Oral and Maxillofacial Surgery Research

Research in the Department of Oral and Maxillofacial Surgery ranges from tissue engineering to development of new surgical techniques and improving clinical outcomes.

Research Labs

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  • Skeletal Biology Research Center

    The Skeletal Biology Research Center (SBRC) applies advances in treatment to the art of reconstruction for congenital and acquired facial deformities.

Research Projects

Hallissa Gomes Pereria
Evaluating the effects of marijuana on orthodontic tooth movement in rats
The study intends to understand better the effect of Cannabis sativa on bone remodeling, the rate of orthodontic space closure using an intraoral appliance, and determine if root resorption is affected by exposure to Cannabis sativa in rats. For this we will use rats, cone-beam computed tomography (CBCT), orthodontic appliances, digital slide calipers, Dynamometer and histology analysis.

Jose Pereira Da Silva
Associated Osteonecrosis of the Jaws (MRONJ)
The aim of this study is to identify possible gene polymorphism that could trigger the onset of MRONJ and this will provide information on the feasibility and clinical applicability of genome sequencing in MRONJ. The study population will be divided in three groups. Blood samples of all three groups will be collected for genomic DNA extraction.  The control group will be consisted of healthy patients who will be submitted to orthognathic surgery. Blood samples will be collected before the surgical procedure with patients under general anesthesia. Blood samples from a database of patients diagnosed with multiple myeloma will be selected from Center for Multiple Myeloma, Massachusetts General Hospital Cancer Center , treated with IV Zoledronic acid. Data collection will include demographics, clinical data of underlying disease and drug intake of patients who has presented (group II) or not clinical diagnosis of ONJ (group III).

Joshua Christopher Kwolek
Vidscrip Study
A randomized controlled trial on the effects of audiovisual media on patient retention of care information in an outpatient setting. Goal is to produce a 35% increase in retention. This should be starting soon.

Radiography Study
A retrospective analysis as part of ongoing quality efforts within the department. Examining repeats of panoramic, PA cephalometric, and Lateral cephalometric radiographs and comparing these to international baselines.

Quality and Safety Review
Aims to provide historical context for and overview of the modern American healthcare Quality and Safety landscape. Terminology, acronyms, organizations, and interconnections are examined and summarized in the context of the medical industry and American health policy as a whole.

Baboucarr Lowe
Mandible reconstruction in minipig
This project is focused on combined application of 3D printed scaffolds and autologous stem cells for reconstruction of large biocortical defects on Yucatan minipig Models. Also, working on developing an alternative fabrication strategy for in house printing of 3D scaffold for bone tissue engineering applications with improved micro-architecture.

Temporomandibular regeneration
This project is aimed at fabricating a highly functionalized nano-gel for temporomandibular (TMJ) regeneration on mouse model. As part of this project, we will study the joint anatomy (TMJ and Knee) and develop a protocol for arthroscopic partial discectomy on mice (both TMJ and knee joints).

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