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Inhibition of nociceptors using capsaicin and the lidocaine derivative, QX-314

Click this link to read the Nature paper by Binshtok, Bean and Woolf (2007) describing sensory specific blockade.

Watch Professor Woolf on NECN describing the study.

Watch Professor Bean and Alex Binshtok on NBC nightly news (click "watch the video" at the top of the linked page).

Listen to a Nature podcast of Clifford Woolf and Bruce Bean talking about the study and its implications in a clinical setting.

The role of BH4 in pain development

Click this link to read the Nature Medicine paper by Tegeder et al., (2006) describing GTP cyclohydrolase and tetrahydrobiopterin and their regulation in pain sensitivity and persistence.

Commentary on BH4 and GCH1 in Nature Medicine News and Views.

Review featured in Science, 27th October 2006.

Review featured in Lancet Neurology, December 2006.

Image illustrating the relationship between BH4, GCH1 and nociception.