reproductive medicine

Reproductive Medicine Program

The Reproductive Medicine Program at the Massachusetts General Hospital Department of Obstetrics and Gynecology provides sophisticated, compassionate care for reproductive health problems, placing the highest emphasis possible on patient safety.


We firmly believe in continuity of care, both within our division and in each patient's relationship with her primary obstetrician/gynecologist. Our work focuses on not just treating the patient successfully but also returning her to her community physician's care as soon as possible.

Patients can receive services in several locations: on the main campus of Massachusetts General Hospital  in Boston as well as at the Mass General/North Shore Center for Outpatient Care in Danvers. (Please note: We will continue to offer egg retrievals and embryo transfers only at our main campus.)

What to Expect

Our patients are assigned a clinical team that includes a physician, medical assistant, nurse, insurance advocate and administrative assistant. This team approach helps us to offer close, personal attention and maintain a supportive atmosphere.

Prior to your first visit, you'll either receive a questionnaire to fill out or a call from a nurse who will obtain your medical history. In addition, you'll likely receive a call from your insurance advocate to go over financial issues. We want to make sure you're aware of all possible out-of-pocket costs before you start treatment.

At your initial consultation, your assigned nurse will review your questionnaire with you. Next, your physician will meet with you to discuss your goals and concerns before completing any necessary evaluations. Some patients leave the appointment with their personalized treatment plan. Others must first undergo further testing.

Throughout your experience here, we will treat you like a friend rather than a number, greet you by your first name, listen to your concerns, educate you, understand when things are not going as planned and be your biggest fan when things are going well.

Safety: Our Primary Concern

The Mass General Fertility Center has enjoyed great success in helping women become pregnant. For details on in vitro fertilization (IVF) and other assisted reproductive technologies (ART) rates, please visit the Society for Assisted Reproductive Technology or the Centers for Disease Control and Prevention.

We never aim for success at the expense of patient safety. As part of a world-class academic medical institution, we adhere to the most demanding safety standards. In fact, our division must pass the same safety inspections administered by the Joint Commission (JCAHO) as Mass General does as a whole.

How else does our commitment to safety shine through?

  • Mass General was among Boston's first hospitals to offer single-embryo transfer, greatly reducing the rate of multiple births with IVF
  • Our division regularly conducts simulations that enhance our ability to handle any emergency procedure that may arise. Also, our location within the Mass General campus gives patients the reassurance of being close to the highest quality medical care should the need arise
  • John Petrozza, MD and Mary Sabatini, MD, PhD have extensive experience in minimally invasive reproductive and gynecologic surgery and are certified in the fundamentals of laparoscopic surgery
  • We have used an electronic medical record (EMR) system since 2003 to facilitate our access to patient information and help improve safety

About this Program

Our program treats the full range of problems related to reproductive health. We welcome single women, male/female couples, same-sex couples and all couples where natural conception may not be possible.

Our program offers nonsurgical treatments such as:

  • Single-embryo transfer; egg, sperm and embryo cryopreservation; and other assisted reproductive technologies (ART)
  • Third-party reproduction (e.g. sperm donation, egg donation and gestational surrogacy)
  • Preimplantation genetic diagnosis, a procedure that screens for serious and life-threatening genetic diseases
  • Ultrasound and early prenatal diagnostic care
  • Management of pelvic pain 
  • Evaluation and treatment for recurrent pregnancy loss
  • Fertility-preservation counseling prior to chemotherapy

Patients can receive all nonsurgical treatments, as well as in vitro fertilization (IVF), within our self-contained unit in the Yawkey Building for Outpatient Care. We also perform some procedures (e.g. polypectomies) in the office with local anesthesia rather than the operating room.

Leaders in Minimally Invasive Surgery

Working closely with the Massachusetts General Hospital Center for the Integration of Medicine and Innovative Technology in the Operating Room of the Future, we employ advanced minimally invasive techniques when possible to enhance the patient experience. Common examples include:

  • Laparoscopy for endometriosis or pelvic adhesions (scar tissue)
  • Various procedures to remove uterine cysts or fibroids
  • Laparoscopic tubal reanastomosis to reverse tubal ligations
  • Robot-assisted laparoscopy to remove fibroids
  • Procedures specifically for treating pelvic pain (e.g. presacral neurectomy and uterine suspension)
  • Hysteroscopy to remove fibroids, polyps or adhesions

Additional Services

Patients may also benefit from services such as:

  • Counseling to work through concerns about fertility, third-party reproduction options, marital discord, etc.
  • Management of psychological medications by an affiliated neuropharmacologist or psychopharmacologist
  • Mind-body therapy available in collaboration with the Benson-Henry Institute for Mind Body Medicine and local acupuncturists
  • Weight management guidance via the Weight Center
  • Genetic counseling via the Genetics Center

A Group Practice

John Petrozza, MD, chief of the Mass General Fertility Center, is board-certified in reproductive medicine and infertility as well obstetrics and gynecology. In addition to Dr. Petrozza, our team includes an impressive group of professionals with specialized expertise in treating a variety of conditions.

Our single-faculty practice also comprises academic physicians and embryologists who have a wide range of clinical and research interests. This diversity of perspectives—along with the synergy that comes with our team approach—means we can offer patients a number of treatment options in addition to IVF.

Conditions & Diseases

The links below provide more information about conditions and diseases that could be treated within this program.

  • Amenorrhea

    Amenorrhea is a menstrual condition characterized by absent menstrual periods for more than three monthly menstrual cycles.

  • Chronic Pain

    Chronic pain is long-standing pain that persists beyond the usual recovery period or occurs along with a chronic health condition, such as arthritis.

  • Endometriosis

    Endometriosis is a common gynecological condition involving abnormal buildup of tissue, often causing pain or infertility.

  • Fibrocystic Breast Changes

    Generalized breast lumpiness is known by names such as "fibrocystic disease" and "fibroid breasts." Doctors now believe these are just part of the normal breast changes many women undergo throughout the various stages of their lives.

  • Hypothyroidism and Pregnancy

    Hypothyroidism is a condition marked by an underactive thyroid gland and may occur during pregnancy

  • Infertility

    Infertility is defined by the American Society for Reproductive Medicine (ASRM) as a disease of the reproductive system that impairs the body's ability to perform the basic function of reproduction.

  • Osteoporosis

    Osteoporosis, or porous bone, is a disease in which there is a loss of bone mass and destruction of bone tissue, causing weakening of the bones in the hips, spine and wrists.

  • Pelvic Inflammatory Disease (PID)

    Caused by a certain type of bacteria, pelvic inflammatory disease results in pelvic pain and the possibility of an ectopic pregnancy (a fertilized egg becoming implanted outside the uterus).

  • Pelvic Pain

    Pelvic pain may originate in genital or extragenital organs in and around the pelvis, or it may be psychological, which can make pain feel worse or actually cause a sensation of pain, when no physical problem is present.

  • Perimenopause

    Perimenopause refers to the transitional period of time before menstruation actually stops, which is marked by changes in the menstrual cycle, along with other physical and emotional symptoms.

  • Polycystic Ovarian Syndrome (PCOS)

    Polycystic ovarian syndrome involves two of the following: lack of ovulation for an extended period of time, high levels of male hormones or small ovarian cysts.

  • Postpartum Thyroiditis

    One particular postpartum complication is postpartum thyroiditis, a condition characterized by an inflamed thyroid gland.

  • Pregnancy

    A pregnancy is divided into three phases, called trimesters. Each trimester has its own significant milestones.

  • Premenstrual Dysphoric Disorder (PMDD)

    A much more severe form of the collective symptoms known as premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD) is a chronic medical condition that requires attention and treatment.

  • Premenstrual Syndrome (PMS)

    Most women experience some unpleasant or uncomfortable symptoms during their menstrual cycle.

  • Symptoms and Diagnosis of Multiple Pregnancy

    Symptoms of multiple pregnancy may include: uterus is larger than expected for the dates in pregnancy, increased morning sickness, increased appetite, excessive weight gain - especially in early pregnancy, or fetal movements felt in different parts of abdomen at same time.

  • Uterine Fibroids

    Fibroids are the most frequently seen tumors of the female reproductive system.

Clinical Trials


Reproductive Medicine Program

Yawkey Center for Outpatient Care
55 Fruit Street
Suite 10A
Boston, MA 02114
Phone: 617-726-8868
Fax: 617-724-8882

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