mentioning MGH physician Jesse Jupiter
05/17/2013: Rob Gronkowski surgery ‘likely’ next week
05/16/2013: Google CEO Larry Page writes a big check to Boston's Voice Health Institute
Boston Business Journal
coverage of gift to program led by MGH physician Steven Zeitels
05/16/2013: Combining Bone-Building Drugs Key to Making Bones Stronger
Healthland/Time Magazine Online
coverage of study led by MGH physician Ben Leder