In this week's edition: "200 years at the research frontier," "Warren Triennial Prize honors visionary research," "How - and when - to make a protein," "Gaining ground in limb replacement surgery," and more.

Stories in the 10/28/2011 Issue of Hotline

200 years at the research frontier

The awarding of the 2011 Warren Triennial Prize — established in 1871 to honor MGH co-founder John Collins Warren, MD – seems an appropriate time to celebrate the MGH research program, which stands today as the largest hospital-based research program in the United States.

Defining and diagnosing appendicitis

MGH pathologist Reginald Heber Fitz, MD, first described appendicitis – a term he coined – and suggested a “radical operation” to remove the inflamed structure in an 1886 presentation to the first meeting of the Association of American Physicians.

From the Tumor Clinic to the Termeer Center

The MGH Tumor Clinic – the first clinic of its kind at a general hospital – was established in 1925 and led by George W. Holmes, MD, chief of the X-ray Department, who brought together staff from various disciplines to discuss cancer cases in which radiation had proved effective when the traditional treatment of surgery had failed.

Gaining ground in limb replacement surgery

The first successful replantation of a human limb took place at the MGH in 1962. Now, nearly 50 years later, the Division of Plastic and Reconstructive Surgery is in the process of reviewing potential candidates for the latest in medical advances – hand transplantation surgery.

How – and when – to make a protein

Paul C. Zamecnik, MD, was associated with the MGH for more than 50 years. During that time, he made several fundamental discoveries related to how and when the genetic code carried in DNA is translated into protein molecules.

Outcomes research: Embracing Ernest

In a 1915 cartoon commissioned by Ernest Amory Codman, MD, an ostrich with its head stuck in the sand satirized his view of the MGH approach to quality and safety.

Warren Triennial Prize honors visionary research

Members of the MGH research community filled beyond capacity both the third-floor auditorium in the Simches Research Center and a nearby conference room for the Oct. 25 celebration of the 2011 Warren Triennial Prize.

What's Happening

What's Happening items for Oct. 28


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