Research

Some of the major research interests of the group include:

• The role of the DRAGON/RGM family of membrane associated proteins.
• Role of tetrahydrobiopterin in pain.
• Neuro-immune interactions.
• Post-translational processing and transcriptional control of membrane receptors and ion channels mediating pain hypersensitivity.
• Intracellular signal transduction cascade and transcription factor activation in neurons.
• Mechanisms responsible for cell survival in injured sensory and motor neurons,
• Relative contributions of intrinsic growth determinants and extrinsic growth inhibitors in establishing regenerative capacity in the central nervous system.
• Role of cell death in producing neuropathic pain.
• Central sensitization. It's mechanism and contribution to pain
• Clinical trials to establish the mechanisms responsible for producing pain.

Recent features on the research activities of the group

Genetic variations explain why everyone experiences pain differently, Protomag (5/22/07)

Common genetic variant dampens pain, Harvard Focus (10/27/2006)

The role of BH4 in pain sensitivity, Harvard Gazette (11/16/2006)

The Science of hurt, Harvard Magazine (12/1/2005)

Protector Protein Part of Nerve Cell Defense, Harvard Focus (10/11/2002)

Chili peppers and inflammation: Harvard Focus (9/25/2002)

Touch sensation, Harvard Focus (4/20/2001)

Central mechanisms of pain role of Cox-2, Harvard Focus (4/6/2001)

Pain and memory, Harvard Gazette (2/3/2000)

Findings Suggest New Approaches To Easing Chronic Pain, Harvard Focus (1/8/1999)

 

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