Physician Photo

Francis John Hornicek, Jr., MD, PhD

Chief, Orthopaedic Oncology Service

Co-Director, Center for Sarcoma and Connective Tissue Oncology

Professor of Orthopedic Surgery, Harvard Medical School

Dr. Hornicek is an accomplished surgeon and researcher who specializes in treating patients with bone and soft tissue tumors.

Department of Orthopaedics


  • Cancer Center
  • Osteosarcoma (Bone Cancer)
  • Sarcoma and Connective Tissue Oncology
  • Chordoma
  • Multiple Myeloma
Clinical Interests
Benign bone and soft tissue tumors
Malignant bone and soft tissue tumors
Metastatic bone disease
Bone infections
Metabolic bone disease
Boston: Massachusetts General Hospital
Danvers: The Mass General/North Shore Center for Outpatient Care
Medical Education
PhD, Georgetown University School of Medicine
MD, University of Pittsburgh School of Medicine
Residency, Jackson Memorial Hospital
Board Certifications
Orthopaedic Surgery, American Board of Surgery
Patient Age Group
Adult and pediatric
Accepting New Patients
Accepting New Patients


Dr. Francis Hornicek graduated with a BA in biology and mathematics from Washington and Jefferson College. He earned his PhD in physics-biophysics from Georgetown University and his MD from the University of Pittsburgh. Dr. Hornicek completed his Orthopaedic Surgical Residency at the University of Miami and an Orthopaedic Oncology Fellowship at Massachusetts General Hospital and Children's Hospital Boston.

Dr. Hornicek serves as the:

He is an active educator of medical students, residents and fellows, and he is involved in important cancer research.


Dr. Hornicek's clinical research interests include heterotopic ossification, allograft transplantation, immunotherapy, and outcome research for musculoskeletal tumors.

Dr. Hornicek's basic research efforts have focused on specific aspects of cell biology and more recently, molecular biology of sarcomas. Dr. Hornicek has also focused on the development of new chemotherapeutic drugs isolated from marine organisms for the treatment of sarcomas. This has led to clinical trials and patent applications. Dr. Hornicek plans to continue research efforts in the basic and clinical sciences and maintain integration with his clinical practice of orthopaedic oncology and tissue banking.


Select Publications:

Yoon SS, Duda DG, Karl DL, Kim TM, Kambadakone AR, Chen YL, Rothrock C, Rosenberg AE, Nielsen GP, Kirsch DG, Choy E, Harmon DC, Hornicek FJ, Dreyfuss J, Ancukiewicz M, Sahani DV, Park PJ, Jain RK, Delaney TF. Phase II Study of Neoadjuvant Bevacizumab and Radiotherapy for Resectable Soft Tissue Sarcomas. Int J Radiat Oncol Biol Phys. 2010 Oct 5.

Susa M, Choy E, Liu X, Schwab JH, Hornicek FJ, Mankin H, Duan Z. Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. Mol Cancer Ther. 2010 Sep 29.

Devisetty K, Kobayashi W, Suit HD, Goldberg SI, Niemierko A, Chen YL, Raskin KA, Schwab JH, Springfield DS, Yoon SS, Hornicek FJ, Delaney TF. Low-Dose Neoadjuvant External Beam Radiation Therapy for Soft Tissue Sarcoma. Int J Radiat Oncol Biol Phys. 2010 Sep 21.

Tejwani A, Kobayashi W, Chen YL, Rosenberg AE, Yoon S, Raskin KA, Rosenthal DI, Nielsen GP, Hornicek FJ, Delaney TF. Management of acral myxoinflammatory fibroblastic sarcoma. Cancer. 2010 Aug 24.

Guo Y, Nemeth JA, O'Brien C, Susa M, Liu X, Zhang Z, Choy E, Mankin H, Hornicek FJ, Duan Z. Effects of Siltuximab on the IL-6 Induced Signaling Pathway in Ovarian Cancer. Clin Cancer Res. 2010 Aug 10.

Orthopaedic Oncology

Meet the members of our Orthopaedic Oncology team

A special bond

MGH Hotline 08.06.10 This summer, one MGH physician traded his white coat for a suit jacket and his stethoscope for a wedding ceremony script when he officiated the wedding of one of his longtime patients.

Mass General Hospital Physicians make “The List”

Boston Magazine recognizes 134 MGH physicians on its annual list of top doctors in the Boston area.

4th Annual Sacral Tumor Study Group Conference

The 4th Annual Sacral Tumor Study Group Conference, a collaboration with Massachusetts General Hospital, the Mayo Clinic and the Memorial Sloan-Kettering Cancer Center, took place on January 19, 2013.

Hornicek named first Mankin Endowed Scholar

Henry Mankin, MD, an honorary staff member and former chief of the MGH Department of Orthopædics, was recently recognized with a professorship named in his honor: the Henry J. Mankin, MD, Endowed Scholar in Orthopædics.

Four New Professors of Harvard Medical School in Orthopaedic Surgery

Harvard Medical School promoted Francis J. Hornicek, MD, PhD, Orhun K. Muratoglu, PhD, David C. Ring, MD, PhD & Mark S. Vrahas, MD to professors of Orthopaedic Surgery.

Orthopaedic Associates
55 Fruit Street
Yawkey Center for Outpatient Care, Suite 3B
Boston, MA 02114-2696

Phone: 617-724-6802
Fax: 617-726-6823

Mass General/North Shore Center for Outpatient Care
104 Endicott Street
Danvers, MA 01923-3623

Phone: 978-882-6060
Fax: 978-882-6070