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The Biomaterials Laboratory located on Jackson 11 is under the direction of Dr. Arun Shanbhag. The laboratory continues to lead the way in identifying novel opportunities to help the orthopaedic patients. Capitalizing on advances in genomics, the laboratory is working in collaboration with deCODE genetics - an Iceland based population-genomics company, to identify the Genetic Markers for Osteoarthritis. Our arthroplasty surgeons Drs. Dennis Burke, Andrew Freiberg, Murali Jasty, Harry E. Rubash and William Tomford have been recruiting patients for this important study.
In other studies, we are using cDNA microarrays to investigate the gene
expression profile of macrophage interactions with biomaterials. We are also
working to identify the mechanisms by which bisphosphonates stimulate osteoblastic
differentiation and maturation. These studies include in-vitro studies using
bone marrow cells and an in-vivo rabbit model.
This Laboratory will continue to provide unique opportunities for scientists, residents, fellows and staff and is an integral part of the future of Orthopaedic Research at MGH.
