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Giant Cell Tumors of the Jaw

Mass General has an innovative treatment program for this benign yet aggressive tumor that is less radical and experiences better outcomes than traditional radical treatments.

Although benign, giant cell tumors of the jaw can be aggressive, locally destructive, and disfiguring. Traditionally, patients with giant cell tumors faced resection of the jaw, including removal of surrounding bone and nerves, followed by reconstructive surgery.

The Department of Oral and Maxillofacial Surgery, through its Skeletal Biology Research Center, has developed an alternate treatment for patients with these tumors that involves a single, less radical procedure followed by chemotherapy. First reported in the journal Pediatrics in 1999, our group has had remarkable success treating giant cell tumors with less invasive enucleation of the tumor followed by postoperative antiangiogenic therapy using interferon. This is in contrast to surgical removal of the area and reconstruction with a bone graft. With an enrollment of over 40 subjects in this protocol, the recurrence rate is 5% compared to an historic recurrence rate of 30-60% for these tumors. When the tumor recurs, it can be retreated with interferon or a combination of interferon and a bisphosphonate. For more information, visit the SBRC website.

We continue to enroll patients to study the long-term outcomes of those treated and to identify other variables that can improve treatment of patients with these and similar conditions.  For patient or physician inquiries about this novel protocol or enrolling in our study, contact us at (617) 726-2740.

Giant Cell Tumor

A giant cell tumor is one that is made up of a large number of benign (non-cancerous) cells that form an aggressive tumor - usually near the end of the bone near a joint.

The following related clinical trials and research studies are currently seeking participants at Massachusetts General Hospital. Search for clinical trials and studies in another area of interest.

Department of Oral and Maxillofacial Surgery

Warren Building
55 Fruit Street
Suite 1201
Boston, MA 02114

Phone: 617-726-8222
Fax: 617-726-2814

Public Transportation Access: yes
Disabled Access: yes

Patient Appointments:  (617) 726-2740

OMS Care Center is located in the Wang ACC Building, Suite 201